Select therapeutic use:

Edema:

Indications for Chlorothiazide:

Edema.

Adult:

Initially 0.5g–1g once or twice daily; may give on intermittent schedule (every other day or 3–5 days/wk).

Children:

<6mos: up to 30mg/kg/day in 2 divided doses. ≥6mos: 10–20mg/kg/day in 1–2 divided doses. Max (<2yrs): 375mg/day; (2–12yrs): 1g/day.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Diuretic (thiazide).

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Tabs—100

Pricing for Chlorothiazide

250mg tablet (Qty: 30)
Appx. price $20
GoodRx

Hypertension:

Indications for Chlorothiazide:

Hypertension.

Adult:

0.5–1g/day as single or divided doses; max 2g/day.

Children:

<6mos: up to 30mg/kg/day in 2 divided doses. ≥6mos: 10–20mg/kg/day in 1–2 divided doses. Max (<2yrs): 375mg/day; (2–12yrs): 1g/day.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Diuretic (thiazide).

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Tabs—100

Pricing for Chlorothiazide

250mg tablet (Qty: 30)
Appx. price $20
GoodRx