Archives: DiagnosticUpdate

Seropositivity to AQP4 distinguishes NMOSD from other demyelinating diseases, but some patients with NMOSD are AQP4 negative.

Fatigue is considered a multidimensional symptom of multiple sclerosis that remains one of the least understood and among the most difficult to diagnose and manage. This article explores current understanding of the pathophysiologic mechanisms of fatigue in multiple sclerosis and its differential diagnosis, both of which are critical for individualized management.