Epilepsy and Seizures

Featured Article

Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

In individuals who can adequately access healthcare appointments, medications, and other treatments, the combination of driving restrictions and sparse or nonexistent public transportation options interferes with daily living and their overall quality of life.

Latest

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Short-term administration of carbapenem antibiotics may be beneficial in the treatment of VPA overdose in patients with no history of seizure disorder.

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

The primary efficacy outcome was achieved in a higher percentage of patients in the exposure range of 9 to 15 ng/mL compared with patients in the 3 to 7 ng/mL and >7 to 9 ng/mL ranges.

Women With Epilepsy More Likely to Have Major Depressive Disorder

Women With Epilepsy More Likely to Have Major Depressive Disorder

Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.

Fycompa Granted Priority Review for Pediatric Indications

Fycompa Granted Priority Review for Pediatric Indications

The sNDA included data from Study 311 (N=180), an ongoing, open-label, multicenter trial with an extension phase that evaluated the safety, tolerability, and exposure-efficacy relationship of Fycompa oral suspension as adjunctive therapy in children (4 to 11 years) with inadequately controlled POS or PGTC seizures.

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

The results of this study should help reassure and encourage women with epilepsy without a prior diagnosis of infertility or an associated disorder who are seeking pregnancy.

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

The effects of short-term VPA exposure on placental compound carrier expression were examined in this study.

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

A majority of participants (67%) had reported seeing a neurologist or epilepsy specialist in the past year, with younger adults comprising a higher percentage of these participants.

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

The expanded approval was supported by extrapolated efficacy data from placebo-controlled studies in adults with partial-onset seizures.

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

The prevalence of major congenital malformations in offspring who are prenatally exposed to antiepileptic drugs is highest among those exposed to carbamazepine, phenobarbital doses of >80 mg/day, valproate of ≤650 mg/day, and levetiracetam at 250 to 4000 mg/day.

Sign Up for Free e-newsletters



CME Focus