Hereditary angioedema:

Indications for FIRAZYR:

For acute attacks of hereditary angioedema (HAE).

Adult:

≥18yrs: 30mg SC in abdominal area; may give additional doses at intervals of at least 6hrs if response inadequate or symptoms recur. Max 3 doses/24hrs.

Children:

<18yrs: not established.

Warnings/Precautions:

Advise patients to seek medical attention after treating laryngeal attack given the potential for airway obstruction. Elderly. Labor & delivery. Pregnancy. Nursing mothers.

Pharmacologic Class:

Bradykinin B2 receptor antagonist.

Interactions:

May attenuate the antihypertensive effect of ACE inhibitors.

Adverse Reactions:

Inj site reactions, pyrexia, transaminase increase, dizziness, rash.

Elimination:

Renal.

Generic Availability:

NO

How Supplied:

Single-use prefilled syringe (3mL)—1, 3