The following article is part of conference coverage from the American Academy of Neurology (AAN) 2021 Virtual Annual Meeting. Neurology Advisor’s staff will be reporting breaking news associated with research conducted by leading experts in neurology. Check back for the latest news from the AAN 2021 Virtual Annual Meeting.

Remote electrical neuromodulation (REN) is a safe and effective treatment option for the acute treatment of migraine in adolescents, according to study results presented at the American Academy of Neurology (AAN) 2021 Virtual Annual Meeting, held from April 17 to 22, 2021.

Conditioned pain modulation is an endogenous analgesic mechanism that can be induced by REN, a US Food and Drug Administration-cleared acute treatment for migraine in adults. The objective of the current study was to determine the safety and efficacy of REN in adolescents with migraine.

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This open-label, multicenter study included 60 adolescents with migraine between the ages of 12 and 17 years. All participants underwent a 4-week run-in phase during which headaches were recorded. Eligible participants continued to an 8-week treatment phase.

A total of 39 patients completed a test treatment with REN; study researchers recorded their pain severity levels and associated symptoms at treatment initiation, 2 post-treatment, and 24 hours post-treatment.

At 2 hours post-treatment, they recorded pain relief in 28 of 39 (71%) patients, and pain freedom was achieved in 14 of 39 (35%) patients. In more than 40% of patients, nausea, photophobia, and phonophobia disappeared. Functional ability improved in 69% of patients.

Consistency analyses across multiple attacks showed that two-thirds of patients experienced pain relief in 50% or more of their treated attacks, and a third experienced pain-free responses.

Treatment with REN was safe. Of 45 patients who used the device at least once, a single (2%) device-related adverse event of temporary arm pain was reported.

“REN provides clinically meaningful relief of migraine pain and associated symptoms, offering a safe and effective [nonpharmacological] alternative for acute treatment in adolescents,” concluded the study researchers.


Hershey A, Lin T, Gruper Y, Berenson F. Remote electrical neuromodulation for the acute treatment of migraine in adolescents. Presented at: the American Academy of Neurology 2021 Virtual Annual Meeting; April 17 to 22, 2021. Abstract P10.028.