Epilepsy
Unintended Pregnancy Common in Women With Epilepsy
October 17, 2018It is likely that both maternal age and socioeconomic status contribute to the higher rates of pregnancy in WWE compared with women without epilepsy.
Managing Status Epilepticus in Palliative Care: Accounting for Patient and Family Experience
October 15, 2018There are considerations for treating these seizures as part of the overall goals of palliative care, which include the family's experience.
Fycompa Approved for Younger Epilepsy Patients With Partial-Onset Seizures
October 03, 2018Safety data for Fycompa was consistent with the safety profile in adult populations without the need for weight-based dosing.
DEA Reschedules Marijuana-Based Drug Epidiolex
October 01, 2018Drugs with a Schedule V classification have proven medical use and low abuse potential.
NDA Submitted for Valtoco Nasal Spray to Treat Acute Repetitive Seizures
October 01, 2018The Company states that the NDA is supported by robust clinical trial data, including patients studies where more than 1600 seizures were treated with Valtoco nasal spray.
Folic Acid Supplementation May Protect Against Language Delay in AED-Exposed Children
September 24, 2018The odds of language delay were lower at 18 months and 36 months in children exposed to AEDs in utero whose mothers took folic acid.
Significant Variations in Epilepsy Surgical Strategy, Deficit Reporting Exist
September 20, 2018This widespread variation in strategies may contribute to undesirable outcomes that are characterized by poor seizure control and added deficits.
Brivaracetam Effective for Reducing Seizures in Patients with Epileptic Encephalopathies
September 18, 2018Although 2 patients experienced an increase in seizure frequency, the remaining patients did not experience a change in frequency.
Add-On Cannabidiol Reduces Seizure Frequency in Treatment-Refractory Epilepsy
September 14, 2018Countable seizure types were recorded in parents' and caregivers' clinical diaries during a 4-week baseline period.
Clinical Factors Influencing Neuroimaging Yield in Nonindex Seizures Identified
September 14, 2018The investigators sought to detect whether neuroimaging during an emergency department visit was associated with acute changes in the management of patients.
Late-Onset Epilepsy Linked to APOE ε4, Smoking, Diabetes
September 13, 2018The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.
Outcomes After Seizure Recurrence Upon AED Withdrawal Following Temporal Lobectomy
September 10, 2018Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.
Sympazan Oral Film Granted Tentative Approval for Lennox-Gastaut Syndrome
September 07, 2018Clobazam is currently available as oral tablets and suspension under the trade name Onfi (Lundbeck).
Everolimus, Sirolimus Generally Safe for Epilepsy in Tuberous Sclerosis Complex
September 05, 2018Approximately 78% of treated patients experienced at least 1 treatment-related adverse event.
Anticonvulsants Not Associated With Risk for Perinatal Bleeding
August 27, 2018The findings offer some reassurance for clinicians and for pregnant women who are successfully treated with enzyme-inducing ACDs.
Diacomit Approved for the Treatment of Dravet Sydrome
August 23, 2018Diacomit was evaluated in 2 multicenter, placebo-controlled, double-blind, randomized studies.
Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy
August 16, 2018The results of this review are applicable primarily to persons with focal onset seizures, with 88% of included participants experiencing this type of seizure at baseline.
High Anxiety Symptoms Prevalent in Epilepsy, Mesial Temporal Sclerosis
August 15, 2018Investigators assessed demographic and epilepsy-specific factors independently associated with anxiety, including lesions and seizure focus localization.
Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines
August 14, 2018An expert subcommittee was formed consisting of members of the AAN and AES to update the 2004 evidence-based guidelines on epilepsy treatment with AEDs.
Vagus Nerve Stimulation in Pediatric Epilepsy: Weighing the Risks and Benefits
August 10, 2018Studies that have evaluated the use of VNS in children, including those as young as 6 months old, and have generally concluded that it is well tolerated and improves quality of life.
Viral vector based gene therapies show promise for treating focal epilepsy [PreClinical]
August 09, 2018Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons.
New Formulation of Status Epilepticus Treatment To Be Reviewed
August 06, 2018The NDA for IM/IV Captisol-Enabled Fosphenytoin has been accepted for review and given a Prescription Drug Fee User Act date, by the FDA.
Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy
August 03, 2018Potentially modifiable risk factors in midlife are associated with the risk of developing late-onset epilepsy.
Addressing Psychiatric Comorbidities in Pediatric Epilepsy: Expert Opinions
August 01, 2018Cognitive and linguistic deficits have been cited as risk factors for psychiatric comorbidity in pediatric epilepsy, along with family factors such as parenting style and quality of the parent-child relationship.
Disease-Specific ICD Code Helps Identify Infantile Spasms in Claims Data
July 23, 2018Claims data spanning 4 years were obtained from a pediatric accountable care organization.
Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed
July 20, 2018The safety and efficacy of clobazam monotherapy in patients with new-onset focal or generalized seizures was investigated in a new Cochrane systematic review.
Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus
July 20, 2018The efficacy was reported to be significantly higher in patients who had taken benzodiazepines.
Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths
July 19, 2018Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.
Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms
July 19, 2018The FDA has approved an abbreviated New Drug Application for Vigadrone, the generic alternative to Sabril powder for oral solution.
Significant Changes in Serotonin Levels Observed Following Epileptic Seizures
July 10, 2018Investigators sought to examine whether seizures are capable of causing changes in serotonin levels in the peripheral circulation.
Neurology Advisor Articles
- Erenumab Superior to Placebo for Reducing Migraine Disability, Improving HRQoL
- Managing Status Epilepticus in Palliative Care: Accounting for Patient and Family Experience
- Congress Passes Bill to Fight Opioid Crisis
- Physical Activity Decreases Vascular Comorbidities in Multiple Sclerosis
- Review of Factors Impacting Sport-Related Concussion Headaches
- Anodal tDCS Offers Possible Benefit for Improving Item Recall in Post-Stroke Aphasia
- Hospitalization Tied to Brain Abnormalities in Older Adults
- Spending Often Persists in High-Cost Medicare-Medicaid Eligible
- Skills-Based Intervention Did Not Cut Systolic BP After Stroke, TIA
- High Frequency of Headaches Following Dialysis Associated With BUN and Blood Pressure