Migraine and Headache

Migraine With Aura Linked to Increase in Incident A-Fib

Migraine With Aura Linked to Increase in Incident A-Fib

Migraine with aura is associated with an elevated risk for incident atrial fibrillation.

Hemicrania Continua: Diagnosis and Treatment

Hemicrania Continua: Diagnosis and Treatment

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Hemicrania continua, one of the trigeminal primary headaches, causes intense unilateral pain for ≥3 months.

Barriers to Nonpharmacologic Treatment Adherence for Headache

Barriers to Nonpharmacologic Treatment Adherence for Headache

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Psychological factors such as attitudes, beliefs, and motivation level may affect adherence with nonpharmacologic therapies for headaches.

Vitamin D3 Associated With Reductions in Migraine Days Among Migraineurs

Vitamin D3 Associated With Reductions in Migraine Days Among Migraineurs

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Vitamin D3 may reduce migraine days in patients who experience frequent migraines.

Rimegepant Orally Dissolving Tablet Beneficial in Phase 3 Migraine Trial

Rimegepant Orally Dissolving Tablet Beneficial in Phase 3 Migraine Trial

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Positive topline results were announced from a Phase 3 trial evaluating the safety and efficacy of rimegepant Zydis orally dissolving tablet for the acute treatment of migraine.

Prolonged Aura in Migraine Linked to More Sensory Symptoms

Prolonged Aura in Migraine Linked to More Sensory Symptoms

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Investigators examined the characteristics of prolonged auras associated with migraines.

Treating Acute Migraine During Pregnancy: The Need for Guidelines

Treating Acute Migraine During Pregnancy: The Need for Guidelines

Pregnant women presenting with migraine to acute care settings were found to be treated with therapeutic agents ranging from safe and effective medications to others with unclear efficacy and potential teratogenicity.

FDA Clears nVNS Therapy for Prevention of Cluster Headache

FDA Clears nVNS Therapy for Prevention of Cluster Headache

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The FDA clearance was based on data from 2 studies.

Gender, Social Impairment, Depression Predict Adolescent Headache Prognoses

Gender, Social Impairment, Depression Predict Adolescent Headache Prognoses

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Researchers identified similar characteristics in adolescent girls who experience frequent headaches.

Questionnaire Reliably Predicts Effect of Migraine on Work-Related Duties

Questionnaire Reliably Predicts Effect of Migraine on Work-Related Duties

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The use of the HEADWORK questionnaire may provide insight into the effects of migraines on work productivity and lost workdays.

Pseudotumor Cerebri Syndrome Headache Is Often Episodic With Neck, Shoulder Pain

Pseudotumor Cerebri Syndrome Headache Is Often Episodic With Neck, Shoulder Pain

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A review of patients' medical charts was performed to determine characteristics of headache in pseudotumor cerebri syndrome in adolescents.

High Daily Stress Linked to Migraine Prevalence in Women

High Daily Stress Linked to Migraine Prevalence in Women

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The investigators sought to evaluate the prevalence of migraines, as well as the effect of sex and stress on migraines.

Lasmiditan NDA Submitted for Acute Treatment of Migraine

Lasmiditan NDA Submitted for Acute Treatment of Migraine

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The NDA submission included data from two Phase 3 trials, SAMURAI and SPARTAN.

Jolt Accentuation of Headache Not a Universal Indicator of Acute Meningitis

Jolt Accentuation of Headache Not a Universal Indicator of Acute Meningitis

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The analysis revealed that oversimplifications led to the misconception of jolt accentuation of headache as a stand-alone, universal indicator of acute meningitis.

IV Fluid Use Up, Narcotics Use Down in Patients With Migraine Admitted to ED

IV Fluid Use Up, Narcotics Use Down in Patients With Migraine Admitted to ED

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A study looked at use of IV fluids, ketorolac, dexamethasone, and DRAs prochlorperazine/metoclopramide from 1999-2000 to 2014 in the treatment of patients with migraine admitted to the ED.

Guidelines on the Use of OnabotulinumtoxinA for Chronic Migraine

Guidelines on the Use of OnabotulinumtoxinA for Chronic Migraine

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Researchers and pain experts formulated guidelines for the use of onabotulinumtoxinA for the management of chronic migraine.

Effect of Trigeminal Pathway Symptoms on Quality of Life in Chronic Episodic Migraine

Effect of Trigeminal Pathway Symptoms on Quality of Life in Chronic Episodic Migraine

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Abnormal sleep latency and impaired function related to concentration issues may occur more frequently in patients with chronic vs episodic migraine.

Expert Opinion: CGRP Receptor Antagonist Use in Pediatric Patients With Migraine

Expert Opinion: CGRP Receptor Antagonist Use in Pediatric Patients With Migraine

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Recommendations on the use of these agents in this patient population were published in a Views and Perspectives paper in the journal Headache.

High Frequency of Headaches Following Dialysis Associated With BUN and Blood Pressure

High Frequency of Headaches Following Dialysis Associated With BUN and Blood Pressure

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Compared with patients not reporting headache, patients with HRH had significantly greater differences in pre- and post-BUN values.

Erenumab Superior to Placebo for Reducing Migraine Disability, Improving HRQoL

Erenumab Superior to Placebo for Reducing Migraine Disability, Improving HRQoL

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A significantly lower percentage of patients receiving a 70-mg or 140-mg dose of erenumab had severe disability during treatment compared with placebo.

Migraine Prevention Treatment Emgality Gets FDA Approval

Migraine Prevention Treatment Emgality Gets FDA Approval

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The approval was based on data from 3 randomized, double-blind, placebo-controlled trials (EVOLVE-1, EVOLVE-2, REGAIN) in patients with either episodic or chronic migraine.

Fremanezumab May Have Long-Term Efficacy as a Prophylactic for Chronic Migraine

Fremanezumab May Have Long-Term Efficacy as a Prophylactic for Chronic Migraine

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Fremanezumab treatment may be efficacious in reducing the number of monthly headache days in the long-term in people with chronic migraine.

Ajovy Injection Approved for Migraine Prevention in Adults

Ajovy Injection Approved for Migraine Prevention in Adults

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The primary efficacy endpoint was the mean change from baseline in the monthly average number of headache days of at least moderate severity during the 3-month treatment period.

Few With Acute Migraine Take Triptans, Many Discontinue the Drug

Few With Acute Migraine Take Triptans, Many Discontinue the Drug

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Few patients were found to take triptan medications to treat acute migraine, and a majority of those who had, discontinued the treatment due to side effects.

Lasmiditan May Be Effective as Acute Migraine Treatment

Lasmiditan May Be Effective as Acute Migraine Treatment

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Lasmiditan was found to be more effective compared with placebo in eliminating pain and other symptoms associated with headache in individuals with migraine.

Use and Overuse of Acute Medications Common Among Migraineurs

Use and Overuse of Acute Medications Common Among Migraineurs

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Investigator analyzed the number of scripts and days of therapy in patients with migraine to determine use and frequency of overuse.

Fremanezumab May Be Efficacious for Comorbid Chronic Migraine and Depression

Fremanezumab May Be Efficacious for Comorbid Chronic Migraine and Depression

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Fremanezumab may be efficacious for the prophylaxis of chronic migraine in individuals with comorbid migraine and moderate/moderate to severe depression.

Lower Dose DFN-11 for Episodic Migraine Associated With Fewer Side Effects

Lower Dose DFN-11 for Episodic Migraine Associated With Fewer Side Effects

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DFN-11, a 3 mg subcutaneous sumatriptan autoinjector, may provide an alternative to SC sumatriptan 6 mg for individuals with episodic migraine.

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

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People with migraines and comorbid mood disorders often need treatments that address both conditions, as well as management of sleep, stress, and lifestyle issues.

Migraine Associated With Increased Risk for Postsurgical 30-Day Hospital Readmission for Pain

Migraine Associated With Increased Risk for Postsurgical 30-Day Hospital Readmission for Pain

Patients with migraine headaches—particularly those accompanied by aura—may be at significantly increased risk for 30-day hospital readmission because of pain after surgery.

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