Asthma/COPD:
Indications for YUPELRI:
Maintenance treatment of COPD.
Adult Dosage:
Administer by the orally inhaled route via standard jet nebulizer connected to an air compressor. Inhale 1 vial (175mcg) once daily (using a mouthpiece).
Children Dosage:
Not established.
YUPELRI Warnings/Precautions:
Do not initiate during acutely deteriorating or potentially life-threatening COPD episodes. Not for treating acute symptoms. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Do not exceed recommended dose. Discontinue immediately and treat if paradoxical bronchospasm or immediate hypersensitivity reactions occur; use alternative therapy. Narrow-angle glaucoma. Urinary retention. Prostatic hyperplasia. Bladder-neck obstruction. Hepatic impairment: not recommended. Severe renal impairment: monitor. Pregnancy. Nursing mothers.
YUPELRI Classification:
Long-acting anticholinergic.
YUPELRI Interactions:
Additive effects with concomitant other anticholinergic-containing drugs; avoid. Concomitant OATP1B1 and OATP1B3 inhibitors (eg, rifampicin, cyclosporine): not recommended.
Adverse Reactions:
Cough, nasopharyngitis, upper respiratory tract infection, headache, back pain; paradoxical bronchospasm.
Generic Drug Availability:
NO
How Supplied:
Vials (3mL)—7, 30