Indications for: MIACALCIN INJECTION
Paget's disease of bone. Hypercalcemia. Postmenopausal osteoporosis in women >5yrs postmenopausal.
Give by IM inj across multiple sites if total dose >2mL. Paget's: 100 IU SC or IM daily. Hypercalcemia: initially 4 IU/kg SC or IM every 12hrs, may increase after 1–2 days to 8 IU/kg every 12hrs, and then after 2 more days to max 8 IU/kg every 6hrs. Postmenopausal osteoporosis: 100 IU SC or IM daily.
MIACALCIN INJECTION Warnings/Precautions:
Correct hypocalcemia and other mineral metabolism disorders before initiating; monitor serum calcium and hypocalcemia symptoms during therapy. Increased risk of malignancies. Consider periodic exams of urine sediment; serum alkaline phosphatase and urinary hydroxyproline in Paget's. Postmenopausal osteoporosis: supplement diet with calcium 1g/day and Vit.D 400 IU/day. Re-evaluate periodically. Pregnancy. Nursing mothers.
MIACALCIN INJECTION Classification:
MIACALCIN INJECTION Interactions:
May antagonize lithium (consider lithium dose adjustment).
Nausea, vomiting, local inflammation, flushing, rash; hypersensitivity reactions, anaphylaxis, hypocalcemia, antibody formation.
Multi-dose vials (2mL)—1