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LIPIODOL
Imaging agents
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Drug Name:

LIPIODOL Rx

Generic Name and Formulations:
Ethiodized oil 480mg/mL; oil for intralymphatic, intrauterine or intra-arterial inj; contains organically combined iodine with ethyl esters of fatty acids of poppy seed oil.

Company:
Guerbet LLC

Therapeutic Use:

RECENT UPDATES

Monograph added.

Indications for LIPIODOL:

For use in: hysterosalpingography in adults, selective hepatic intra-arterial use for imaging tumors in adults with hepatocellular carcinoma (HCC), or lymphography in children and adults.

Adult:

Hysterosalpingography: inject in 2mL increments into endometrial cavity with fluoroscopic control until tubal patency determined; re-image after 24hrs to establish contrast agent has entered peritoneal cavity. Lymphography: inject into lymphatic vessel over ≥1.25hrs (max rate 0.2mL/min) under radiologic monitoring; re-image after 24 or 48hrs to evaluate nodal architecture; (upper extremities): inject 2–4mL; (lower extremities): 6–8mL; (penile): 2–3mL; (cervical): 1–2mL. HCC: inject 1.5–15mL (based on tumor size) slowly under radiologic monitoring; discontinue when stagnation or reflux evident; max dose 20mL. See full labeling.

Children:

Lymphography: inject 1–6mL according to anatomical area; max 0.25mL/kg. See full labeling.

Contraindications:

Hysterosalpingography: pregnancy, uterine bleeding and endocervicitis, acute pelvic inflammatory disease, marked cervical erosion, immediate pre- or postmenstrual phase or within 30 days of curettage or conization. Lymphography: right to left cardiac shunt, advanced pulmonary disease, tissue trauma or hemorrhage advanced neoplastic disease with expected lymphatic obstruction, previous surgery interrupting the lymphatic system, radiation therapy to examined area. HCC: areas of liver where bile ducts are dilated unless external biliary drainage performed prio to injection. For all: hyperthyroidism, traumatic injuries, and recent hemorrhage or bleeding.

Warnings/Precautions:

Severely impaired lung function, cardiorespiratory failure, right-sided cardiac overload, sensitivity to other iodinated contrast agents, bronchial asthma, allergic disorders: avoid. Perform radiological monitoring during injection. Avoid intravasation. Monitor for hypersensitivity reactions during and for ≥30mins after administration. Exacerbation of portal hypertension, hepatic ischemia, hepatic failure. Do not exceed recommended dose. Latent hyperthyroidism, Hashimoto thyroditis, history of thyroid irradiation; may affect thryoid diagnostic results for up to 2yrs post-lymphography. Screen for renal dysfunction prior to intra-arterial use; consider follow-up assessments if history of renal dysfunction. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

May interfere with iodine-based diagnostic tests and radiotherapy.

Pharmacological Class:

Radiopaque contrast agent.

Adverse Reactions:

Hypersensitivity reactions, pulmonary embolism, pulmonary dysfunction, exacerbation of liver disease, procedural complications, abdominal pain, fever, nausea, vomiting, thyroid dysfunction.

Generic Availability:

NO

How Supplied:

Ampoule (10mL)—1

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