Anemias:
Indications for LUPRON DEPOT 3.75mg:
Preoperative treatment of patients with anemia due to uterine leiomyomata (fibroids), with iron therapy if iron therapy alone is inadequate.
Adult:
Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. ≥18yrs: 3.75mg once a month for up to 3 months.
Children:
<18yrs: not applicable.
Contraindications:
Undiagnosed abnormal vaginal bleeding. Pregnancy (Cat.X). Nursing mothers. When coadministered with norethindrone acetate, its contraindications also apply to this combination regimen.
Warnings/Precautions:
Exclude pregnancy before starting; use nonhormonal contraception during therapy; discontinue if pregnancy occurs. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, anticonvulsants, corticosteroids); consider concomitant norethindrone acetate and supplemental calcium in endometriosis; assess BMD before retreatment. Depression. Missing successive doses may cause breakthrough bleeding or ovulation. Elderly.
See Also:
Pharmacologic Class:
GnRH analogue.
Adverse Reactions:
Hot flashes/sweats, headache, decreased libido, depression/emotional lability, dizziness, nausea/vomiting, pain, weight gain, vaginitis, amenorrhea, acne; bone density loss, convulsions; rare: anaphylaxis, asthma.
How Supplied:
Kit—1 (prefilled dual-chamber syringe w. supplies)
Endometriosis:
Indications for LUPRON DEPOT 3.75mg:
Endometriosis management, including pain relief and reduction of endometriotic lesions. With norethindrone acetate: for initial management and recurrent symptoms.
Adult:
Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. ≥18yrs: 3.75mg once a month for up to 6 months. May repeat one 6-month cycle; give with norethindrone acetate 5mg daily when retreating (do not use leuprolide alone for retreatment). Max total treatment: 12 months.
Children:
<18yrs: not applicable.
Contraindications:
Undiagnosed abnormal vaginal bleeding. Pregnancy (Cat.X). Nursing mothers. When coadministered with norethindrone acetate, its contraindications also apply to this combination regimen.
Warnings/Precautions:
Exclude pregnancy before starting; use nonhormonal contraception during therapy; discontinue if pregnancy occurs. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, anticonvulsants, corticosteroids); consider concomitant norethindrone acetate and supplemental calcium in endometriosis; assess BMD before retreatment. Depression. Missing successive doses may cause breakthrough bleeding or ovulation. Elderly.
See Also:
Pharmacologic Class:
GnRH analogue.
Adverse Reactions:
Hot flashes/sweats, headache, decreased libido, depression/emotional lability, dizziness, nausea/vomiting, pain, weight gain, vaginitis, amenorrhea, acne; bone density loss, convulsions; rare: anaphylaxis, asthma.
How Supplied:
Kit—1 (prefilled dual-chamber syringe w. supplies)
Miscellaneous Ob/Gyn conditions:
Indications for LUPRON DEPOT 3.75mg:
Preoperative treatment of patients with anemia due to uterine leiomyomata (fibroids), with iron therapy if iron therapy alone is inadequate.
Adult:
Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. ≥18yrs: 3.75mg once a month for up to 3 months.
Children:
<18yrs: not applicable.
Contraindications:
Undiagnosed abnormal vaginal bleeding. Pregnancy (Cat.X). Nursing mothers. When coadministered with norethindrone acetate, its contraindications also apply to this combination regimen.
Warnings/Precautions:
Exclude pregnancy before starting; use nonhormonal contraception during therapy; discontinue if pregnancy occurs. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, anticonvulsants, corticosteroids); consider concomitant norethindrone acetate and supplemental calcium in endometriosis; assess BMD before retreatment. Depression. Missing successive doses may cause breakthrough bleeding or ovulation. Elderly.
See Also:
Pharmacologic Class:
GnRH analogue.
Adverse Reactions:
Hot flashes/sweats, headache, decreased libido, depression/emotional lability, dizziness, nausea/vomiting, pain, weight gain, vaginitis, amenorrhea, acne; bone density loss, convulsions; rare: anaphylaxis, asthma.
How Supplied:
Kit—1 (prefilled dual-chamber syringe w. supplies)
