Indications for: IBSRELA
Irritable bowel syndrome with constipation (IBS-C).
Take immediately prior to breakfast (or the first meal of the day) and prior to dinner. 50mg twice daily.
<18yrs: not established.
Patients <6yrs of age. Known or suspected mechanical GI obstruction.
Avoid use in patients 6–<12yrs of age. Suspend dosing and rehydrate if severe diarrhea occurs. Pregnancy. Nursing mothers.
Sodium/hydrogen exchanger 3 (NHE3) inhibitor.
Antagonizes OATP2B1 substrates (eg, enalapril); monitor and increase dosage of substrates as needed.
Diarrhea, abdominal distension, flatulence, dizziness.
Generic Drug Availability: