Epilepsy

Psychotherapy May Reduce Frequency of Nonepileptic Seizures

Psychotherapy May Reduce Frequency of Nonepileptic Seizures

Adherence to psychotherapy is associated with improved outcomes in individuals with psychogenic nonepileptic seizures.

Seizure Monitoring Smartwatch Cleared for Use in Children

Seizure Monitoring Smartwatch Cleared for Use in Children

By

The Food and Drug Administration has granted 501(k) clearance to the Embrace watch for use in epilepsy patients aged ≥6 years. The smartwatch identifies generalized tonic-clonic seizures and alerts caregivers.

Researchers ID Factors Predictive of Naming Decline After Epilepsy Surgery

Researchers ID Factors Predictive of Naming Decline After Epilepsy Surgery

By

The use of externally validated nomograms in 2 easy-to-use formats can help physicians assess the probability of naming decline in patients considering epilepsy surgery for treatment of pharmacoresistant temporal lobe epilepsy.

CBD Superior to Placebo, Similar to AEDs for Managing Epilepsy Syndromes

CBD Superior to Placebo, Similar to AEDs for Managing Epilepsy Syndromes

By

Cannabinoids appeared more effective than placebo and similarly efficacious as other antiepileptic drugs for managing pediatric patients with Dravet syndrome and Lennox-Gastaut syndrome as well as adults with epilepsy.

Prenatal Valproate Exposure Linked to Increased ADHD Risk

Prenatal Valproate Exposure Linked to Increased ADHD Risk

Use of the antiepileptic drug (AED) valproate during pregnancy is associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD) among offspring.

Postresection Monitoring May Provide Further Insights on Epileptogenic Zone Following Multistage Epilepsy Surgery

Postresection Monitoring May Provide Further Insights on Epileptogenic Zone Following Multistage Epilepsy Surgery

By

Investigators found that it may be prudent to continue postoperative invasive monitoring in children who have had surgical resection of epileptic lesions.

Aggressive, Prolonged Treatment for Refractory Status Epilepticus May Be Justified With Good Neurologic Prognosis

Aggressive, Prolonged Treatment for Refractory Status Epilepticus May Be Justified With Good Neurologic Prognosis

By

Aggressive and prolonged treatment of refractory status epilepticus may be justified in patients with cardiac arrest with favorable multimodal prognostic indicators.

Multivariable Clinical Trait Model Predicts Childhood Epilepsy Risk

Multivariable Clinical Trait Model Predicts Childhood Epilepsy Risk

By

Researchers sought to develop a prediction model that determines the risk for childhood epilepsy and included clinical characteristic variables such as sex, medical history, age of first seizure, and event description, along with electroencephalogram readings.

Heart Rate, Movement Detect Nocturnal Seizures in Epilepsy

Heart Rate, Movement Detect Nocturnal Seizures in Epilepsy

By

Investigators examined whether a bracelet capable of measuring heart rate and movement would be beneficial for detecting nocturnal seizures in patients with epilepsy.

Nocturnal Seizures With Convulsions Linked to SUDEP

Nocturnal Seizures With Convulsions Linked to SUDEP

By

Investigators sought to predict the incidence of SUDEP in people with intellectual disabilities in residential care settings and to determine its relationship with nocturnal seizures and nocturnal supervision.

Acetaminophen Is Safe, May Be Effective to Reduce Febrile Seizure Recurrence

Acetaminophen Is Safe, May Be Effective to Reduce Febrile Seizure Recurrence

By

Investigators sought to determine whether rectal acetaminophen reduces rates of second febrile seizure in children during the same febrile illness when given rectally shortly after initial seizure.

Strategies for Reducing Cognitive Deficits in Pediatric Epilepsy

Strategies for Reducing Cognitive Deficits in Pediatric Epilepsy

By

In the past, many epilepsy providers have focused solely on seizure control as a way to improve developmental outcomes and HRQOL; however, we now know that the most effective treatment for pediatric epilepsy is comprehensive.

Oxtellar XR Gains Monotherapy Indication for Partial-Onset Seizures

Oxtellar XR Gains Monotherapy Indication for Partial-Onset Seizures

By

The FDA has approved the supplemental New Drug Application for Oxtellar XR to include monotherapy use for the treatment of partial-onset seizures patients aged ≥6 years.

Volume Perfusion CT Helps Differentiate Ictal Stroke Mimics, but Not Postictal, From Acute Ischemic Stroke

Volume Perfusion CT Helps Differentiate Ictal Stroke Mimics, but Not Postictal, From Acute Ischemic Stroke

By

Patients were initially misjudged to have presented with an acute stroke instead of an epileptic seizure.

Unplanned Pregnancy in Women With Epilepsy Increases Risk for Spontaneous Fetal Loss

Unplanned Pregnancy in Women With Epilepsy Increases Risk for Spontaneous Fetal Loss

By

Investigators assessed the effect of unplanned vs planned pregnancies in this patient population on the risk for SFL.

Epilepsy, Sleep Apnea, and SUDEP: A Closer Look

Epilepsy, Sleep Apnea, and SUDEP: A Closer Look

By

The comorbid presence of central apnea has been identified by multiple researchers as predictive of SUDEP.

Study Identifies Early-Onset Motor Behaviors in DES-Triggered Seizures

Study Identifies Early-Onset Motor Behaviors in DES-Triggered Seizures

By

Investigators evaluated seizure stimulation parameters, electroclinical data, semiology, and anatomical localization in spontaneous and stimulated seizures.

<i>NBEA</i> Gene Associated With Neurodevelopmental Delay, Childhood Epilepsy

NBEA Gene Associated With Neurodevelopmental Delay, Childhood Epilepsy

By

Investigators analyzed the NBEA gene to determine whether or not it could be a biomarker for early childhood epilepsy.

Myoclonic-Atonic Seizures and Lennox-Gastaut Syndrome Present With Overlapping Features, Difficulty in Diagnosis

Myoclonic-Atonic Seizures and Lennox-Gastaut Syndrome Present With Overlapping Features, Difficulty in Diagnosis

By

Patients with a higher number of Lennox-Gastaut syndrome traits had a greater likelihood of ongoing seizures, and each additionally observed Lennox-Gastaut syndrome trait was associated with half the likelihood of achieving seizure freedom.

SISCOM Hyperperfusion Identifies Epilepsy Lateralization

SISCOM Hyperperfusion Identifies Epilepsy Lateralization

By

Compared with nonmotor seizures, there was a significant difference with basal ganglia and thalamus coactivation in terms of seizures with elementary motor signs and automatisms.

Lorcaserin May Reduce Motor Seizures in Pediatric Treatment-Resistant Epilepsy

Lorcaserin May Reduce Motor Seizures in Pediatric Treatment-Resistant Epilepsy

By

Lorcaserin may reduce seizure frequency in patients with Dravet syndrome and severe childhood-onset epilepsies.

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

By

The study utilized the Vaccine Safety Datalink and included children who received the first dose of a measles-containing vaccine between 12 and 23 months old during the study period of January 1, 2003 to September 20, 2015.

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

By

Investigators assessed the frequency of bilateral independent periodic discharges in patients experiencing electrographic seizures and their effect on patient mortality and clinical outcomes.

Eslicarbazepine Acetate Well Tolerated, Effective in Post-Stroke Epilepsy

Eslicarbazepine Acetate Well Tolerated, Effective in Post-Stroke Epilepsy

By

Eslicarbazepine acetate is well tolerated and may be effective for treating patients with post-stroke epilepsy.

Long-Term Effectiveness of Adjunctive Brivaracetam For Previously Treated Focal Seizures

Long-Term Effectiveness of Adjunctive Brivaracetam For Previously Treated Focal Seizures

By

Adjunctive brivaracetam may provide long term effectiveness in adults who have not seen optimal results with other common treatments.

Generic Lamotrigine, Levetiracetam Formulations Comparable to Brand Name AEDs

Generic Lamotrigine, Levetiracetam Formulations Comparable to Brand Name AEDs

By

Bioequivalent generic formulations of 2 antiepileptic medications were comparable to brand name treatments for new-onset epilepsy.

Psychiatric Adverse Effects from Levetiracetam Linked to Certain Factors

Psychiatric Adverse Effects from Levetiracetam Linked to Certain Factors

By

Researchers aimed to identify risk factors associated with a psychiatric event following a first prescription for levetiracetam.

Fenfluramine Improves Emotion and Behavior Regulation in Pediatric Dravet Syndrome

Fenfluramine Improves Emotion and Behavior Regulation in Pediatric Dravet Syndrome

By

Children with Dravet syndrome receiving fenfluramine experienced improvements in emotional regulation, behavioral regulation, and planning and organization abilities.

SSRIs, TCAs, Antipsychotics Decrease Seizure Frequency in the Epilepsy Monitoring Unit

SSRIs, TCAs, Antipsychotics Decrease Seizure Frequency in the Epilepsy Monitoring Unit

By

Patients taking an active treatment regimen consisting of SSRIs, TCAs, or antipsychotic medications are less likely to experience a seizure in the epilepsy monitoring unit.

Does the Ketogenic Diet Prevent Relapse in Infantile Spasms?

Does the Ketogenic Diet Prevent Relapse in Infantile Spasms?

By

The classic ketogenic diet may not have a significant impact on preventing shttp://cms.haymarketmedia.com/Images/find.gifeizure occurrence in patients with infantile spasms of unknown etiology.

Sign Up for Free e-newsletters



CME Focus