The following article is part of coverage from the American Academy of Neurology’s Annual Meeting (AAN 2020). Due to the global COVID-19 pandemic, the Academy made the necessary decision to cancel the meeting originally scheduled for April 25–May 1, 2020, in Toronto. While live events will not proceed as planned, readers can click here catch up on the latest research intended to be presented at the meeting.


Youth with a history of status migrainosus are more likely to experience an increase of >4 headache days per month during a follow-up evaluation, according to results of a study intended to be presented at the annual meeting of the American Academy of Neurology (AAN 2020).

Data on the clinical characteristics of children and adolescents with status migrainosus are sparse and little is known about the prognosis of this patient population. To address this gap, researchers evaluated the clinical features and prognosis of children, adolescents and young adults with a history of status migrainosis using data collected from patients at the Cincinnati Children’s Hospital Headache Center.

Youth with a migraine diagnosis and available data for a follow-up interval of 1 to 3 months were included in the analysis (n=5316). Using information from initial visits, researchers extracted data related to age, sex, race, body mass index, migraine diagnosis, headache frequency, headache severity, disability, allodynia, and lifestyle habits; follow up visits also focused on reason for visit and headache frequency and type.

A total of 559 (10.5%) of the study cohort were found to have a history of status migrainosus. Using a multivariate logistic regression model, investigators found predictors that were significantly associated with status migrainosus included: older age, female sex, white race, as well as a history of migraine with aura, medication overuse headache, higher headache severity, increased disability, and of months with headache at initial consultation.

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Investigators noted that youth with a history of status migrainosus, compared with those without such history, were more likely to experience an increase of >4 headache days per month at follow-up (15.2% vs 11.1%, respectively; c2 [1, n=5,316] = 8.172; P =.0043).

“Youth with status migrainosus represent a distinct subgroup of the migraine population and have an unfavorable short-term prognosis,” concluded the researchers.

Reference

Orr S, Turner A, Kabbouche M, et al. The Profile and Prognosis of Youth with Status Migrainosus: Results From an Observational Study. Intended to be presented at the 2020 annual meeting of the American Academy of Neurology.

Visit Neurology Advisor‘s conference section for complete AAN 2020 coverage.