Indications for VANCOCIN:
Clostridioides difficile-associated diarrhea. Enterocolitis due to Staphylococcus aureus.
C. difficile-associated diarrhea: 125mg 4 times a day for 10 days. Enterocolitis: 500mg–2g per day in 3–4 divided doses for 7–10 days.
Both: usually 40mg/kg per day in 3–4 divided doses for 7–10 days; max 2g/day.
Renal insufficiency and/or colitis. Inflammatory bowel disorders. Underlying hearing loss. Monitor hearing, blood, renal function. Consider monitoring vancomycin serum concentrations. Elderly. Pregnancy. Nursing mothers.
Monitor with aminoglycosides, other neurotoxic, nephrotoxic, or ototoxic drugs.
Nausea, abdominal pain, hypokalemia, drug fever, urticaria, rash (may be serious, eg, Stevens-Johnson syndrome), ototoxicity, nephrotoxicity, eosinophilia, anaphylaxis, blood dyscrasias; rare: interstitial nephritis, vertigo.