Epilepsy

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

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Cannabidiol may be effective as add-on treatment for drop seizures associated with Lennox-Gastaut syndrome.

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

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The FDA has approved Afinitor Disperz for the adjunctive treatment of patients aged ≥2 years with TSC-associated partial-onset seizures.

Increased Risk of Unnatural Death in People With Epilepsy

Increased Risk of Unnatural Death in People With Epilepsy

The risk of unnatural death is increased among people with epilepsy.

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

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Because of the small size of the study sample, the findings may be limited to this patient population and may be hard to generalize across all pediatric patients with Dravet syndrome.

EEG Changes in Pediatric BECTS Promoted by Treatment With Levetiracetam, Sulthiame

EEG Changes in Pediatric BECTS Promoted by Treatment With Levetiracetam, Sulthiame

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The small sample size included in the study precludes the ability to make generalized statements about electroencephalogram pattern characteristics in the entire pediatric patient population with BECTS.

Early-Life Epilepsy Should Be Urgently Treated With EBM

Early-Life Epilepsy Should Be Urgently Treated With EBM

Best diagnostics and evidence-based treatments should be used from the start of the disease.

Educational Attainment Down With In Utero Exposure to AEDs

Educational Attainment Down With In Utero Exposure to AEDs

Exposure to sodium valproate or a combination of antiepileptic drugs in utero is associated with worse attainment on national educational tests.

Fycompa sNDA Submitted for Pediatric Seizure Indications

Fycompa sNDA Submitted for Pediatric Seizure Indications

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The proposed pediatric indications are based on a 2018 Draft Guidance that supports extrapolating efficacy data of approved drugs to treat POS in adults to pediatric patients aged ≥4 years.

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

Code Stroke System Reduces Post-Stroke Epilepsy Risk in Older Adults

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The adjusted analysis also demonstrated that the code stroke system was associated with a decreased risk for post-stroke epilepsy within 5 years of stroke.

Epilepsy Associated With Greater Risk for Serious Transportation Accidents

Epilepsy Associated With Greater Risk for Serious Transportation Accidents

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The registers used in this study did not collect information on whether individuals with epilepsy were actually responsible for the transportation accidents.

A Convenient Truth: The Problem With Seizure Under-Reporting and How to Fix It

A Convenient Truth: The Problem With Seizure Under-Reporting and How to Fix It

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Before we begin to rely more heavily on technology for seizure detection, clinician-patient trust needs to improve.

Cannabinoids May Be Effective as Adjunctive Treatment for Refractory Epilepsy

Cannabinoids May Be Effective as Adjunctive Treatment for Refractory Epilepsy

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Pharmaceutical-grade CBD used as adjunctive therapy in patients with pediatric-onset drug-resistant epilepsy may reduce the frequency of seizures.

Older Epilepsy Patients More Likely to Experience AED, Non-AED Drug Interaction

Older Epilepsy Patients More Likely to Experience AED, Non-AED Drug Interaction

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The findings are limited to the 50 most-prescribed non-epilepsy drugs assessed in this Medicare population and may not generalize to non-Medicare beneficiaries who receive other non-epilepsy drugs.

More Evidence Supports Benefits of Cannabidiol for Treatment-Resistant Epilepsy

More Evidence Supports Benefits of Cannabidiol for Treatment-Resistant Epilepsy

Cannabinoids are effective as an adjunctive treatment for reducing seizure frequency in pediatric-onset treatment-resistant epilepsy.

Predicting Seizure Risk Following Ischemic Stroke With SeLECT Score

Predicting Seizure Risk Following Ischemic Stroke With SeLECT Score

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Investigators sought to validate a tool to identify post-stroke seizure risk.

Behavioral Interventions May Have Some Benefit in Refractory Epilepsy

Behavioral Interventions May Have Some Benefit in Refractory Epilepsy

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Participants in the progressive muscle relaxation group reported greater reductions in stress vs those randomized to the focused-attention activity.

Vitamin D Supplement May Benefit Bone Health in Epilepsy

Vitamin D Supplement May Benefit Bone Health in Epilepsy

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Five studies demonstrated a significant improvement in serum 25-hydroxyvitamin D from baseline to post-treatment vitamin D supplementation in patients with epilepsy.

Levetiracetam Associated With Less Monotherapy Failure in Infantile Seizures

Levetiracetam Associated With Less Monotherapy Failure in Infantile Seizures

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The study findings are particularly relevant given the current mismatch between clinical practice and regulatory approval of levetiracetam in infantile seizures.

Consensus Statement: Defining Pediatric Status Epilepticus Syndromes

Consensus Statement: Defining Pediatric Status Epilepticus Syndromes

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The investigators hope that the consensus statement helps resolve several clinical questions in cases of pediatric new onset status epilepticus syndromes.

Exposure to Valproate During Pregnancy May Have Effect on Offspring's School Performance

Exposure to Valproate During Pregnancy May Have Effect on Offspring's School Performance

School performance is lower in children with prenatal exposure to valproate.

Seizure Frequency May Lessen With Stress Reduction

Seizure Frequency May Lessen With Stress Reduction

Participants recorded daily mood and stress ratings plus seizure counts using an electronic diary and medication adjustments were not allowed.

Influenza vaccine not associated with increased risk of epilepsy in children

No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway.

Chronic Traumatic Encephalopathy Uncommon in Treatment-Refractory Epilepsy

Chronic Traumatic Encephalopathy Uncommon in Treatment-Refractory Epilepsy

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While epilepsy-related head trauma was common, 9 of 10 patients displayed no evidence of CTE.

FDA Approves Smart Watch for Epilepsy Management

FDA Approves Smart Watch for Epilepsy Management

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The FDA has cleared the Embrace smart watch for managing epilepsy.

Cannabidiol Reduces Drop Seizures in Lennox-Gastaut Syndrome

Cannabidiol Reduces Drop Seizures in Lennox-Gastaut Syndrome

Add-on cannabidiol is associated with reduced monthy drop seizure frequency in patients with Lennox-Gastaut sydrome associated drop seizures.

Focal Epilepsy Linked to Increased Risk for Mood Disorders

Focal Epilepsy Linked to Increased Risk for Mood Disorders

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Clinicians should evaluate their patients, especially patients with focal epilepsy, for mood disorders.

High Doses of Topiramate for Epilepsy in Pregnancy Increase Risks for Oral Clefts in Offspring

High Doses of Topiramate for Epilepsy in Pregnancy Increase Risks for Oral Clefts in Offspring

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Women receiving topiramate for epilepsy were exposed to high cumulative doses, increasing the risk for oral clefts in offspring.

Seizure Control Diminishes With Subsequent Antiepileptic Drug Therapy

Seizure Control Diminishes With Subsequent Antiepileptic Drug Therapy

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Patients with tough-to-treat seizures may require nonpharmacologic treatment such as resective surgery.

More Than One-Third of New Cases of Epilepsy Are Treatment Refractory

More Than One-Third of New Cases of Epilepsy Are Treatment Refractory

Over one-third of patients with newly diagnosed epilepsy do not respond to antiepileptic drug treatment.

Treating Levetiracetam-Induced Behavioral Effects With Vitamin B6

Treating Levetiracetam-Induced Behavioral Effects With Vitamin B6

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Vitamin B6 was found to effectively treat the behavioral adverse effects seen with levetiracetam.

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