Epilepsy News Archive

Acetaminophen Is Safe, May Be Effective to Reduce Febrile Seizure Recurrence

Acetaminophen Is Safe, May Be Effective to Reduce Febrile Seizure Recurrence

Investigators sought to determine whether rectal acetaminophen reduces rates of second febrile seizure in children during the same febrile illness when given rectally shortly after initial seizure.

Oxtellar XR Gains Monotherapy Indication for Partial-Onset Seizures

Oxtellar XR Gains Monotherapy Indication for Partial-Onset Seizures

The FDA has approved the supplemental New Drug Application for Oxtellar XR to include monotherapy use for the treatment of partial-onset seizures patients aged ≥6 years.

Volume Perfusion CT Helps Differentiate Ictal Stroke Mimics, but Not Postictal, From Acute Ischemic Stroke

Volume Perfusion CT Helps Differentiate Ictal Stroke Mimics, but Not Postictal, From Acute Ischemic Stroke

Patients were initially misjudged to have presented with an acute stroke instead of an epileptic seizure.

Unplanned Pregnancy in Women With Epilepsy Increases Risk for Spontaneous Fetal Loss

Unplanned Pregnancy in Women With Epilepsy Increases Risk for Spontaneous Fetal Loss

Investigators assessed the effect of unplanned vs planned pregnancies in this patient population on the risk for SFL.

Epilepsy, Sleep Apnea, and SUDEP: A Closer Look

Epilepsy, Sleep Apnea, and SUDEP: A Closer Look

The comorbid presence of central apnea has been identified by multiple researchers as predictive of SUDEP.

Study Identifies Early-Onset Motor Behaviors in DES-Triggered Seizures

Study Identifies Early-Onset Motor Behaviors in DES-Triggered Seizures

Investigators evaluated seizure stimulation parameters, electroclinical data, semiology, and anatomical localization in spontaneous and stimulated seizures.

NBEA Gene Associated With Neurodevelopmental Delay, Childhood Epilepsy

NBEA Gene Associated With Neurodevelopmental Delay, Childhood Epilepsy

Investigators analyzed the NBEA gene to determine whether or not it could be a biomarker for early childhood epilepsy.

Myoclonic-Atonic Seizures and Lennox-Gastaut Syndrome Present With Overlapping Features, Difficulty in Diagnosis

Myoclonic-Atonic Seizures and Lennox-Gastaut Syndrome Present With Overlapping Features, Difficulty in Diagnosis

Patients with a higher number of Lennox-Gastaut syndrome traits had a greater likelihood of ongoing seizures, and each additionally observed Lennox-Gastaut syndrome trait was associated with half the likelihood of achieving seizure freedom.

SISCOM Hyperperfusion Identifies Epilepsy Lateralization

SISCOM Hyperperfusion Identifies Epilepsy Lateralization

Compared with nonmotor seizures, there was a significant difference with basal ganglia and thalamus coactivation in terms of seizures with elementary motor signs and automatisms.

Lorcaserin May Reduce Motor Seizures in Pediatric Treatment-Resistant Epilepsy

Lorcaserin May Reduce Motor Seizures in Pediatric Treatment-Resistant Epilepsy

Lorcaserin may reduce seizure frequency in patients with Dravet syndrome and severe childhood-onset epilepsies.

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

The study utilized the Vaccine Safety Datalink and included children who received the first dose of a measles-containing vaccine between 12 and 23 months old during the study period of January 1, 2003 to September 20, 2015.

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

Investigators assessed the frequency of bilateral independent periodic discharges in patients experiencing electrographic seizures and their effect on patient mortality and clinical outcomes.

Difficultly Distinguishing Drowning-Related Deaths From SUDEP

Difficultly Distinguishing Drowning-Related Deaths From SUDEP

Researchers examined a database of seizure-related deaths to determine whether cause was drowning or sudden unexpected death in epilepsy.

Oral Film Formulation of Clobazam Gets FDA Approval for LGS

Oral Film Formulation of Clobazam Gets FDA Approval for LGS

Aquestive Therapeutics announced that the FDA has approved Sympazan oral film as adjunctive treatment of seizures associated with LGS in patients aged ≥2 years old.

Circadian, Circaseptan Rhythms Prevalent in Epileptic Seizure Cycles

Circadian, Circaseptan Rhythms Prevalent in Epileptic Seizure Cycles

Researchers used analytic techniques from circular statistics to quantify the prevalence, frequency, and strength of seizure cycles in patients with epilepsy.

Resective Epilepsy Surgery Reduces Seizures, Improves Social Functioning in Lennox-Gastaut Syndrome

Resective Epilepsy Surgery Reduces Seizures, Improves Social Functioning in Lennox-Gastaut Syndrome

Better social competence and adaptive behavior was achieved by seizure-free patients at post-surgery follow-ups compared with patients with persistent seizures (P <.05).

Combining Vigabatrin, Hormone Therapy Effective for Infantile Spasms

Combining Vigabatrin, Hormone Therapy Effective for Infantile Spasms

Results suggest that prednisolone may be associated with a reduced chance of achieving electroclinical response when compared with tetracosactide.

Epidiolex Now Available to Treat Seizures Associated With LGS, Dravet Syndrome

Epidiolex Now Available to Treat Seizures Associated With LGS, Dravet Syndrome

The Food and Drug Administration (FDA) approved the treatment in June 2018, making it the first prescription pharmaceutical formulation of highly-purified, plant-derived cannabidiol, as well as the first treatment indicated for patients with Dravet syndrome.

Predictors for Epilepsy Following Acute Symptomatic Neonatal Seizures Remain Elusive

Predictors for Epilepsy Following Acute Symptomatic Neonatal Seizures Remain Elusive

The researchers sought to identify risk factors for seizures in this population by reviewing hospital records.

High-Frequency Oscillations Not a Good Predictor of Outcomes After Epilepsy Surgery

High-Frequency Oscillations Not a Good Predictor of Outcomes After Epilepsy Surgery

HFOs were predictors of good or poor surgical outcome in 69.2% of patients, resulting in a modest validation of the researchers' hypothesis.

Unintended Pregnancy Common in Women With Epilepsy

Unintended Pregnancy Common in Women With Epilepsy

It is likely that both maternal age and socioeconomic status contribute to the higher rates of pregnancy in WWE compared with women without epilepsy.

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures

Safety data for Fycompa was consistent with the safety profile in adult populations without the need for weight-based dosing.

DEA Reschedules Marijuana-Based Drug Epidiolex

DEA Reschedules Marijuana-Based Drug Epidiolex

Drugs with a Schedule V classification have proven medical use and low abuse potential.

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures

The Company states that the NDA is supported by robust clinical trial data, including patients studies where more than 1600 seizures were treated with Valtoco nasal spray.

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children

The odds of language delay were lower at 18 months and 36 months in children exposed to AEDs in utero whose mothers took folic acid.

Significant Variations in Epilepsy Surgical Strategy, Deficit Reporting Exist

Significant Variations in Epilepsy Surgical Strategy, Deficit Reporting Exist

This widespread variation in strategies may contribute to undesirable outcomes that are characterized by poor seizure control and added deficits.

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies

Although 2 patients experienced an increase in seizure frequency, the remaining patients did not experience a change in frequency.

Add-On Cannabidiol Reduces Seizure Frequency in Treatment-Refractory Epilepsy

Add-On Cannabidiol Reduces Seizure Frequency in Treatment-Refractory Epilepsy

Countable seizure types were recorded in parents' and caregivers' clinical diaries during a 4-week baseline period.

Clinical Factors Influencing Neuroimaging Yield in Nonindex Seizures Identified

Clinical Factors Influencing Neuroimaging Yield in Nonindex Seizures Identified

The investigators sought to detect whether neuroimaging during an emergency department visit was associated with acute changes in the management of patients.

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes

The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy

Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.

Sympazan Oral Film Granted Tentative Approval for Lennox-Gastaut Syndrome

Sympazan Oral Film Granted Tentative Approval for Lennox-Gastaut Syndrome

Clobazam is currently available as oral tablets and suspension under the trade name Onfi (Lundbeck).

Everolimus, Sirolimus Generally Safe for Epilepsy in Tuberous Sclerosis Complex

Everolimus, Sirolimus Generally Safe for Epilepsy in Tuberous Sclerosis Complex

Approximately 78% of treated patients experienced at least 1 treatment-related adverse event.

Anticonvulsants Not Associated With Risk for Perinatal Bleeding

Anticonvulsants Not Associated With Risk for Perinatal Bleeding

The findings offer some reassurance for clinicians and for pregnant women who are successfully treated with enzyme-inducing ACDs.

Diacomit Approved for the Treatment of Dravet Sydrome

Diacomit Approved for the Treatment of Dravet Sydrome

Diacomit was evaluated in 2 multicenter, placebo-controlled, double-blind, randomized studies.

Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy

Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy

The results of this review are applicable primarily to persons with focal onset seizures, with 88% of included participants experiencing this type of seizure at baseline.

High Anxiety Symptoms Prevalent in Epilepsy, Mesial Temporal Sclerosis

High Anxiety Symptoms Prevalent in Epilepsy, Mesial Temporal Sclerosis

Investigators assessed demographic and epilepsy-specific factors independently associated with anxiety, including lesions and seizure focus localization.

Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines

Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines

An expert subcommittee was formed consisting of members of the AAN and AES to update the 2004 evidence-based guidelines on epilepsy treatment with AEDs.

New Formulation of Status Epilepticus Treatment To Be Reviewed

New Formulation of Status Epilepticus Treatment To Be Reviewed

The NDA for IM/IV Captisol-Enabled Fosphenytoin has been accepted for review and given a Prescription Drug Fee User Act date, by the FDA.

Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy

Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy

Potentially modifiable risk factors in midlife are associated with the risk of developing late-onset epilepsy.

Disease-Specific ICD Code Helps Identify Infantile Spasms in Claims Data

Disease-Specific ICD Code Helps Identify Infantile Spasms in Claims Data

Claims data spanning 4 years were obtained from a pediatric accountable care organization.

Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed

Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed

The safety and efficacy of clobazam monotherapy in patients with new-onset focal or generalized seizures was investigated in a new Cochrane systematic review.

Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus

Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus

The efficacy was reported to be significantly higher in patients who had taken benzodiazepines.

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.

Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms

Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms

The FDA has approved an abbreviated New Drug Application for Vigadrone, the generic alternative to Sabril powder for oral solution.

Significant Changes in Serotonin Levels Observed Following Epileptic Seizures

Significant Changes in Serotonin Levels Observed Following Epileptic Seizures

Investigators sought to examine whether seizures are capable of causing changes in serotonin levels in the peripheral circulation.

Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

Next-generation sequencing can improve treatment efficacy and reduce hospitalization in children with drug-resistant epilepsy.

First Marijuana-Based Drug Approved to Treat LGS, Dravet Syndrome

First Marijuana-Based Drug Approved to Treat LGS, Dravet Syndrome

This marks the first approved drug that contains an active ingredient derived from marijuana as well as the first treatment approved for patients with Dravet syndrome.

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Short-term administration of carbapenem antibiotics may be beneficial in the treatment of VPA overdose in patients with no history of seizure disorder.

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

The primary efficacy outcome was achieved in a higher percentage of patients in the exposure range of 9 to 15 ng/mL compared with patients in the 3 to 7 ng/mL and >7 to 9 ng/mL ranges.

Women With Epilepsy More Likely to Have Major Depressive Disorder

Women With Epilepsy More Likely to Have Major Depressive Disorder

Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.

Fycompa Granted Priority Review for Pediatric Indications

Fycompa Granted Priority Review for Pediatric Indications

The sNDA included data from Study 311 (N=180), an ongoing, open-label, multicenter trial with an extension phase that evaluated the safety, tolerability, and exposure-efficacy relationship of Fycompa oral suspension as adjunctive therapy in children (4 to 11 years) with inadequately controlled POS or PGTC seizures.

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

The results of this study should help reassure and encourage women with epilepsy without a prior diagnosis of infertility or an associated disorder who are seeking pregnancy.

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

The effects of short-term VPA exposure on placental compound carrier expression were examined in this study.

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

A majority of participants (67%) had reported seeing a neurologist or epilepsy specialist in the past year, with younger adults comprising a higher percentage of these participants.

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

The expanded approval was supported by extrapolated efficacy data from placebo-controlled studies in adults with partial-onset seizures.

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

The prevalence of major congenital malformations in offspring who are prenatally exposed to antiepileptic drugs is highest among those exposed to carbamazepine, phenobarbital doses of >80 mg/day, valproate of ≤650 mg/day, and levetiracetam at 250 to 4000 mg/day.

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

The approval was based on a 12-week, double-blind, placebo-controlled study (N=295) in pediatric patients 4-17 years of age.

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

The approval is specifically for bilateral anterior thalamic nucleus stimulation and is based on results from the SANTE study (Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy).

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Although most adults with epilepsy report taking epilepsy medication, less than half of those report having their seizures controlled.

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

Researchers evaluated the use of genetic screening to identify individuals who are at risk for carbamazepine-induced cutaneous adverse drug reactions.

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

Investigators conducted a population-based study to assess risk and cause of unnatural mortality in individuals with epilepsy.

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

Clinicians should conduct a medical evaluation as soon as suspicious symptoms are reported and discontinue lamotrigine if HLH is suspected.

Listening to Sonified EEG Fluctuations May Help Identify Silent Seizures

Listening to Sonified EEG Fluctuations May Help Identify Silent Seizures

In the event where electroencephalograms featured either seizures or seizure-like patterns, nonexpert medical students who auditorily reviewed the electroencephalograms rated samples as seizures with a higher degree of specificity vs experts or nonexpert medical students.

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

Cannabidiol may be effective as add-on treatment for drop seizures associated with Lennox-Gastaut syndrome.

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

The FDA has approved Afinitor Disperz for the adjunctive treatment of patients aged ≥2 years with TSC-associated partial-onset seizures.

Increased Risk of Unnatural Death in People With Epilepsy

Increased Risk of Unnatural Death in People With Epilepsy

The risk of unnatural death is increased among people with epilepsy.

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

Because of the small size of the study sample, the findings may be limited to this patient population and may be hard to generalize across all pediatric patients with Dravet syndrome.

EEG Changes in Pediatric BECTS Promoted by Treatment With Levetiracetam, Sulthiame

EEG Changes in Pediatric BECTS Promoted by Treatment With Levetiracetam, Sulthiame

The small sample size included in the study precludes the ability to make generalized statements about electroencephalogram pattern characteristics in the entire pediatric patient population with BECTS.

Early-Life Epilepsy Should Be Urgently Treated With EBM

Early-Life Epilepsy Should Be Urgently Treated With EBM

Best diagnostics and evidence-based treatments should be used from the start of the disease.

Educational Attainment Down With In Utero Exposure to AEDs

Educational Attainment Down With In Utero Exposure to AEDs

Exposure to sodium valproate or a combination of antiepileptic drugs in utero is associated with worse attainment on national educational tests.

Fycompa sNDA Submitted for Pediatric Seizure Indications

Fycompa sNDA Submitted for Pediatric Seizure Indications

The proposed pediatric indications are based on a 2018 Draft Guidance that supports extrapolating efficacy data of approved drugs to treat POS in adults to pediatric patients aged ≥4 years.

Epilepsy Associated With Greater Risk for Serious Transportation Accidents

Epilepsy Associated With Greater Risk for Serious Transportation Accidents

The registers used in this study did not collect information on whether individuals with epilepsy were actually responsible for the transportation accidents.

Cannabinoids May Be Effective as Adjunctive Treatment for Refractory Epilepsy

Cannabinoids May Be Effective as Adjunctive Treatment for Refractory Epilepsy

Pharmaceutical-grade CBD used as adjunctive therapy in patients with pediatric-onset drug-resistant epilepsy may reduce the frequency of seizures.

Older Epilepsy Patients More Likely to Experience AED, Non-AED Drug Interaction

Older Epilepsy Patients More Likely to Experience AED, Non-AED Drug Interaction

The findings are limited to the 50 most-prescribed non-epilepsy drugs assessed in this Medicare population and may not generalize to non-Medicare beneficiaries who receive other non-epilepsy drugs.

More Evidence Supports Benefits of Cannabidiol for Treatment-Resistant Epilepsy

More Evidence Supports Benefits of Cannabidiol for Treatment-Resistant Epilepsy

Cannabinoids are effective as an adjunctive treatment for reducing seizure frequency in pediatric-onset treatment-resistant epilepsy.

Behavioral Interventions May Have Some Benefit in Refractory Epilepsy

Behavioral Interventions May Have Some Benefit in Refractory Epilepsy

Participants in the progressive muscle relaxation group reported greater reductions in stress vs those randomized to the focused-attention activity.

Vitamin D Supplement May Benefit Bone Health in Epilepsy

Vitamin D Supplement May Benefit Bone Health in Epilepsy

Five studies demonstrated a significant improvement in serum 25-hydroxyvitamin D from baseline to post-treatment vitamin D supplementation in patients with epilepsy.

Levetiracetam Associated With Less Monotherapy Failure in Infantile Seizures

Levetiracetam Associated With Less Monotherapy Failure in Infantile Seizures

The study findings are particularly relevant given the current mismatch between clinical practice and regulatory approval of levetiracetam in infantile seizures.

Consensus Statement: Defining Pediatric Status Epilepticus Syndromes

Consensus Statement: Defining Pediatric Status Epilepticus Syndromes

The investigators hope that the consensus statement helps resolve several clinical questions in cases of pediatric new onset status epilepticus syndromes.

Exposure to Valproate During Pregnancy May Have Effect on Offspring's School Performance

Exposure to Valproate During Pregnancy May Have Effect on Offspring's School Performance

School performance is lower in children with prenatal exposure to valproate.

Seizure Frequency May Lessen With Stress Reduction

Seizure Frequency May Lessen With Stress Reduction

Participants recorded daily mood and stress ratings plus seizure counts using an electronic diary and medication adjustments were not allowed.

Chronic Traumatic Encephalopathy Uncommon in Treatment-Refractory Epilepsy

Chronic Traumatic Encephalopathy Uncommon in Treatment-Refractory Epilepsy

While epilepsy-related head trauma was common, 9 of 10 patients displayed no evidence of CTE.

FDA Approves Smart Watch for Epilepsy Management

FDA Approves Smart Watch for Epilepsy Management

The FDA has cleared the Embrace smart watch for managing epilepsy.

Cannabidiol Reduces Drop Seizures in Lennox-Gastaut Syndrome

Cannabidiol Reduces Drop Seizures in Lennox-Gastaut Syndrome

Add-on cannabidiol is associated with reduced monthy drop seizure frequency in patients with Lennox-Gastaut sydrome associated drop seizures.

Focal Epilepsy Linked to Increased Risk for Mood Disorders

Focal Epilepsy Linked to Increased Risk for Mood Disorders

Clinicians should evaluate their patients, especially patients with focal epilepsy, for mood disorders.

High Doses of Topiramate for Epilepsy in Pregnancy Increase Risks for Oral Clefts in Offspring

High Doses of Topiramate for Epilepsy in Pregnancy Increase Risks for Oral Clefts in Offspring

Women receiving topiramate for epilepsy were exposed to high cumulative doses, increasing the risk for oral clefts in offspring.

Seizure Control Diminishes With Subsequent Antiepileptic Drug Therapy

Seizure Control Diminishes With Subsequent Antiepileptic Drug Therapy

Patients with tough-to-treat seizures may require nonpharmacologic treatment such as resective surgery.

More Than One-Third of New Cases of Epilepsy Are Treatment Refractory

More Than One-Third of New Cases of Epilepsy Are Treatment Refractory

Over one-third of patients with newly diagnosed epilepsy do not respond to antiepileptic drug treatment.

Treating Levetiracetam-Induced Behavioral Effects With Vitamin B6

Treating Levetiracetam-Induced Behavioral Effects With Vitamin B6

Vitamin B6 was found to effectively treat the behavioral adverse effects seen with levetiracetam.

Myoclonus Reported With Gabapentin, Pregabalin Use

Myoclonus Reported With Gabapentin, Pregabalin Use

Research has found that gabapentin and pregabalin induced myoclonus is often seen but is rarely documented.

Evaluating Antiepileptic Drug Safety in Elderly Patients

Evaluating Antiepileptic Drug Safety in Elderly Patients

Lamotrigine and levetiracetam are just as effective as other AEDs, and are better tolerated as well.

Cannabidiol Under Priority Review for Treatment of Lennox-Gastaut, Dravet Syndromes

Cannabidiol Under Priority Review for Treatment of Lennox-Gastaut, Dravet Syndromes

The FDA has accepted for filing with Priority Review the NDA for cannabidiol as seizure treatment.

Prepregnancy Seizure History May Predict Antepartum Seizure Risk

Prepregnancy Seizure History May Predict Antepartum Seizure Risk

The findings emphasize the importance of seizure control before pregnancy in women with epilepsy.

Brodmann Area 25 May Play Pivotal Role in Controlling Blood Pressure

Brodmann Area 25 May Play Pivotal Role in Controlling Blood Pressure

Stimulation of the other brain structures resulted in no significant blood pressure changes among the studied participants.

Severe Refractory Focal Epilepsy May Benefit From Add-On Perampanel

Severe Refractory Focal Epilepsy May Benefit From Add-On Perampanel

In patients with severe refractory focal epilepsy, add-on treatment with perampanel may be beneficial.

Identifying Pediatric Seizures With Hemispheric Regional Cerebral Oxygen Saturation

Identifying Pediatric Seizures With Hemispheric Regional Cerebral Oxygen Saturation

The findings further the utility of cerebral oximetry as a neurological assessment tool.

Reducing Seizure Frequency in Dravet Syndrome With Low-Dose Fenfluramine

Reducing Seizure Frequency in Dravet Syndrome With Low-Dose Fenfluramine

ZX008 has received Orphan Drug designation and Fast Track designation by the FDA for the treatment of Dravet syndrome.

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