Overall and progression-free survival were superior with temozolomide.

Researchers sought to develop and validate an MRI radiomics prediction model through a machine learning-based method to predict the survival of patients with glioma.

Researchers sought to evaluate the activity and safety of dabrafenib plus trametinib in adult patients with recurrent or progressive BRAF V600E -mutation–positive high-grade and low-grade glioma.

The researchers sought to assess the safety and efficacy of cabozantinib to treat brain metastases in patients with metastatic renal cell carcinoma.

Researchers applied a machine learning strategy in a longitudinal analysis of clinical features linked to neurofibromatosis type 1 in pediatric patients.

The combination of nivolumab with ipilimumab is an effective treatment option for patients with advanced melanoma with asymptomatic brain metastases

Study researchers evaluated the incidence and risk factors for seizure development among patients with brain metastases.

Findings from the study showed 44% of patients treated with berubicin experienced a statistically significant improvement in progression free survival.

In the era of increasing survival of cancer patients, there are also changes in the presentation and outcomes of patients with pituitary metastasis.

The application is supported by data from 2 pivotal open-label, randomized phase 3 trials (SIOPEL 6 and ACCL0431), which compared the efficacy of sodium thiosulfate plus cisplatin to cisplatin alone for the prevention of cisplatin-induced hearing loss.

The Food and Drug Administration (FDA) has granted Orphan Drug Designation to zotiraciclib (Adastra Pharmaceuticals) for the treatment of glioma.

Visual symptoms are a vital component of the morbidity encountered in patients with pituitary adenoma, can present at all stages of the disease, and may negatively affect daily activities and overall quality of life, a new review claims.

AbbVie has halted enrollment in all ongoing studies of depatuxizumab mafodotin, after an Independent Data Monitoring Committee (IDMC) recommended a phase 3 study of the treatment be stopped due to a lack of survival benefit.

Highest incidence seen for patients with non-small cell lung cancer and triple-negative breast cancer

According to researchers, neovascularization is more common in glioblastoma, and extravasation is more common in primary CNS lymphoma.

This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.

In certain parts of the analysis, the use of selective COX-2 inhibitors and metamizol was associated with inferior patient survival.

In preclinical models, the inhibition of phosphorylated STAT3 (p-STAT3) by WP1066 resulted in the direct attack of various tumor cells.

PVSRIPO is a prototypic oncolytic recombinant polio virus vaccine that recognizes the poliovirus receptor CD155, which is widely expressed in neoplastic cells of solid tumors.

Participants receiving TTFields with temozolomide experienced significantly longer deterioration-free survival for global health vs those receiving temozolomide only.

The FDA has granted full approval of Avastin for the treatment of glioblastoma.

1p/19q non-co-deleted anaplastic gliomas are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumors.

The use of postoperative stereotactic radiosurgery could be a substitute for whole-brain radiotherapy, which has been linked to cognitive adverse effects.

Despite it being a standard of care, more or more pediatric patients are deferring PORT.

Intracranial disease control at 3 months was better with combination therapy; however it did not appear to impact overall survival.

GTR increases survival by about 61% at 1 year compared to STR.

The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers.