Drug Name:
ELITEK Rx
Generic Name and Formulations:
Rasburicase (recombinant) 1.5mg, 7.5mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains mannitol.
Company:
Sanofi U.S.
Therapeutic Use:
Indications for ELITEK:
Single course treatment for initial management of plasma uric acid levels in patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anti-cancer therapy expected to result in tumor lysis and subsequent elevation of plasma uric acid.
Adults and Children:
Give by IV infusion over 30 mins. 0.2mg/kg daily for 5 days. Dosing >5 days or more than one course of treatment: not recommended.
Contraindications:
History of anaphylaxis, or development of hemolytic reactions or methemoglobinemia to rasburicase. G6PD deficiency.
Boxed Warning:
Anaphylaxis. Hemolysis. Methemoglobinemia. Interference with uric acid measurements.
Warnings/Precautions:
Discontinue permanently if serious hypersensitivity reactions (including anaphylaxis), hemolysis, or methemoglobinemia develops. Screen high risk patients (eg, African or Mediterranean ancestry) for G6PD deficiency prior to initiation. Pregnancy (Cat.C); avoid. Nursing mothers: not recommended.
Pharmacological Class:
Urate oxidase.
Interactions:
Interferes with uric acid measurements in blood samples left at room temperature.
Adverse Reactions:
GI upset, pyrexia, peripheral edema, anxiety, headache, abdominal pain, constipation, hypophosphatemia, hyperbilirubinemia, mucositis, sepsis; anaphylaxis, hemolysis, methemoglobinemia.
Generic Availability:
NO
How Supplied:
Single-use vials 1.5mg—3 (w. diluent); 7.5mg—1 (w. diluent)
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