Generic Name and Formulations:
Tranexamic acid 100mg/mL; soln for IV inj.
Indications for CYKLOKAPRON:
Short-term use in hemophilia to reduce or prevent hemorrhage, and reduce the need for replacement therapy during and following tooth extraction.
Adults and Children:
Give by IV inj. Max injection rate: 1mL/min. Pre-extraction: 10mg/kg; post-op: 10mg/kg 3–4 times daily for 2–8 days. Renal impairment: serum creatinine 1.36–2.83mg/dL: 10mg/kg twice daily; 2.83–5.66mg/dL: 10mg/kg once daily; >5.66mg/dL: 10mg/kg every 48hrs or 5mg/kg every 24hrs.
Acquired defective color vision. Subarachnoid hemorrhage. Active intravascular clotting.
Therapy longer than several days: do ophthalmologic exam (before and during); discontinue if visual changes occur. Risk of convulsions esp. during cardiovascular surgery or inadvertent neuraxial administration. Renal insufficiency; reduce dose. History of thromboembolic disease. Disseminated intravascular coagulation. Upper urinary tract bleeding. Pregnancy. Nursing mothers.
Plasminogen activation inhibitor.
Avoid concomitant Factor IX complex concentrates or Anti-inhibitor Coagulant concentrates; increased risk of thrombosis. Do not mix with solutions containing penicillin or with blood products.
GI upset, allergic dermatitis, giddiness, hypotension, visual abnormalities; thromboembolic events (rare), dizziness, convulsions, anaphylaxis.
Single-dose amps (10mL)—1, 10; single-dose vials (10mL)—10
Neurology Advisor Articles
- 5 Key Findings Presented at 2018 Parkinson Disease Conference
- Parkinson Disease and the Gut: Treatment Potential Abounds
- Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach
- Stroke-Code Patients With Low NIHSS Score, No Acute Imaging Findings Often Misdiagnosed
- Ethical Challenges of Nusinersen: Considerations When Counseling on Treatment
- Gender and Multiple Sclerosis: How It Influences Prognosis and Future Treatment
- Drug Prices Increase More Than Expected After Shortages
- Potentially Inappropriate Opioid Prescribing Tied to Overdose
- Loss of Function Variants in LRKK1 and LRKK2 Not Linked to Parkinson Disease
- Scribes Improve Physician Workflow, Patient Interaction