CHF and arrhythmias:

Indications for NATRECOR:

Acutely decompensated CHF with dyspnea at rest or with minimal activity.

Adult:

2mcg/kg IV bolus once, then 0.01mcg/kg per minute by continuous IV infusion; limited experience with therapy >96 hours. Doses up to 0.03mcg/kg per minute have been used; see full labeling. Reduce dose or discontinue if symptomatic hypotension occurs.

Children:

Not established.

Contraindications:

Persistent systolic BP <100mmHg. Cardiogenic shock.

Warnings/Precautions:

Not recommended in significant valvular stenosis, restrictive or obstructive cardiomyopathy, constrictive pericarditis, pericardial tamponade, other conditions where vasodilators are inappropriate, or when cardiac output is dependent on venous return, or in patients with low cardiac filling pressures. Impaired renal function (esp if severe heart failure); monitor serum creatinine during and after therapy until stabilized. Monitor BP closely. Pregnancy. Nursing mothers.

Pharmacologic Class:

Vasodilator (human B-type natriuretic peptide).

Interactions:

Hypotension potentiated by ARBs and/or ACE inhibitors.

Adverse Reactions:

Hypotension, headache, nausea, back pain, dizziness; hypersensitivity.

Generic Availability:

NO

How Supplied:

Single-use vials—1