Investigators evaluated the evolution of pain among patients undergoing total knee replacement and factors contributing to its persistence.

Authors of a prospective cohort study evaluated the impact of migraine history and migraine medication use on risk for spontaneous abortion.

Investigators searched publication databases for studies evaluating depression and psychological outcomes among patients with enterostomy.

Researchers sought to determine how the timing of return to school is associated with later symptom burden 14 days postinjury.

In a phase 3 trial, researchers evaluated matching efficacy, safety, and immunogenicity between biosim-NTZ and ref-NTZ in patients with RRMS.

Black patients significantly less likely than non-Hispanic Whites to receive treatment for arousal, spasticity, mood at 14 days

Authors say automated approach could be used to improve early autism screening

The association between skin barrier function and cognition is investigated.

The Company has completed a phase 2 trial which evaluated the efficacy and safety of oral ketamine in patients with Rett syndrome.

Investigators from the University of Oslo and the Norwegian Institute of Public Health sourced data for this prospective cohort study from the population-based Mother, Father and Child Cohort Study which pooled data from linked Norwegian registries.

How does sleep duration affect asthma control and exacerbations, and what clinical characteristics are found in patients who have with varying levels of sleep duration?

Researchers sought to assess the structural and functional effects in the brain of patients with takotsubo syndrome.

Researchers sought to assess the role of APOE genotype and age at HRT initiation on the heterogeneity in cognitive response to HRT.

Findings significant and similar for fine particulate matter, nitrogen dioxide, and nitric oxide

Three or more mild concussions linked to worse cognition later in life

Investigators searched publication databases through June 2021 for studies reporting metabolic effects from antipsychotic treatments in the setting of schizophrenia.

Investigators sourced data for this study from the Stockholm Major Depressive Disorder Cohort. Between 2010 and 2018, all patients in the Stockholm region who met the criteria for MDD were enrolled in the cohort.

Investigators sought to evaluate the association between early childhood sleep and probable childhood ADHD diagnosis and if these prospective associations are mediated by childhood circulating inflammatory markers.

Investigators conducted a multicenter, double-blind, randomized, placebo-controlled trial to evaluate the impact of cannabinoids on peripheral neuropathic pain.

Researchers sought to assess the diagnostic value of 18F-SynVesT-1 PET as a marker of ALS pathology and explore whether specific density signatures are present in ALS with different subtypes.

In a retrospective cohort study, researchers assessed mRNA COVID-19 vaccine uptake and factors associated with this uptake among immunocompromised individuals.

A team of investigators evaluated numerous factors associated with the management of pain among residents of nursing homes with dementia.

Researchers evaluated whether there is an association between rotavirus infection and extraintestinal complications in pediatric patients.

Algorithm was consistently more accurate than trained clinical evaluators for predicting outcomes based on pain drawings

Social isolation may be a modifiable risk factor for preventing Alzheimer disease-related dementias, authors say

Authors say this may reflect peer influence on substance use, as decreases were not seen for older adults

Loneliness still increases risk even if individual is not socially isolated

Researchers sought to investigate seizure outcomes following SARS-CoV-2 mRNA vaccination in people with epilepsy.

Researchers sought to assess the spread of several potentially toxic elements in autopsied brains of people with and without MS.

The CD20-directed cytolytic antibody therapy was approved based on data from two phase 3 trials.