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Etodolac ext-rel Tablets
Arthritis/rheumatic disorders
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Drug Name:

Etodolac ext-rel Tablets Rx

Generic Name and Formulations:
Etodolac 400mg, 500mg, 600mg; ext rel tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Etodolac ext-rel Tablets:

Osteoarthritis. Rheumatoid arthritis. Juvenile rheumatoid arthritis (JRA).

Adult:

Use lowest effective dose for shortest duration. Initially 400–1000mg once daily.

Children:

<6yrs: not established. Use lowest effective dose for shortest duration. Give once daily. JRA: 6–16yrs (20–30kg): 400mg; (31–45kg): 600mg; (46–60kg): 800mg; (>60kg): 1000mg.

Contraindications:

Aspirin allergy. Coronary artery bypass graft surgery.

Warnings/Precautions:

Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Advanced renal disease: not recommended. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic and renal function in long-term therapy. Pre-existing asthma. Discontinue at 1st sign of rash or any other hypersensitivity. Renal or hepatic impairment. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C; 3rd trimester: avoid). Nursing mothers: not recommended.

See Also:

Etodolac Capsules

Etodolac Tablets

Pharmacological Class:

NSAID (pyranocarboxylic acid deriv.).

Interactions:

Avoid concomitant aspirin, salicylates, phenylbutazone, or other NSAIDs. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. May cause false (+) urinary bilirubin test.

Adverse Reactions:

GI upset, dizziness, headache, rash (may be severe), anemia, edema, pruritus, tinnitus; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypersensitivity reactions.

Note:

Formerly known under the brand names Lodine (caps, tabs); Lodine XL (ext-rel tabs).

How Supplied:

Contact supplier

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