Sleep-wake disorders:

Indications for ZOLPIMIST:

Short-term treatment of insomnia characterized by difficulties with sleep initiation.


Individualize. Give once daily immediately before bedtime. 10mg (two actuations). Max 10mg/day. Elderly, debilitated, or hepatic impaired: 5mg (one actuation); monitor closely. Concomitant CNS depressants: use downward dose adjustments. Effects delayed if used with or immediately after a meal.


Not established.


Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Abnormal thinking and behavioral changes. Renal or hepatic impairment. Conditions that affect metabolism or hemodynamic response. Compromised respiratory function. Sleep apnea. Myasthenia gravis. Drug abusers. Write ℞ for smallest practical amount. Withdraw gradually. Elderly (higher risk of falls). Debilitated. Pregnancy (Cat.C). Nursing mothers.

Pharmacologic Class:

Imidazopyridine hypnotic.


Additive effects with concomitant other CNS depressants (eg, imipramine, chlorpromazine), or alcohol (avoid); reduce dose. Potentiated by potent CYP3A4 inhibitors (eg, ketoconazole); reduce zolpidem dose. Antagonized by CYP3A4 inducers (eg, rifampin).

Adverse Reactions:

Drowsiness, dizziness, diarrhea, drugged feeling, headache; CNS effects, complex behaviors (eg, sleep-driving), hallucinations, amnesia, anxiety, other neuropsychiatric symptoms; anaphylaxis, angioedema.

Generic Availability:


How Supplied:

Pump (60 metered actuations)—1

Pricing for ZOLPIMIST

4.5ml of 5mg/spray bottle of spray (Qty: 1)
Appx. price $335