Parkinsonism:
Indications for ONGENTYS:
Adjunct to levodopa/carbidopa in patients with Parkinson's disease experiencing "off" episodes.
Adult:
Avoid food for 1hr before and at least 1hr after dose. 50mg once daily at bedtime. Hepatic impairment (moderate): 25mg once daily at bedtime; (severe): avoid.
Children:
Not established.
Contraindications:
Concomitant non-selective MAOIs (eg, phenelzine, isocarboxazid, tranylcypromine). Pheochromocytoma. Paraganglioma. Other catecholamine secreting neoplasms.
Warnings/Precautions:
Dyskinesias. Pre-existing somnolence or sleep disorders. Monitor for hypotension. Hallucinations, psychotic behaviors, impulse control/compulsive disorders; consider discontinuing if occur. Dopamine dysregulation syndrome. Moderate and severe hepatic impairment: see Adult dose. Severe renal impairment. ESRD: avoid. Pregnancy. Nursing mothers.
Pharmacologic Class:
COMT inhibitor.
Interactions:
See Contraindications. Reduce concomitant levodopa dose. Cardiac effects with drugs metabolized by COMT (eg, epinephrine, isoproterenol, norepinephrine, dopamine, dobutamine); caution and monitor. Reduced efficacy with some antipsychotics.
Adverse Reactions:
Dyskinesia, constipation, blood creatine kinase increased, hypotension/syncope, weight decreased; daytime sleepiness, withdrawal-emergent hyperpyrexia and confusion.
Generic Availability:
NO
How Supplied:
Caps—30
