Epilepsy

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

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Short-term administration of carbapenem antibiotics may be beneficial in the treatment of VPA overdose in patients with no history of seizure disorder.

Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

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In individuals who can adequately access healthcare appointments, medications, and other treatments, the combination of driving restrictions and sparse or nonexistent public transportation options interferes with daily living and their overall quality of life.

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

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Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

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The primary efficacy outcome was achieved in a higher percentage of patients in the exposure range of 9 to 15 ng/mL compared with patients in the 3 to 7 ng/mL and >7 to 9 ng/mL ranges.

Women With Epilepsy More Likely to Have Major Depressive Disorder

Women With Epilepsy More Likely to Have Major Depressive Disorder

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Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.

Fycompa Granted Priority Review for Pediatric Indications

Fycompa Granted Priority Review for Pediatric Indications

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The sNDA included data from Study 311 (N=180), an ongoing, open-label, multicenter trial with an extension phase that evaluated the safety, tolerability, and exposure-efficacy relationship of Fycompa oral suspension as adjunctive therapy in children (4 to 11 years) with inadequately controlled POS or PGTC seizures.

Stroke Survivors Have Higher Risk for Subsequent Seizures Than General Population

Stroke Survivors Have Higher Risk for Subsequent Seizures Than General Population

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At 8 years, the cumulative rate of any hospitalization or emergency department visit for seizure was higher among patients with stroke vs the general population.

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

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The results of this study should help reassure and encourage women with epilepsy without a prior diagnosis of infertility or an associated disorder who are seeking pregnancy.

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

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The effects of short-term VPA exposure on placental compound carrier expression were examined in this study.

Cannabidiol plus conventional antiepileptics reduces drop seizure frequency in the Lennox-Gastaut syndrome

Amongst adults and children with the Lennox-Gastaut syndrome, addition of cannabidiol to a conventional antiepileptic regimen reduced drop seizure frequency compared to placebo treated patients.

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

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A majority of participants (67%) had reported seeing a neurologist or epilepsy specialist in the past year, with younger adults comprising a higher percentage of these participants.

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

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The expanded approval was supported by extrapolated efficacy data from placebo-controlled studies in adults with partial-onset seizures.

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

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The prevalence of major congenital malformations in offspring who are prenatally exposed to antiepileptic drugs is highest among those exposed to carbamazepine, phenobarbital doses of >80 mg/day, valproate of ≤650 mg/day, and levetiracetam at 250 to 4000 mg/day.

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

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The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

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The approval was based on a 12-week, double-blind, placebo-controlled study (N=295) in pediatric patients 4-17 years of age.

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

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The approval is specifically for bilateral anterior thalamic nucleus stimulation and is based on results from the SANTE study (Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy).

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Although most adults with epilepsy report taking epilepsy medication, less than half of those report having their seizures controlled.

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

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Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

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Researchers evaluated the use of genetic screening to identify individuals who are at risk for carbamazepine-induced cutaneous adverse drug reactions.

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

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Investigators conducted a population-based study to assess risk and cause of unnatural mortality in individuals with epilepsy.

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

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Clinicians should conduct a medical evaluation as soon as suspicious symptoms are reported and discontinue lamotrigine if HLH is suspected.

Treatment-Emergent Adverse Events With Adjunctive Eslicarbazepine Acetate in Pediatric Epilepsy

Treatment-Emergent Adverse Events With Adjunctive Eslicarbazepine Acetate in Pediatric Epilepsy

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Researchers evaluated the incidence of treatment-emergent adverse events in pediatric patients taking eslicarbazepine acetate with other antiepileptic drugs to better understand tolerability profiles.

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

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Researchers conducted post-hoc analysis of data derived from 2 randomized, placebo-controlled trials to determine the safety and tolerability of eslicarbazepine in pediatric patients with partial-onset seizures not responsive to treatment with ≤2 antiepileptic drugs.

Seizure-Free Status Prior to Conception Lowers Odds of Recurrence During Pregnancy

Seizure-Free Status Prior to Conception Lowers Odds of Recurrence During Pregnancy

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Prior studies have suggested that women with epilepsy who are seizure free ≥9 months prior to pregnancy have a high likelihood of remaining seizure free during pregnancy.

Listening to Sonified EEG Fluctuations May Help Identify Silent Seizures

Listening to Sonified EEG Fluctuations May Help Identify Silent Seizures

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In the event where electroencephalograms featured either seizures or seizure-like patterns, nonexpert medical students who auditorily reviewed the electroencephalograms rated samples as seizures with a higher degree of specificity vs experts or nonexpert medical students.

Serotonin Reuptake Inhibitors May Improve OSA in Depression With and Without Epilepsy

Serotonin Reuptake Inhibitors May Improve OSA in Depression With and Without Epilepsy

Research was conducted to identify an association between the use of serotonin reuptake inhibitors and obstructive sleep apnea in a population of individuals with depression with or without epilepsy.

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

Add-On Cannabidiol for Treatment-Resistant Drop Seizures in Lennox-Gastaut Syndrome

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Cannabidiol may be effective as add-on treatment for drop seizures associated with Lennox-Gastaut syndrome.

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

Afinitor Disperz Approved to Treat TSC-Associated Partial-Onset Seizures

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The FDA has approved Afinitor Disperz for the adjunctive treatment of patients aged ≥2 years with TSC-associated partial-onset seizures.

Increased Risk of Unnatural Death in People With Epilepsy

Increased Risk of Unnatural Death in People With Epilepsy

The risk of unnatural death is increased among people with epilepsy.

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

Cannabidiol Safe, Well Tolerated in Children With Dravet Syndrome

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Because of the small size of the study sample, the findings may be limited to this patient population and may be hard to generalize across all pediatric patients with Dravet syndrome.

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