Constipation and bowel cleansers:
Indications for SUTAB:
Bowel cleansing prior to colonoscopy.
Split-dose regimen (1st dose start the evening before colonoscopy): 12 tabs with 16oz of water over 15–20mins; approx. 1hr after the last tab is ingested, drink additional 16oz of water over 30mins; then approx. after 30mins, drink another 16oz of water over 30mins; (2nd dose start next morning): repeat on day of colonoscopy 5–8hrs before procedure and no sooner than 4hrs from starting Dose 1. Total regimen: 24 tabs. Complete all tabs and water at least 2hrs before colonoscopy.
GI obstruction or ileus. Bowel perforation. Toxic colitis. Toxic megacolon. Gastric retention.
Maintain adequate hydration. Correct fluid and electrolyte abnormalities before therapy. Renal impairment; monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. History of QT prolongation, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History of seizures. Hyponatremia. Inflammatory bowel disease. Colonic mucosal ulcerations. Ischemic colitis. Severe ulcerative colitis. Elderly. Pregnancy. Nursing mothers.
Caution with concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal: may increase risk of seizures. Caution with drugs that may increase risk for fluid or electrolyte disturbances, arrhythmias or QT prolongation. Administer oral medications at least 1hr before starting each dose of Sutab. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2hrs before and not less than 6hrs after Sutab to avoid chelation with magnesium. Avoid concomitant stimulant laxatives (eg, bisacodyl, sodium picosulfate).
Nausea, abdominal distension, vomiting, upper abdominal pain; electrolyte abnormalities, renal injury.
Generic Drug Availability:
Tabs—24 (w. 16oz container)