Indications for Probenecid:
Hyperuricemia associated with gout and gouty arthritis.
250mg twice daily for 1 week, then 500mg twice daily thereafter. Renal impairment, dose adjustments: see literature.
Acute gouty attack. Blood dyscrasias. Uric acid kidney stones. Children <2 yrs of age. Concomitant salicylates (antagonizes uricosuric effect).
History of peptic ulcer. Renal insufficiency. G6PD deficiency. Maintain adequate hydration. Alkalization of urine may be required. Pregnancy.
Affects renal clearance of many drugs (esp. penicillins). Potentiates methotrexate (monitor and reduce methotrexate dose). May potentiate thiopental, ketamine, NSAIDs, oral sulfonylureas, acetaminophen, lorazepam, rifampin, other sulfonamides. Pyrazinamide antagonizes uricosuric effect. May cause falsely high readings of theophylline levels.
Headache, dizziness, GI upset, urinary frequency, sore gums, uric acid kidney stones, dermatitis, fever, hematuria, renal colic, blood dyscrasias, hemolytic anemia; rare: severe allergic reactions, anaphylaxis.
Formerly known under the brand name Benemid.