Select therapeutic use:

Anaphylaxis:

Indications for ADRENALIN:

Emergency treatment of allergic reactions (Type I), including anaphylaxis.

Adults and Children:

Do not dilute. Inject into the anterolateral aspect of the thigh. ≥30kg: 0.3–0.5mg SC or IM; max: 0.5mg per inj. <30kg: 0.01mg/kg SC or IM; max: 0.3mg per inj. Both: may repeat every 5–10 mins as necessary; rotate inj sites. Monitor clinically for reaction severity and cardiac effects.

Warnings/Precautions:

Avoid injecting into the buttocks, digits, hands, feet, deltoid. Coronary artery disease. Cardiomyopathy. Hypertension. Hyperthyroidism. Parkinson's disease. Diabetes. Monitor BP frequently. IV: avoid extravasation. Elderly. Pregnancy. Labor & delivery: avoid during 2nd stage of labor or when maternal BP >130/80mmHg. Nursing mothers.

Pharmacologic Class:

Sympathomimetic.

Interactions:

Antagonized by α-blockers (eg, phentolamine), vasodilators (eg, nitrates), diuretics, antihypertensives, ergots, phenothiazine antipsychotics. Potentiated by other sympathomimetics, β-blockers (eg, propranolol), tricyclic antidepressants, MAOIs, COMT inhibitors (eg, entacapone), clonidine, doxapram, oxytocin. Increased arrhythmias with concomitant β-blockers, anesthetics (eg,halothane), antihistamines, thyroid hormones, diuretics, cardiac glycosides (eg, digitalis), quinidine. Hypokalemia with potassium-depleting diuretics, corticosteroids, theophylline.

Adverse Reactions:

Anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea, vomiting, headache, respiratory difficulties; pulmonary edema, renal impairment, arrhythmias; rare: serious infections at the inj site.

How Supplied:

Single-dose vials (1mL)—1, 25; Multi-dose vials (30mL)—1

Hypotension:

Indications for ADRENALIN:

To increase mean arterial blood pressure in adults with hypotension associated with septic shock.

Adult:

Dilute 1mg in 1000mL solution (1mcg/mL); see full labeling. Give by IV infusion after dilution. Initiate at 0.05–2mcg/kg/min; may titrate in increments of 0.05–0.2mcg/kg/min every 10–15mins to desired mean arterial pressure. After hemodynamic stabilization, may withdraw gradually.

Children:

Not established.

Warnings/Precautions:

Avoid injecting into the buttocks, digits, hands, feet, deltoid. Coronary artery disease. Cardiomyopathy. Hypertension. Hyperthyroidism. Parkinson's disease. Diabetes. Monitor BP frequently. IV: avoid extravasation. Elderly. Pregnancy. Labor & delivery: avoid during 2nd stage of labor or when maternal BP >130/80mmHg. Nursing mothers.

Pharmacologic Class:

Sympathomimetic.

Interactions:

Antagonized by α-blockers (eg, phentolamine), vasodilators (eg, nitrates), diuretics, antihypertensives, ergots, phenothiazine antipsychotics. Potentiated by other sympathomimetics, β-blockers (eg, propranolol), tricyclic antidepressants, MAOIs, COMT inhibitors (eg, entacapone), clonidine, doxapram, oxytocin. Increased arrhythmias with concomitant β-blockers, anesthetics (eg,halothane), antihistamines, thyroid hormones, diuretics, cardiac glycosides (eg, digitalis), quinidine. Hypokalemia with potassium-depleting diuretics, corticosteroids, theophylline.

Adverse Reactions:

Anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea, vomiting, headache, respiratory difficulties; pulmonary edema, renal impairment, arrhythmias; rare: serious infections at the inj site.

How Supplied:

Single-dose vials (1mL)—1, 25; Multi-dose vials (30mL)—1