Select therapeutic use:

Colorectal disorders:

Indications for LINZESS:

Irritable bowel syndrome with constipation (IBS-C).

Adult:

Swallow whole. Take on empty stomach, at least 30 mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 290mcg once daily.

Children:

<6yrs: contraindicated. 6–<18yrs: avoid.

Contraindications:

Children <6yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients.

Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

Pharmacologic Class:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Metabolism:

GI.

Elimination:

Fecal.

Generic Availability:

NO

How Supplied:

Caps—30

Pricing for LINZESS

145mcg capsule (Qty: 30)
Appx. price $428
GoodRx

Constipation and bowel cleansers:

Indications for LINZESS:

Chronic idiopathic constipation (CIC).

Adult:

Swallow whole. Take on empty stomach, at least 30 mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 145mcg once daily. A dosage of 72mcg once daily may be used based on individual presentation or tolerability.

Children:

<6yrs: contraindicated. 6–<18yrs: avoid.

Contraindications:

Children <6yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients.

Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

Pharmacologic Class:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Metabolism:

GI.

Elimination:

Fecal.

Generic Availability:

NO

How Supplied:

Caps—30

Pricing for LINZESS

145mcg capsule (Qty: 30)
Appx. price $428
GoodRx