Parkinsonism:

Indications for ONGENTYS:

Adjunct to levodopa/carbidopa in patients with Parkinson's disease experiencing "off" episodes.

Adult:

Avoid food for 1hr before and at least 1hr after dose. 50mg once daily at bedtime. Hepatic impairment (moderate): 25mg once daily at bedtime; (severe): avoid.

Children:

Not established.

Contraindications:

Concomitant non-selective MAOIs (eg, phenelzine, isocarboxazid, tranylcypromine). Pheochromocytoma. Paraganglioma. Other catecholamine secreting neoplasms.

Warnings/Precautions:

Dyskinesias. Pre-existing somnolence or sleep disorders. Monitor for hypotension. Hallucinations, psychotic behaviors, impulse control/compulsive disorders; consider discontinuing if occur. Dopamine dysregulation syndrome. Moderate and severe hepatic impairment: see Adult dose. Severe renal impairment. ESRD: avoid. Pregnancy. Nursing mothers.

Pharmacologic Class:

COMT inhibitor.

Interactions:

See Contraindications. Reduce concomitant levodopa dose. Cardiac effects with drugs metabolized by COMT (eg, epinephrine, isoproterenol, norepinephrine, dopamine, dobutamine); caution and monitor. Reduced efficacy with some antipsychotics.

Adverse Reactions:

Dyskinesia, constipation, blood creatine kinase increased, hypotension/syncope, weight decreased; daytime sleepiness, withdrawal-emergent hyperpyrexia and confusion.

Generic Availability:

NO

How Supplied:

Caps—30

Pricing for ONGENTYS

50mg capsule (Qty: 60)
Appx. price $1187
GoodRx