Elevated WBC Count
Consider white blood cell (WBC) proliferation in patients with infections and other inflammatory states, such as autoimmune disorders.
An increase in neutrophils commonly occurs during a bacterial infection.
Lymphocytosis can be found in tuberculosis (TB), acute bowel infections, and infectious mononucleosis.
Monocyte count is usually increased along with an elevated lymphocyte count.
Eosinophils can become increased in patients with allergic disorders, asthma, certain parasitic, and dermatologic disorders.
Elevated WBC counts may also be detected in patients with a variety of different types of leukemia and lymphomas.
It is important to promptly recognize an elevated WBC count associated with a diagnosis of leukemia or lymphoma.
Commonly Encountered Situations
Non-neoplastic proliferations of WBCs most commonly involve an increase in neutrophils with bacterial infection.
Elevation in lymphocytes and monocytes in patients with autoimmune disease is also frequently encountered.
Suggested Additional Lab Testing
The most important test is the WBC count and differential.
Peripheral blood smear and bone marrow aspirate, with or without bone marrow biopsy, is informative in the diagnosis of certain WBC proliferative states.
Serum protein electrophoresis with further evaluation is indicated if a plasma cell dyscrasia is found.
An evaluation for infection, either bacterial or parasitic, is useful if there is an increase in eosinophils.
Tests for autoimmune diseases (e.g., systemic lupus erythematous [SLE], rheumatoid arthritis) may explain an elevated lymphocyte and monocyte cell count.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Next Article in LabMed
Neurology Advisor Articles
- OCD in Duchenne Muscular Dystrophy Features Distinct Phenotype, Associated Symptoms
- History of Migraine Associated With Higher Risk for Cochlear Disorders
- Vagus Nerve Stimulation in Pediatric Epilepsy: Weighing the Risks and Benefits
- High Treatment Adherence and Quality of Life Observed With Fingolimod
- Gender Differences in the Epidemiology of Migraine
- Some Statins May Be Associated With Cognition, Memory Deficits
- Neuropathic Pain Treatments
- Cannabis for Multiple Sclerosis: Prescriber's Perspective
- New Monoclonal Antibody BAN2401 Reduces Amyloid Plaques, Improves Cognition in Alzheimer's
- Nonpharmacologic Interventions for Alzheimer's Have Greater Impact on Outcomes Than Currently Available Medications
- Insurance Status Tied to Higher Self-Perceived Poor/Fair Health
- Early Treatment Failure More Likely With Carbamazepine vs Lamotrigine in Epilepsy
- Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS
- Concurrent Non-Motor Functions Strongly Associated With Parkinson Disease
- Feeling Young May Be Reflected in Brain Structure