Epilepsy
Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy
August 16, 2018The results of this review are applicable primarily to persons with focal onset seizures, with 88% of included participants experiencing this type of seizure at baseline.
High Anxiety Symptoms Prevalent in Epilepsy, Mesial Temporal Sclerosis
August 15, 2018Investigators assessed demographic and epilepsy-specific factors independently associated with anxiety, including lesions and seizure focus localization.
Treatment of New-Onset Epilepsy: AAN, AES Update Practice Guidelines
August 14, 2018An expert subcommittee was formed consisting of members of the AAN and AES to update the 2004 evidence-based guidelines on epilepsy treatment with AEDs.
Vagus Nerve Stimulation in Pediatric Epilepsy: Weighing the Risks and Benefits
August 10, 2018Studies that have evaluated the use of VNS in children, including those as young as 6 months old, and have generally concluded that it is well tolerated and improves quality of life.
New Formulation of Status Epilepticus Treatment To Be Reviewed
August 06, 2018The NDA for IM/IV Captisol-Enabled Fosphenytoin has been accepted for review and given a Prescription Drug Fee User Act date, by the FDA.
Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy
August 03, 2018Potentially modifiable risk factors in midlife are associated with the risk of developing late-onset epilepsy.
Addressing Psychiatric Comorbidities in Pediatric Epilepsy: Expert Opinions
August 01, 2018Cognitive and linguistic deficits have been cited as risk factors for psychiatric comorbidity in pediatric epilepsy, along with family factors such as parenting style and quality of the parent-child relationship.
Disease-Specific ICD Code Helps Identify Infantile Spasms in Claims Data
July 23, 2018Claims data spanning 4 years were obtained from a pediatric accountable care organization.
Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed
July 20, 2018The safety and efficacy of clobazam monotherapy in patients with new-onset focal or generalized seizures was investigated in a new Cochrane systematic review.
Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus
July 20, 2018The efficacy was reported to be significantly higher in patients who had taken benzodiazepines.
Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths
July 19, 2018Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.
Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms
July 19, 2018The FDA has approved an abbreviated New Drug Application for Vigadrone, the generic alternative to Sabril powder for oral solution.
Significant Changes in Serotonin Levels Observed Following Epileptic Seizures
July 10, 2018Investigators sought to examine whether seizures are capable of causing changes in serotonin levels in the peripheral circulation.
Next-Generation Sequencing May Improve Pediatric Epilepsy Tx
July 06, 2018Next-generation sequencing can improve treatment efficacy and reduce hospitalization in children with drug-resistant epilepsy.
First Marijuana-Based Drug Approved to Treat LGS, Dravet Syndrome
June 25, 2018This marks the first approved drug that contains an active ingredient derived from marijuana as well as the first treatment approved for patients with Dravet syndrome.
Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity
June 14, 2018Short-term administration of carbapenem antibiotics may be beneficial in the treatment of VPA overdose in patients with no history of seizure disorder.
Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources
June 13, 2018In individuals who can adequately access healthcare appointments, medications, and other treatments, the combination of driving restrictions and sparse or nonexistent public transportation options interferes with daily living and their overall quality of life.
Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures
June 12, 2018Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.
Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex
June 12, 2018The primary efficacy outcome was achieved in a higher percentage of patients in the exposure range of 9 to 15 ng/mL compared with patients in the 3 to 7 ng/mL and >7 to 9 ng/mL ranges.
Women With Epilepsy More Likely to Have Major Depressive Disorder
June 11, 2018Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.
Fycompa Granted Priority Review for Pediatric Indications
June 04, 2018The sNDA included data from Study 311 (N=180), an ongoing, open-label, multicenter trial with an extension phase that evaluated the safety, tolerability, and exposure-efficacy relationship of Fycompa oral suspension as adjunctive therapy in children (4 to 11 years) with inadequately controlled POS or PGTC seizures.
Stroke Survivors Have Higher Risk for Subsequent Seizures Than General Population
May 30, 2018At 8 years, the cumulative rate of any hospitalization or emergency department visit for seizure was higher among patients with stroke vs the general population.
Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy
May 28, 2018The results of this study should help reassure and encourage women with epilepsy without a prior diagnosis of infertility or an associated disorder who are seeking pregnancy.
Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects
May 25, 2018The effects of short-term VPA exposure on placental compound carrier expression were examined in this study.
Cannabidiol plus conventional antiepileptics reduces drop seizure frequency in the Lennox-Gastaut syndrome
May 24, 2018Amongst adults and children with the Lennox-Gastaut syndrome, addition of cannabidiol to a conventional antiepileptic regimen reduced drop seizure frequency compared to placebo treated patients.
Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy
May 23, 2018A majority of participants (67%) had reported seeing a neurologist or epilepsy specialist in the past year, with younger adults comprising a higher percentage of these participants.
Briviact Approved for Pediatric Patients With Partial-Onset Seizures
May 18, 2018The expanded approval was supported by extrapolated efficacy data from placebo-controlled studies in adults with partial-onset seizures.
Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs
May 16, 2018The prevalence of major congenital malformations in offspring who are prenatally exposed to antiepileptic drugs is highest among those exposed to carbamazepine, phenobarbital doses of >80 mg/day, valproate of ≤650 mg/day, and levetiracetam at 250 to 4000 mg/day.
Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus
May 14, 2018The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.
Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children
May 09, 2018The approval was based on a 12-week, double-blind, placebo-controlled study (N=295) in pediatric patients 4-17 years of age.
Neurology Advisor Articles
- OCD in Duchenne Muscular Dystrophy Features Distinct Phenotype, Associated Symptoms
- History of Migraine Associated With Higher Risk for Cochlear Disorders
- Vagus Nerve Stimulation in Pediatric Epilepsy: Weighing the Risks and Benefits
- High Treatment Adherence and Quality of Life Observed With Fingolimod
- Gender Differences in the Epidemiology of Migraine
- Some Statins May Be Associated With Cognition, Memory Deficits
- Neuropathic Pain Treatments
- Cannabis for Multiple Sclerosis: Prescriber's Perspective
- New Monoclonal Antibody BAN2401 Reduces Amyloid Plaques, Improves Cognition in Alzheimer's
- Nonpharmacologic Interventions for Alzheimer's Have Greater Impact on Outcomes Than Currently Available Medications
- Insurance Status Tied to Higher Self-Perceived Poor/Fair Health
- Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy
- Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS
- Concurrent Non-Motor Functions Strongly Associated With Parkinson Disease
- Feeling Young May Be Reflected in Brain Structure
