Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.
Approximately 20% of patients in this cohort were considered clinically depressed based on GDS criteria.
Although deep brain stimulation, similar to all Parkinson disease therapies, cannot cure, modify, or slow progression of the disease, some recent research suggests that the symptom alleviation and quality-of-life improvement it provides might lead to mild improvements in longevity.
The investigators excluded non-responders to MRgFUS, which may have produced an overestimate of the therapy's benefit in the remaining patients.
MRI-guided focused ultrasound thalamotomy is more effective than deep brain stimulation and significantly cheaper.
Patients in the treatment group experienced significant improvements at 3 months and through 12 months.
Patients experienced a 50% improvement in tremor and motor function.
The authors are primarily concerned with the overlap of therapies being used in these patients.
The device was effective on its own in most patients with essential tremor.
Sergey Brin, co-founder of Google, which acquired Lift Labs, has donated more than $50 million to Parkinson's research.
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