ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

DORYX
Acne
Bacterial infections
Malaria
Protozoal infections
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

DORYX Rx

Generic Name and Formulations:
Doxycycline (as hyclate) 50mg, 200mg; del-rel tabs.

Company:
Mayne Pharma US

Therapeutic Use:

Indications for DORYX:

Adjunct in severe acne.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs).

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. >8yrs (≤45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); (>45kg): use Adults dose.

Warnings/Precautions:

Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

YES

How Supplied:

Tabs 50mg—120; 200mg—60

Indications for DORYX:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma, specific bacterial (eg, relapsing fever). Alternative for selected infections when penicillin is contraindicated. Anthrax including inhalational anthrax (postexposure).

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs); if severe infections (eg, chronic UTI): 100mg every 12 hours. Streptococcal infections: treat for 10 days. Uncomplicated urethral or endocervical infection: 100mg twice daily or 200mg once daily for 7 days; rectal: 100mg twice daily for 7 days. Uncomplicated gonococcal infections (except anorectal infections in men): 100mg twice daily for 7 days or 300mg once, followed by a second 300mg dose 1hr later. Nongonococcal urethritis (NGU): 100mg twice daily for 7 days. Acute epididymo-orchitis: 100mg twice daily for at least 10 days. Syphilis (allergic to penicillin): Early: 100mg twice daily for 2 weeks; >1yr duration: treat for 4 weeks. Anthrax: 100mg twice daily for 60 days.

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. >8yrs (≤45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: up to 4.4mg/kg daily; (>45kg): use Adults dose. Anthrax (<45kg): 2.2mg/kg twice daily for 60 days; (≥45kg): use Adults dose.

Warnings/Precautions:

Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Note:

See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax.

Generic Availability:

YES

How Supplied:

Tabs 50mg—120; 200mg—60

Indications for DORYX:

Prophylaxis of malaria.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. Begin 1 or 2 days before travel to the malarious area, continue daily during travel and for 4 weeks after leaving the area. 100mg daily.

Children:

≤8yrs: not recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. Begin 1 or 2 days before travel to the malarious area, continue daily during travel and for 4 weeks after leaving the area. >8yrs: 2mg/kg once daily up to the adult dose.

Warnings/Precautions:

Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

YES

How Supplied:

Tabs 50mg—120; 200mg—60

Indications for DORYX:

Adjunct in acute intestinal amebiasis.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs).

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. >8yrs (≤45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); (>45kg): use Adults dose.

Warnings/Precautions:

Discontinue if severe skin reactions, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Monitor blood, renal, and hepatic function in long-term use. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

YES

How Supplied:

Tabs 50mg—120; 200mg—60

Sign Up for Free e-newsletters



CME Focus