Simultaneous fMRI, Direct Electrical Stimulation Feasible in Epilepsy

Researchers reported that they could easily produce robust fMRI maps of activation networks. These maps indicated a significant positive association between quantitative measures of blood-oxygen-level dependent (BOLD) activity and measures of DES-caused electrical connectivity (mean correlation coefficient, 0.38).

In addition, the successful surgical outcome was consistent with the resection/laser ablation of brain areas that contained high local fMRI activity in 14 patients, which corresponded anatomically with the previous SEEG localization hypotheses, according to the researchers.

Compared with pre-ablation images, 3 patients who received laser ablations of ictal onsets followed by fMRI-DES images demonstrated an elimination of the BOLD signals.

There were no reported complications or adverse events.

“We conclude that laser ablation technology can be applied to medically intractable epilepsy originating from extra temporal regions and without a clear lesion on the MRI,” Dr. Gonzalez-Martinez said.

In the abstract, Gonzalez-Martinez and colleagues wrote that these results suggest that fMRI-DES could be used for full-brain volume evaluation of brain connectivity and help lead to the refinement of laser ablative and other neuro-modulation procedures for epilepsy.

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  1. Gonzalez-Martinez J, Jones S, Bulacio, et al. Abstract 2.081|A.06. Evidence of Epideoptic Networks Activation and Modulation by Electrical Stimulation and Interstitial Ablation of Epileptic Nodes as Defined by SEEG Recordings. Presented at: American Epilepsy Society Annual Meeting; Dec. 4-8, 2015; Philadelphia.