Epilepsy

Study Identifies Early-Onset Motor Behaviors in DES-Triggered Seizures

Study Identifies Early-Onset Motor Behaviors in DES-Triggered Seizures

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Investigators evaluated seizure stimulation parameters, electroclinical data, semiology, and anatomical localization in spontaneous and stimulated seizures.

<i>NBEA</i> Gene Associated With Neurodevelopmental Delay, Childhood Epilepsy

NBEA Gene Associated With Neurodevelopmental Delay, Childhood Epilepsy

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Investigators analyzed the NBEA gene to determine whether or not it could be a biomarker for early childhood epilepsy.

Myoclonic-Atonic Seizures and Lennox-Gastaut Syndrome Present With Overlapping Features, Difficulty in Diagnosis

Myoclonic-Atonic Seizures and Lennox-Gastaut Syndrome Present With Overlapping Features, Difficulty in Diagnosis

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Patients with a higher number of Lennox-Gastaut syndrome traits had a greater likelihood of ongoing seizures, and each additionally observed Lennox-Gastaut syndrome trait was associated with half the likelihood of achieving seizure freedom.

SISCOM Hyperperfusion Identifies Epilepsy Lateralization

SISCOM Hyperperfusion Identifies Epilepsy Lateralization

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Compared with nonmotor seizures, there was a significant difference with basal ganglia and thalamus coactivation in terms of seizures with elementary motor signs and automatisms.

Lorcaserin May Reduce Motor Seizures in Pediatric Treatment-Resistant Epilepsy

Lorcaserin May Reduce Motor Seizures in Pediatric Treatment-Resistant Epilepsy

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Lorcaserin may reduce seizure frequency in patients with Dravet syndrome and severe childhood-onset epilepsies.

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

Does Gestational Age at Birth Affect Seizure Risk After Measles Vaccine Administration?

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The study utilized the Vaccine Safety Datalink and included children who received the first dose of a measles-containing vaccine between 12 and 23 months old during the study period of January 1, 2003 to September 20, 2015.

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

Bilateral Independent Periodic Discharges and Poor Seizure Outcomes

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Investigators assessed the frequency of bilateral independent periodic discharges in patients experiencing electrographic seizures and their effect on patient mortality and clinical outcomes.

Eslicarbazepine Acetate Well Tolerated, Effective in Post-Stroke Epilepsy

Eslicarbazepine Acetate Well Tolerated, Effective in Post-Stroke Epilepsy

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Eslicarbazepine acetate is well tolerated and may be effective for treating patients with post-stroke epilepsy.

Long-Term Effectiveness of Adjunctive Brivaracetam For Previously Treated Focal Seizures

Long-Term Effectiveness of Adjunctive Brivaracetam For Previously Treated Focal Seizures

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Adjunctive brivaracetam may provide long term effectiveness in adults who have not seen optimal results with other common treatments.

Generic Lamotrigine, Levetiracetam Formulations Comparable to Brand Name AEDs

Generic Lamotrigine, Levetiracetam Formulations Comparable to Brand Name AEDs

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Bioequivalent generic formulations of 2 antiepileptic medications were comparable to brand name treatments for new-onset epilepsy.

Psychiatric Adverse Effects from Levetiracetam Linked to Certain Factors

Psychiatric Adverse Effects from Levetiracetam Linked to Certain Factors

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Researchers aimed to identify risk factors associated with a psychiatric event following a first prescription for levetiracetam.

Fenfluramine Improves Emotion and Behavior Regulation in Pediatric Dravet Syndrome

Fenfluramine Improves Emotion and Behavior Regulation in Pediatric Dravet Syndrome

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Children with Dravet syndrome receiving fenfluramine experienced improvements in emotional regulation, behavioral regulation, and planning and organization abilities.

SSRIs, TCAs, Antipsychotics Decrease Seizure Frequency in the Epilepsy Monitoring Unit

SSRIs, TCAs, Antipsychotics Decrease Seizure Frequency in the Epilepsy Monitoring Unit

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Patients taking an active treatment regimen consisting of SSRIs, TCAs, or antipsychotic medications are less likely to experience a seizure in the epilepsy monitoring unit.

Does the Ketogenic Diet Prevent Relapse in Infantile Spasms?

Does the Ketogenic Diet Prevent Relapse in Infantile Spasms?

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The classic ketogenic diet may not have a significant impact on preventing shttp://cms.haymarketmedia.com/Images/find.gifeizure occurrence in patients with infantile spasms of unknown etiology.

Eslicarbazepine Acetate Dose and ADRs Across Weight Groups Examined

Eslicarbazepine Acetate Dose and ADRs Across Weight Groups Examined

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Individual treatment-emergent adverse events (TEAE) did not increase with higher modal daily dose of eslicarbazepine acetate in pediatric patients with focal seizures.

Positive Retention Rates and Sustained Efficacy With Perampanel in Epilepsy

Positive Retention Rates and Sustained Efficacy With Perampanel in Epilepsy

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Perampanel at a median maximum dose of 6 mg (1 to 20 mg) is associated with good long-term treatment retention and sustained efficacy.

Enzyme-Inducing Antiepileptic Drugs Increase Vitamin D Requirements in Epilepsy

Enzyme-Inducing Antiepileptic Drugs Increase Vitamin D Requirements in Epilepsy

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Investigators aimed to determine whether utilization of enzyme-inducing antiepileptic drugs increases vitamin D requirements.

Does Total Benzodiazepine Dose Affect Pediatric ICU Duration for Status Epilepticus?

Does Total Benzodiazepine Dose Affect Pediatric ICU Duration for Status Epilepticus?

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Low total benzodiazepine dosing is linked to longer intensive care unit stays and seizure duration in children.

Transdermal Cannabidiol Gel Well-Tolerated in Adults With Focal Epilepsy

Transdermal Cannabidiol Gel Well-Tolerated in Adults With Focal Epilepsy

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An investigational transdermal cannabidiol gel was well-tolerated and consistently effective for adults with focal epilepsy.

Risk of Sudden Unexplained Death in Epilepsy May Wane Over Time

Risk of Sudden Unexplained Death in Epilepsy May Wane Over Time

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Patients at high risk for SUDEP may shift to a lower risk group over time.

Tolerance to Cannabidiol for Treatment-Resistant Epilepsy Seen Over Time

Tolerance to Cannabidiol for Treatment-Resistant Epilepsy Seen Over Time

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Tolerance to cannabidiol may exist, potentially limiting its efficacy as an antiseizure therapy in the long-term management of epilepsy.

Migraine Comorbidity May Increase Depression Risk in Patients With Focal Epilepsy

Migraine Comorbidity May Increase Depression Risk in Patients With Focal Epilepsy

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Patients with focal epilepsy and comorbid migraine may have greater depressive symptoms compared with individuals without the comorbidity.

DRESS May Be Mitigated by Slower Titration Rates of Cenobamate

DRESS May Be Mitigated by Slower Titration Rates of Cenobamate

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Investigators examined whether a reduction in titration rates utilized in earlier trials would reduce the incidence of DRESS in patients taking cenobamate.

Efficacy, Safety of Eslicarbazepine Acetate in Elderly Patients Examined

Efficacy, Safety of Eslicarbazepine Acetate in Elderly Patients Examined

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Safety and efficacy were examined in adults aged 60 compared with adults younger than 60.

Adverse Reactions Increase Risk for Further Drug Intolerability in Epilepsy

Adverse Reactions Increase Risk for Further Drug Intolerability in Epilepsy

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Antiepileptic drugs are more likely to be tolerated by patients who have not experienced adverse drug reactions to previous antiepileptic drugs.

Behavioral Health Screening Advocated for Teens With Epilepsy

Behavioral Health Screening Advocated for Teens With Epilepsy

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Teen patients with epilepsy experience high levels of depressive symptoms, with 13% requiring behavioral health interventions.

Should Antiepileptic Serum Concentrations Be Monitored More Frequently in Pregnancy?

Should Antiepileptic Serum Concentrations Be Monitored More Frequently in Pregnancy?

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Investigators observed that in pregnant women with epilepsy, the body begins to rapidly metabolize lamotrigine and levetiracetam at week 16 causing a fluctuating pattern of serum drug concentration.

Long-Term Safety of Midazolam Nasal Spray for Acute Repetitive Seizures

Long-Term Safety of Midazolam Nasal Spray for Acute Repetitive Seizures

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Midazolam nasal spray, a novel benzodiazepine formulation, may be a safe, long-term treatment option for acute seizure episodes.

Early Genetic Testing May Benefit Patients With Infantile-Onset Epilepsies

Early Genetic Testing May Benefit Patients With Infantile-Onset Epilepsies

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Individuals with epilepsy who receive an early genetic diagnosis may benefit from more precise medical treatment and accurate counseling.

Perampanel Add-On Therapy Effectively Treats Focal and Generalized Epilepsy

Perampanel Add-On Therapy Effectively Treats Focal and Generalized Epilepsy

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In the retrospective study, the primary reason for initiating perampanel was poor seizure control.

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