Epilepsy increases risk of venous thromboembolism
the Neurology Advisor take:
People with epilepsy have risk factors associated with venous thromboembolism (VTE) independent of chronic neurologic illnesses, according to a study published in Epilepsia.
Gabriel U. Martz, MD, of the Medical University of South Carolina and colleagues investigated patients with epilepsy and patients with migraines, finding that those with epilepsy had an elevated risk of VTE. Previously, the risk of VTE in patients with epilepsy had not been studied.
All inpatient, ED, and hospital-based outpatient encounters in South Carolina from Jan. 1, 2000 through Dec. 31, 2011 were included in the study. The primary outcome variable of VTE was defined as having a diagnosis of VTE at or after the diagnosis of epilepsy or migraine.
Overall, 97,900 people with epilepsy and 138,497 people with migraines, a comparable neurologic condition, were evaluated. VTE occurred in 2.7% of the patients with epilepsy and in 0.6% of the patients with migraine.
VTE also had a strong association with higher numbers of comorbidities. Comorbidities occurred in 52% of patients with epilepsy compared with 23% of people with migraines. However, the impact of comorbidities on VTE risk was larger in patients with migraines.
Taking all factors into account, VTE occurrence in people with epilepsy is similar to that of people with cancer, the researchers concluded.
A loose blood clot in a venous thromboembolism.
- A total of 138,497 people with migraine (PWMs) and 67,900 PWEs (32,186 DE, 35,714 PE) were included.
- VTE occurred in 2.7% of PWEs (4.2% among DE), and 0.6% of PWMs.
- The hazard ratio for VTE in DE compared with PWMs was 3.08 (95% CI 2.76-3.42), adjusted for all covariables.
- Higher numbers of comorbidities were strongly associated with VTE.
- PWE had higher numbers of comorbidities (52% with 2+ comorbidities versus 23% of PWM), but the impact of comorbidities on VTE risk was larger in PWM.
Next Article in Epilepsy
Neurology Advisor Articles
- Some Statins May Be Associated With Cognition, Memory Deficits
- Neuropathic Pain Treatments
- New Monoclonal Antibody BAN2401 Reduces Amyloid Plaques, Improves Cognition in Alzheimer's
- Nonpharmacologic Interventions for Alzheimer's Have Greater Impact on Outcomes Than Currently Available Medications
- Vagus Nerve Stimulation in Pediatric Epilepsy: Weighing the Risks and Benefits
- OnabotulinumtoxinA for Post-Stroke Spasticity: Treatment Strategies and Limitations
- Tau Associated With Loss of Anterior Temporal White Matter Integrity
- Location Probability Learning Unimpaired in Parkinson Disease
- Prenatal Tdap Vaccination Not Linked to Autism Risk
- AMA Adopts Policy to Advance Gender Equity in Medicine