Generic Name and Formulations:
Clonidine HCl 0.1mg, 0.2mg; extended-release tablets.
Concordia Pharmaceuticals Inc.
Indications for KAPVAY:
Attention deficit hyperactivity disorder (ADHD).
<6yrs: not recommended. Swallow whole. Titrate by response. Initially 0.1mg at bedtime for 1 week, then 0.1mg twice daily for 1 week, then 0.1mg in the morning and 0.2mg at bedtime for 1 week, then 0.2mg twice daily. Withdraw gradually; reduce by 0.1mg/day at 3–7 day intervals. Renal dysfunction: may need reduced dose.
Hypotension, bradycardia, heart block, vascular disease, cardio- or cerebrovascular disease, chronic renal failure, conduction disturbances: uptitrate slowly and monitor. History of, or conditions that predispose to syncope. Monitor pulse, BP. Maintain adequate hydration. Reevaluate periodically. Pregnancy (Category C). Nursing mothers.
Central alpha-2 agonist.
Potentiates alcohol, other CNS depressants, antihypertensives. Hypotensive effect may be antagonized by tricyclic antidepressants. Additive AV block, bradycardia with drugs that affect cardiac conduction (eg, digitalis, calcium channel blockers, β-blockers). Avoid other forms of clonidine. May need to adjust dose of concurrent stimulant medication.
Somnolence, fatigue, upper respiratory tract infection, irritability, sore throat, insomnia, nightmares, emotional disorder, constipation, nasal congestion, fever, dry mouth, ear pain.
Neurology Advisor Articles
- Erenumab Superior to Placebo for Reducing Migraine Disability, Improving HRQoL
- Managing Status Epilepticus in Palliative Care: Accounting for Patient and Family Experience
- Congress Passes Bill to Fight Opioid Crisis
- Physical Activity Decreases Vascular Comorbidities in Multiple Sclerosis
- Review of Factors Impacting Sport-Related Concussion Headaches
- Anodal tDCS Offers Possible Benefit for Improving Item Recall in Post-Stroke Aphasia
- Hospitalization Tied to Brain Abnormalities in Older Adults
- Spending Often Persists in High-Cost Medicare-Medicaid Eligible
- Skills-Based Intervention Did Not Cut Systolic BP After Stroke, TIA
- High Frequency of Headaches Following Dialysis Associated With BUN and Blood Pressure