Migraine And Headache

Migraine Prevention Treatment Emgality Gets FDA Approval

Migraine Prevention Treatment Emgality Gets FDA Approval

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The approval was based on data from 3 randomized, double-blind, placebo-controlled trials (EVOLVE-1, EVOLVE-2, REGAIN) in patients with either episodic or chronic migraine.

Fremanezumab May Have Long-Term Efficacy as a Prophylactic for Chronic Migraine

Fremanezumab May Have Long-Term Efficacy as a Prophylactic for Chronic Migraine

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Fremanezumab treatment may be efficacious in reducing the number of monthly headache days in the long-term in people with chronic migraine.

Ajovy Injection Approved for Migraine Prevention in Adults

Ajovy Injection Approved for Migraine Prevention in Adults

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The primary efficacy endpoint was the mean change from baseline in the monthly average number of headache days of at least moderate severity during the 3-month treatment period.

Few With Acute Migraine Take Triptans, Many Discontinue the Drug

Few With Acute Migraine Take Triptans, Many Discontinue the Drug

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Few patients were found to take triptan medications to treat acute migraine, and a majority of those who had, discontinued the treatment due to side effects.

Lasmiditan May Be Effective as Acute Migraine Treatment

Lasmiditan May Be Effective as Acute Migraine Treatment

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Lasmiditan was found to be more effective compared with placebo in eliminating pain and other symptoms associated with headache in individuals with migraine.

Use and Overuse of Acute Medications Common Among Migraineurs

Use and Overuse of Acute Medications Common Among Migraineurs

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Investigator analyzed the number of scripts and days of therapy in patients with migraine to determine use and frequency of overuse.

Fremanezumab May Be Efficacious for Comorbid Chronic Migraine and Depression

Fremanezumab May Be Efficacious for Comorbid Chronic Migraine and Depression

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Fremanezumab may be efficacious for the prophylaxis of chronic migraine in individuals with comorbid migraine and moderate/moderate to severe depression.

Lower Dose DFN-11 for Episodic Migraine Associated With Fewer Side Effects

Lower Dose DFN-11 for Episodic Migraine Associated With Fewer Side Effects

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DFN-11, a 3 mg subcutaneous sumatriptan autoinjector, may provide an alternative to SC sumatriptan 6 mg for individuals with episodic migraine.

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

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People with migraines and comorbid mood disorders often need treatments that address both conditions, as well as management of sleep, stress, and lifestyle issues.

Migraine Associated With Increased Risk for Postsurgical 30-Day Hospital Readmission for Pain

Migraine Associated With Increased Risk for Postsurgical 30-Day Hospital Readmission for Pain

Patients with migraine headaches—particularly those accompanied by aura—may be at significantly increased risk for 30-day hospital readmission because of pain after surgery.

Migraine Pain Location May Not Have Clinical Implications

Migraine Pain Location May Not Have Clinical Implications

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The location of migraine pain may not be associated with psychiatric distress, emergency department visits, or healthcare use.

Butalbital/APAP Capsules Launched for Complex Tension Headache

Butalbital/APAP Capsules Launched for Complex Tension Headache

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Mayne Pharma Group announced the availability of Butalbital/Acetaminophen 50mg/300mg Capsules indicated for the relief of the symptom of complex tension headache.

New Device Available for Patients With Episodic Cluster Headache, Migraine

New Device Available for Patients With Episodic Cluster Headache, Migraine

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GammaCore Sapphire, a new non-invasive hand-held device for migraine and episodic cluster headache treatment, has been made available by electroCore.

Chronic Migraine and Medication Overuse Headache Linked to Stress

Chronic Migraine and Medication Overuse Headache Linked to Stress

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The investigators sought to evaluate whether early-life traumatic experiences, stressful life events, and alexithymia are associated with chronic migraine and medication overuse headache.

Risk of Cochlear Disorders Up With History of Migraine

Risk of Cochlear Disorders Up With History of Migraine

The risk of cochlear disorders, especially tinnitus, is increased among patients with a history of migraine.

Efficacy of Mindfulness-Based Therapies Challenged in Chronic Headache

Efficacy of Mindfulness-Based Therapies Challenged in Chronic Headache

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The investigators sought to evaluate the efficacy and safety of mindfulness-based stress reduction and mindfulness-based cognitive therapy in the reduction of the symptoms associated with chronic headaches.

Two-Thirds of Parents Report Their Child Has Had Headache

Two-Thirds of Parents Report Their Child Has Had Headache

Two-thirds of parents report that their child has had a headache not related to a fall or head injury.

White Matter Hyperintensities Demonstrate Specific Spatiotemporal Evolution in Reversible Cerebral Vasoconstriction Syndrome

White Matter Hyperintensities Demonstrate Specific Spatiotemporal Evolution in Reversible Cerebral Vasoconstriction Syndrome

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The characteristics of white matter hyperintensities were assessed to provide information on the underlying mechanisms of these lesions in individuals with reversible cerebral vasoconstriction syndrome.

Co-Prescription of Opioids and Antidepressants Prevalent in Migraine

Co-Prescription of Opioids and Antidepressants Prevalent in Migraine

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Researchers sought to assess the prevalence of concomitant prescribing of opioid analgesics with a triptan or a serotogeneric antidepressant in individuals with migraine.

Fremanezumab Chronic Cluster Headache Study Discontinued

Fremanezumab Chronic Cluster Headache Study Discontinued

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Teva has decided to discontinue part of the ENFORCE Phase 3 clinical development program for fremanezumab.

Levetiracetam Effective as Episodic Migraine Prophylactic

Levetiracetam Effective as Episodic Migraine Prophylactic

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The antiepileptic drug levetiracetam may represent an effective prophylactic treatment option for episodic migraine.

Galcanezumab Beats Placebo for Episodic Migraine

Galcanezumab Beats Placebo for Episodic Migraine

For patients with episodic migraine, galcanezumab is better than placebo for reducing migraine headache days.

Fremanezumab Linked to Fewer Monthly Migraine Days

Fremanezumab Linked to Fewer Monthly Migraine Days

For patients with episodic migraine, fremanezumab is associated with a reduction in the mean number of monthly migraine days.

Fremanezumab effective in preventing episodic migraine

Fremanezumab slightly decreased the amount of headache free days in those with episodic migraines compared to placebo.

Galcanezumab Effective in Phase 3 Episodic Cluster Headache Study

Galcanezumab Effective in Phase 3 Episodic Cluster Headache Study

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The episodic cluster headache trial included a total of 106 patients with an average of 17.5 cluster headache attacks per week at baseline.

Antidepressant Medications and Headache: Is There a Link?

Antidepressant Medications and Headache: Is There a Link?

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Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).

Results From Phase 3 Trial of Migraine Tx Ubrogepant Released

Results From Phase 3 Trial of Migraine Tx Ubrogepant Released

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Allergan announced results from the second Phase 3 trial for their novel acute migraine treatment, ubrogepant.

Pain, Psychiatric Comorbidities More Common in Chronic vs Episodic Migraine

Pain, Psychiatric Comorbidities More Common in Chronic vs Episodic Migraine

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Individuals with chronic vs episodic migraine may be more likely to experience chronic back pain, chronic pain, neck pain, anxiety, and depression.

New Zolmitriptan Intracutaneous System Safe and Effective for Migraine

New Zolmitriptan Intracutaneous System Safe and Effective for Migraine

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Researchers conducted a randomized, double-blond, placebo-controlled, dose-ranging trial to assess the use of a new zolmitriptan intracutaneous delivery system in adults with migraine headache.

Erenumab Shown to Reduce Headache Days for Patients with Episodic Migraine

Erenumab Shown to Reduce Headache Days for Patients with Episodic Migraine

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Researchers assessed the ability of erenumab to decrease the mean number of acute headache days in patients with episodic migraine.

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