Asthma/COPD:

Indications for BROVANA:

Long-term maintenance treatment of bronchoconstriction due to COPD. Limitations of use: not for treating asthma or acute deteriorations of COPD.

Adult:

By nebulizer: 15mcg by inhalation twice daily (AM & PM); max 30mcg/day. Use standard jet (eg, PARI LC Plus) nebulizer with air compressor (eg, PARI DURA-NEB 3000). Reevaluate periodically.

Children:

Not recommended.

Contraindications:

LABA use in asthma patients without use of long-term control medication.

Boxed Warning:

Asthma-related death.

Warnings/Precautions:

LABAs increase risk of asthma-related death. Do not exceed recommended dose. Discontinue if paradoxical bronchospasm or cardiovascular effects occur. Cardiovascular disease (esp. coronary insufficiency, arrhythmias, hypertension). Convulsive disorders. Hepatic impairment (monitor). Thyrotoxicosis. Hypokalemia. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Monitor potassium and blood glucose levels. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Pregnancy (Cat.C). Labor & delivery. Nursing mothers.

Pharmacologic Class:

Long-acting beta-2 agonist (LABA).

Interactions:

See Contraindications. Avoid other sympathomimetics (except short-acting bronchodilators). Caution with MAOIs, tricyclics, or drugs known to prolong the QTc interval; may increase risk of arrhythmias. Antagonized by β-blockers. K+-depleting diuretics, theophylline, aminophylline, steroids may potentiate hypokalemia.

Adverse Reactions:

Pain, chest pain, back pain, diarrhea, sinusitis, leg cramps, dyspnea, rash, flu syndrome, peripheral edema, lung disorder; cardiovascular effects (eg, increased pulse rate or BP, ECG changes); rarely: paradoxical bronchospasm, hypersensitivity reactions.

How Supplied:

Vials (2mL)—30, 60

Pricing for BROVANA

2ml of 15mcg/2ml vial (Qty: 60)
Appx. price $1029
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