General Neurology News Archive

Intellectual Engagement Linked to Cognitive Performance Later

Intellectual Engagement Linked to Cognitive Performance Later

Intellectual engagement is associated with level of cognitive performance in later life but does not influence the trajectory of age-related decline in cognitive performance.

Study Identifies Area Postrema Syndrome Identification Criteria in NMOSD

Study Identifies Area Postrema Syndrome Identification Criteria in NMOSD

Investigators sought to determine how prevalent and severe intractable nausea, vomiting, or hiccups are in patients with AQP4-IgG-positive NMOSD.

Tap Water in Neti Pot Linked to Brain Infection, Death From  Balamuthia mandrillaris

Tap Water in Neti Pot Linked to Brain Infection, Death From Balamuthia mandrillaris

The use of tap water in a nasal-flushing Neti pot likely led to a Seattle woman's death from a Balamuthia mandrillaris brain infection.

Rituximab Effects in Neuromyelitis Optica Spectrum Disorders

Rituximab Effects in Neuromyelitis Optica Spectrum Disorders

Investigators sought to determine whether rituximab would have long-term effects on total and specific immunoglobulins in patients with neuromyelitis optica spectrum disorders.

Neuropsychological Deficits Common in Pediatric Survivors of Cardiac Arrest

Neuropsychological Deficits Common in Pediatric Survivors of Cardiac Arrest

Investigators examined neuropsychological outcomes of children who survived pediatric cardiac arrest.

CDC: Acute Flaccid Myelitis Cases Appear to Have Peaked for 2018

CDC: Acute Flaccid Myelitis Cases Appear to Have Peaked for 2018

The number of cases of acute flaccid myelitis in the United States this year appears to have peaked and is expected to decline for the remainder of 2018.

Case Description Can Reliably Define Acute Flaccid Myelitis

Case Description Can Reliably Define Acute Flaccid Myelitis

A case description can reliably define patients with acute flaccid myelitis.

Assessing for Periodic Paralysis With Long Exercise Test Effective

Assessing for Periodic Paralysis With Long Exercise Test Effective

A recent study supports the use of the long exercise test to diagnose periodic paralysis.

Diagnosing Retinal Vasculopathy With Cerebral Leukoencephalopathy: Case Report

Diagnosing Retinal Vasculopathy With Cerebral Leukoencephalopathy: Case Report

Investigators reviewed a case study of 2 brothers with retinal vasculopathy with cerebral leukoencephalopathy to learn more about this rare disease.

Reducing Residential Lead Exposure May Lower Lead Blood Levels

Reducing Residential Lead Exposure May Lower Lead Blood Levels

Clinicians and public health practitioners should advise expectant parents on ways to prevent childhood lead exposure.

Access to In-Home Support Soon to Be Available for Seniors

Access to In-Home Support Soon to Be Available for Seniors

In-home services such as help with household chores and caregiver respite will be available to seniors with private Medicare Advantage plans in more than 20 states next year.

CDC Announces Acute Flaccid Myelitis Task Force

CDC Announces Acute Flaccid Myelitis Task Force

A task force to investigate a rising number of cases of a rare polio-like disease among children in the United States has been created by the US Centers for Disease Control and Prevention.

No Efficacy Signal for Fluoxetine in EV-D68 Acute Flaccid Myelitis

No Efficacy Signal for Fluoxetine in EV-D68 Acute Flaccid Myelitis

The antiviral agent fluoxetine is well tolerated but is not effective for patients with proven or presumptive enterovirus D68-associated acute flaccid myelitis.

FDA Proposes New Restrictions on Sale of Electronic Nicotine Delivery Systems

FDA Proposes New Restrictions on Sale of Electronic Nicotine Delivery Systems

The announcement comes in the wake of results from the 2018 National Youth Tobacco Survey which showed a 78% increase in current e-cigarette use among high school students from 2017 to 2018.

Researchers Identify Coffee Component That May Provide Neuroprotection

Researchers Identify Coffee Component That May Provide Neuroprotection

The authors found that the compounds known as phenylindanes inhibited the aggregation of the amyloidgenic proteins beta-amyloid and tau.

HHS: Updated Physical Activity Guidelines for Americans Released

HHS: Updated Physical Activity Guidelines for Americans Released

This guidance, updated for the first time since 2008, provides evidence-based recommendations for children (ages 3-17) and adults.

FDA Clears Patient Controller Platform for Stimwave's Neuromodulation Device

FDA Clears Patient Controller Platform for Stimwave's Neuromodulation Device

The new software enables patients to fine-tune the power level and modify programs that were pre-programmed by their clinician to control pain.

Quitting Cannabis Tied to Improved Memory

Quitting Cannabis Tied to Improved Memory

Abstaining from cannabis is associated with improvements in memory and verbal learning in adolescents and young adults.

Higher Serum Cortisol Level Linked to Lower Brain Volumes

Higher Serum Cortisol Level Linked to Lower Brain Volumes

Higher serum cortisol level is associated with lower brain volumes and impaired memory in asymptomatic younger to middle-aged adults.

CDC: Cases of Polio-Like Illness Still Increasing in the US

CDC: Cases of Polio-Like Illness Still Increasing in the US

Cases of a polio-like condition that mainly affects children continue to rise this year in the United States, health officials say.

FDA-Approved Test Provides Pharmacogenetic Reports Directly to Consumers

FDA-Approved Test Provides Pharmacogenetic Reports Directly to Consumers

The 23andMe Personal Genome Service Pharmacogenetic Reports test can detect 33 variants for multiple genes, corresponding to more than 50 commonly prescribed medications and over-the-counter products.

Case Report Highlights Variable Presentation of Serotonin Syndrome

Case Report Highlights Variable Presentation of Serotonin Syndrome

The patient's past medical history was significant for CKD on nightly peritoneal dialysis, T2D mellitus, peripheral neuropathy, gastroesophageal reflux disease, hypertension, and chronic pain.

Organic Food Consumption and Cancer Risk: What's the Link?

Organic Food Consumption and Cancer Risk: What's the Link?

To investigate the link between organic food consumption and cancer risk, study authors conducted a population-based prospective cohort study among French adults.

Trump Administration Announces Plan to Cut Drug Prices

Trump Administration Announces Plan to Cut Drug Prices

In an effort to cut high drug costs, the prices paid by Medicare for certain prescription drugs would be based on those in other advanced industrial nations.

Half of Women to Develop Stroke, Dementia, or Parkinsonism

Half of Women to Develop Stroke, Dementia, or Parkinsonism

One in two women and one in three men will develop dementia, stroke, or parkinsonism during their lifetime.

Modifiable CV Risk Factors Within Healthy Range Indicative of CV Morphology, White Matter Lesions

Modifiable CV Risk Factors Within Healthy Range Indicative of CV Morphology, White Matter Lesions

In multivariable models, associations were observed between cardiovascular risk factors and cerebrovascular morphology, as well as white matter hyperintensity count.

Hospitalization Tied to Brain Abnormalities in Older Adults

Hospitalization Tied to Brain Abnormalities in Older Adults

Hospitalization is associated with lower white matter integrity among older adults.

CDC Warns of Polio-Like Virus Striking More US Children

CDC Warns of Polio-Like Virus Striking More US Children

A rare but devastating polio-like virus appears to have made itself at home in the United States, partially paralyzing hundreds of children.

Nine Cases of Polio-Like Illness Suspected in Children in Illinois

Nine Cases of Polio-Like Illness Suspected in Children in Illinois

Nine recent cases of a rare, polio-like disorder in children are being investigated in Illinois, health officials said yesterday.

Polio-Like Condition in Children on Rise Again in the United States

Polio-Like Condition in Children on Rise Again in the United States

A rare, polio-like condition in children is on the rise again in the United States, with 38 confirmed cases in 16 states so far this year.

FDA Issues Safety Communication Regarding Pen Needle Use

FDA Issues Safety Communication Regarding Pen Needle Use

Standard pen needles have an outer cover and removable inner needle cover, while safety pen needles have an outer cover and a fixed inner needle shield that is not removed before an injection.

New AAN Guidelines for the Management of Disorders of Consciousness

New AAN Guidelines for the Management of Disorders of Consciousness

The new guidelines place a substantial emphasis on the importance of introducing high-quality rehabilitation early in these patients.

Glial Cell Therapy Gets FDA's Orphan Drug Designation for Transverse Myelitis

Glial Cell Therapy Gets FDA's Orphan Drug Designation for Transverse Myelitis

The Company has obtained Investigational New Drug clearance for Phase 1/2a trials of Q-Cells in both TM and amyotrophic lateral sclerosis.

Dozens of Medical Groups Join Forces to Improve Diagnoses

Dozens of Medical Groups Join Forces to Improve Diagnoses

Every nine minutes, a patient in a U.S. hospital dies because a diagnosis was wrong or delayed -- resulting in 80,000 deaths a year. .

Positive Results for Soliris in Neuromyelitis Optica Spectrum Disorder Trial

Positive Results for Soliris in Neuromyelitis Optica Spectrum Disorder Trial

In the PREVENT study, the safety and efficacy of Soliris was compared to placebo in patients with AQP4 auto antibody-positive NMOSD (N=143).

Hospitals Charge 479 Percent of Cost of Drugs on Average

Hospitals Charge 479 Percent of Cost of Drugs on Average

On average, hospitals mark up drugs by 479 percent of their cost, according to a report from The Moran Company, commissioned by the PhRMA.

Prevalence of Autoimmune Encephalitis in Herpes Simplex Encephalitis Explored

Prevalence of Autoimmune Encephalitis in Herpes Simplex Encephalitis Explored

A significant risk factor for autoimmune encephalitis was antibody detection within a 3-week period of herpes simplex encephalitis.

Drug Prices Increase More Than Expected After Shortages

Drug Prices Increase More Than Expected After Shortages

Prices for drugs under shortage increase more than twice as quickly as expected in the absence of a shortage.

Updated Contraindications, Dosing for Gaucher Disease Treatment Cerdelga

Updated Contraindications, Dosing for Gaucher Disease Treatment Cerdelga

Cerdelga is indicated for the long-term treatment of adult patients with Gaucher disease type 1 who are CYP2D6 extensive metabolizers, intermediate metabolizers, or poor metabolizers as detected by an FDA-cleared test.

Decline of Subacute Sclerosing Panencephalitis Mortality Linked With Increased Vaccinations

Decline of Subacute Sclerosing Panencephalitis Mortality Linked With Increased Vaccinations

Age-specific mortality from subacute sclerosing panencephalitis, the neurodegenerative disease caused by the measles virus, is reflective of changes in measles age distributions, and the condition could disappear in the United States if measles vaccination rates remain high.

Vascular Risk Factors for Brain Calcification in Seniors Identified

Vascular Risk Factors for Brain Calcification in Seniors Identified

Diabetes and smoking are vascular risk factors associated with hippocampal calcification in older patients with memory issues.

Generic Substitutes, Therapeutic Interchange Can Save Money

Generic Substitutes, Therapeutic Interchange Can Save Money

Promoting generic substitution and therapeutic interchange can save money compared with spending on brand-name combination medications.

Doctors' Intuition Linked to Number of Imaging Tests Ordered

Doctors' Intuition Linked to Number of Imaging Tests Ordered

Doctors' intuition plays a role in determining how many imaging tests are ordered for a patient.

Aortic Stiffness Linked to Worse Cerebral Hemodynamics in Older Adults

Aortic Stiffness Linked to Worse Cerebral Hemodynamics in Older Adults

The investigators sought to explore how aortic stiffening is linked to resting cerebral blood flow and cerebrovascular reactivity in older adults.

Most Surgical Residents Want Financial Education

Most Surgical Residents Want Financial Education

Surgical residents feel strongly that personal financial education should be offered during medical training.

Doctors Often Not Discussing Risk Factors With Patients

Doctors Often Not Discussing Risk Factors With Patients

Patients report that doctors are routinely not discussing known risk factors for common causes of death.

DEA Proposal Will Significantly Cut Opioid Manufacturing in 2019

DEA Proposal Will Significantly Cut Opioid Manufacturing in 2019

Last year, the DEA proposed a 20% reduction in the manufacturing of controlled substances for 2018 compared to 2017.

Court Rules That U.S. Must Halt Sales of Pesticide Chlorpyrifos

Court Rules That U.S. Must Halt Sales of Pesticide Chlorpyrifos

The Environmental Protection Agency must remove the pesticide chlorpyrifos from sale in the United States within 60 days, a federal appeals court ordered yesterday.

Feeling Young May Be Reflected in Brain Structure

Feeling Young May Be Reflected in Brain Structure

People who feel younger than their age show fewer signs of brain aging than those who feel their age or older than their age.

Advance Care Planning Doesn't Aid Quality of Life

Advance Care Planning Doesn't Aid Quality of Life

Advance care planning in frail older adults does not increase patient activation or quality of life.

FDA Grants Orphan Drug Status to Angelman Syndrome Treatment

FDA Grants Orphan Drug Status to Angelman Syndrome Treatment

Delay or lack of speech, seizures, and walking/balance disorders are some of the symptoms associated with AS.

Anti-CD47 Antibody Granted Orphan Drug Designation for Multiple Myeloma

Anti-CD47 Antibody Granted Orphan Drug Designation for Multiple Myeloma

The FDA has granted Orphan Drug designation to Surface Oncology's lead investigational candidate SRF231, a potential treatment for patients with multiple myeloma.

FDA: Individual Blood Donations No Longer Need to Be Tested for Zika Virus

FDA: Individual Blood Donations No Longer Need to Be Tested for Zika Virus

Individual blood donations will no longer need to be tested for the Zika virus.

Anticonvulsants Seem to Be Ineffective for Low Back Pain

Anticonvulsants Seem to Be Ineffective for Low Back Pain

Anticonvulsant drugs are ineffective for chronic low back pain and can cause harm, despite a recent increase in prescribing.

Drug Used for Reversal of Neuromuscular Block Recalled Due to Mislabeling

Drug Used for Reversal of Neuromuscular Block Recalled Due to Mislabeling

Neostigmine Methylsulfate Injection, a cholinesterase inhibitor, is indicated to reverse the effects of non-depolarizing neuromuscular blockers after surgery.

Menkes Disease Treatment Granted Fast Track Status by FDA

Menkes Disease Treatment Granted Fast Track Status by FDA

CUTX-101, a subcutaneous injectable formulation of copper histidinate, is designed to supplement blood and brain copper levels in patients with Menkes disease.

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes can spread the Zika virus.

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis use is associated with psychosis symptoms during adolescence.

One-Third of U.S. Children, Teens Use Dietary Supplements

One-Third of U.S. Children, Teens Use Dietary Supplements

Approximately one-third of US children and adolescents use dietary supplements.

IV Fluid Specs Do Not Influence Neuro Outcomes in Kids With DKA

IV Fluid Specs Do Not Influence Neuro Outcomes in Kids With DKA

Neurologic outcomes in children with diabetic ketoacidosis are similar regardless of the rate of administration or the NaCl content of intravenous fluids.

White Matter Hyperintensities in RCVS Vary Over Time

White Matter Hyperintensities in RCVS Vary Over Time

White matter hyperintense lesions in patients with reversible cerebral vasoconstriction syndrome change over time in a manner that parallels disease severity.

Should Genealogy Data Be Used for Criminal Justice Purposes?

Should Genealogy Data Be Used for Criminal Justice Purposes?

Informed consent, privacy, and justice concerns are 3 issues that should be addressed before the use of online genealogy data in criminal cases becomes widely adopted.

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Brain autopsies of participants of the Rush Memory Aging project (n=428) were studied to identify the association between brain pathologies and total daily physical activity and mortality.

Lenti-D Gets Breakthrough Tx Designation for Cerebral Adrenoleukodystrophy

Lenti-D Gets Breakthrough Tx Designation for Cerebral Adrenoleukodystrophy

The FDA has granted Breakthrough Therapy designation to Lenti-D for the treatment of patients with cerebral adrenoleukodystrophy.

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

FDA: New Med Guide for Patients Receiving Gadolinium-Based Contrast Agents

FDA: New Med Guide for Patients Receiving Gadolinium-Based Contrast Agents

These Medication Guides should be provided the first time an outpatient receives a GBCA injection at an MRI center; hospital patients are not required to receive a Medication Guide.

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

Evidence on whether the implementation of prescription drug monitory programs increases or decreases opioid-related overdoses was found to be "largely insufficient".

Lightning Can Affect Deep Brain Stimulation Devices

Lightning Can Affect Deep Brain Stimulation Devices

Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative fateful life events in midlife are associated with advanced predicted brain aging.

Atraumatic Needles Reduce Headache Incidence Following Lumbar Puncture

Atraumatic Needles Reduce Headache Incidence Following Lumbar Puncture

Investigators assessed the impact of atraumatic vs conventional needles on patient outcomes after lumbar puncture.

Later Natural Menopause Can Benefit Future Verbal Memory

Later Natural Menopause Can Benefit Future Verbal Memory

Women who have a later natural menopause maintain a small benefit in verbal memory compared with women with earlier menopause.

Untrimmed Toenails: A Marker of Functional Status in Older Patients?

Untrimmed Toenails: A Marker of Functional Status in Older Patients?

For older patients, toenail length can provide important insight into a patient's functional status.

Preserved Neurogenesis in Hippocampus of Healthy Seniors

Preserved Neurogenesis in Hippocampus of Healthy Seniors

Noting that aging humans are thought to exhibit waning neurogenesis and exercise-induced angiogenesis, researchers examined whole-autopsy hippocampi from healthy humans.

Relapse in Major Depression Linked to Brain Cortical Changes

Relapse in Major Depression Linked to Brain Cortical Changes

For patients with major depressive disorde, relapse is associated with brain cortical changes over two years.

Early Infection With Zika Virus Associated With More Birth Defects in Pregnancy

Early Infection With Zika Virus Associated With More Birth Defects in Pregnancy

Among pregnant women with Zika virus infection, birth defects were reported more often in fetuses and infants whose mothers had been infected with the virus early in their pregnancies.

Predicting Neurological Outcome in Unconscious Cardiac Arrest With White Matter Fractional Anisotropy

Predicting Neurological Outcome in Unconscious Cardiac Arrest With White Matter Fractional Anisotropy

The normalized WWM-FA value demonstrated the greatest prognostic accuracy compared with MRI sequences or standard criteria for unfavorable neurological outcome.

Hormone Therapy May Impact Brain Structure, Cognition

Hormone Therapy May Impact Brain Structure, Cognition

3 years after menopausal HT, change in brain volumes were not significantly different from placebo.

Anesthesia, Surgery Affect Postoperative Neurological Outcomes

Anesthesia, Surgery Affect Postoperative Neurological Outcomes

Investigators examined plasma tau concentrations in blood samples obtained from patients who received general anesthesia for surgery.

Altered Neural Responses in Memory Processing in T1DM

Altered Neural Responses in Memory Processing in T1DM

Significantly stronger neural responses in superior parietal cortices during memory encoding in T1DM.

Zika Virus-Associated Neurogenic Bladder Requires Prompt Management

Zika Virus-Associated Neurogenic Bladder Requires Prompt Management

Prompt identification may help reduce the risk for subsequent renal failure and minimize overall disease burden.

FDA Fast Tracks Treatment for Fragile X Syndrome

FDA Fast Tracks Treatment for Fragile X Syndrome

OV101 has previously been granted Orphan Drug status for Fragile X and Fast Track status for Angelman syndrome.

No Benefit for MRI After Normal Cervical CT in Blunt Trauma

No Benefit for MRI After Normal Cervical CT in Blunt Trauma

MRI had lower health benefit and higher cost compared with no follow-up after normal CT findings.

Hep C Compounds Alcoholism's Effect on Brain Volume

Hep C Compounds Alcoholism's Effect on Brain Volume

Deleterious effect of alcohol dependence on frontal cortical volumes also compounded by drug use.

Gut Bacteria May Be Tied to Brain Dysfunction From Sepsis

Gut Bacteria May Be Tied to Brain Dysfunction From Sepsis

Presence of bacteria is associated with higher neuroinflammatory markers in mice and humans.

Treatment Effects Often Exaggerated in Early Clinical Studies

Treatment Effects Often Exaggerated in Early Clinical Studies

Findings in early clinical studies that evaluate drugs or devices for chronic conditions are often exaggerated.

Triptans Plus SSRI/SNRI Use Associated With Lower Risk for Serotonin Syndrome

Triptans Plus SSRI/SNRI Use Associated With Lower Risk for Serotonin Syndrome

A low risk of serotonin syndrome is seen in association with concomitant use of triptans and SSRIs.

Uber Health Transports Patients to Appointments

Uber Health Transports Patients to Appointments

Uber has a new system that allows physician offices to book rides for patients up to 30 days in advance.

Early Hyperoxia Exposure Linked to Poor Neurologic Function After Cardiac Arrest Resuscitation

Early Hyperoxia Exposure Linked to Poor Neurologic Function After Cardiac Arrest Resuscitation

A significantly greater proportion of patients with early hyperoxia exposure experienced poor neurological function vs patients without exposure.

CNS Abnormalities Common in Erdheim-Chester Disease

CNS Abnormalities Common in Erdheim-Chester Disease

Cognitive change, diplopia, dysarthria, dysphagia, focal sensory deficit, focal motor deficit, headache, and imbalance, were noted in 47% of the cohort.

Are Casual Observers Able to Accurately Localize Areas of Facial Paralysis?

Are Casual Observers Able to Accurately Localize Areas of Facial Paralysis?

Ability to identify facial paralysis increases with the severity of the condition.

US Will Produce Radioisotope for MRI, FDA Says

US Will Produce Radioisotope for MRI, FDA Says

The FDA announced the approval of the RadioGenix System.

Aging-Related Brain Changes No Different in HIV Positive, Negative

Aging-Related Brain Changes No Different in HIV Positive, Negative

HIV-positive patients with virological suppression did not have different rates of aging-relating cognitive decline compared with HIV-negative patients.

Fentanyl Use Associated With Amnesia: Case Report

Fentanyl Use Associated With Amnesia: Case Report

Another case of unusual amnestic syndrome that includes bilateral hippocampal lesions on MRI has been described.

FDA Reviewing NDA for Hereditary aTTR Amyloidosis Gene-Silencing Therapy

FDA Reviewing NDA for Hereditary aTTR Amyloidosis Gene-Silencing Therapy

The FDA has accepted Alnylam's New Drug Application for patisiran, and investigational drug for treating hereditary aTTR amyloidosis, for priority review.

Zika Virus-Related Birth Defects Saw Increase in 2016

Zika Virus-Related Birth Defects Saw Increase in 2016

In the second half of 2016, there was an increase in the number of birth defects potentially related to Zika virus infection.

Zika Vaccine Fast-Tracked by FDA

Zika Vaccine Fast-Tracked by FDA

TAK-426, and investigational drug for Zika virus, has been granted Fast Track desgination by the FDA.

Hepatitis C Drug May Treat Zika Virus

Hepatitis C Drug May Treat Zika Virus

The HCV treatment, sofosbuvir was found to be effective in treating the Zika virus.

Spastic Arm Paralysis Improved With C7 Nerve Transfer

Spastic Arm Paralysis Improved With C7 Nerve Transfer

Patients who underwent C7 nerve transfer and rehabilitation experienced better functional improvement than those who underwent rehabilitation alone.

CES 2018: Top Medical Technology

CES 2018: Top Medical Technology

The CES exhibit has presented an impressive array of medical technology.

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