Indications for Probenecid + Colchicine:
Chronic gouty arthritis.
1 tab daily for 1 week, then 1 tab twice daily thereafter. Renal impairment, dose adjustments: see literature.
Probenecid + Colchicine Contraindications:
Acute gouty attack. Blood dyscrasias. Uric acid kidney stones. Children <2 yrs of age. Pregnancy. Concomitant salicylates (antagonizes uricosuric effect).
Probenecid + Colchicine Warnings/Precautions:
History of peptic ulcer. Spastic colon. GI, renal, hepatic, or hematological disorders. G6PD deficiency. Monitor blood counts in long-term therapy. Maintain adequate hydration. Alkalization of urine may be required. Debilitated. Elderly. Nursing mothers.
Probenecid + Colchicine Classification:
Uricosuric + antiinflammatory.
Probenecid + Colchicine Interactions:
Affects renal clearance of many drugs (esp. penicillins). Potentiates methotrexate (monitor and reduce methotrexate dose). May potentiate thiopental, ketamine, NSAIDs, oral sulfonylureas, acetaminophen, lorazepam, rifampin, other sulfonamides. Pyrazinamide antagonizes uricosuric effect. May cause falsely high readings of theophylline levels, or false (+) RBC or hemoglobin in urine.
Headache, dizziness, GI upset, diarrhea, urinary frequency, sore gums, uric acid kidney stones, dermatitis, hematuria, renal colic, fever, peripheral neuritis, myopathy, anemia, blood dyscrasias, hemolytic anemia, purpura, bone marrow depression; rare: severe allergic reactions, anaphylaxis.
Formerly known under the brand name Colbenemid.