Indications for GLYSET:
Adjunct to diet in type 2 diabetes, alone or with a sulfonylurea.
Take with the first bite of each main meal. Initially 25mg three times daily; may start at 25mg once daily (to minimize GI effects) and gradually increase to 25mg three times daily. Increase to 50mg three times daily after 4–8 weeks; usual max 100mg three times daily.
Ketoacidosis. Inflammatory bowel disease. Colonic ulceration. Partial intestinal obstruction or predisposition thereof. Chronic intestinal diseases associated with marked disorders of digestion or absorption. Conditions that may deteriorate from increased intestinal gas formation.
Significant renal dysfunction (serum creatinine >2mg/dL): not recommended. Use glucose, not sucrose, to treat hypoglycemia. Stress. Monitor 1-hour postprandial blood glucose initially and during titration then glycosylated hemoglobin. Pregnancy (Cat.B): consider using insulin instead. Nursing mothers: not recommended.
Antagonized by intestinal adsorbents (eg, charcoal), pancreatin, amylase, other carbohydrate-splitting enzymes. May decrease levels of ranitidine, propranolol. Risk of hypoglycemia with concomitant sulfonylureas or insulin; consider reducing dose of these.
Transient flatulence, diarrhea, abdominal pain; low serum iron.