Movement Disorders News Archive
Patients with idiopathic parkinsonism have reduced survival, although survival is dependent on the type and characteristics of the parkinsonian disorder.
The normal human appendix seems to contain pathogenic forms of α-synuclein, which may impact the risk for developing Parkinson disease.
Patients with both Parkinson disease and type 2 diabetes were more likely to have cardiovascular comorbidities than those with only Parkinson disease.
Participants in the RBD group had significantly worse performances on the Symbol Digit Modality Test compared with participants in the hyposmia and NMC cohorts.
Gout may be associated with a higher risk for incident PD in older adults.
The open-label safety study included patients from 3 Gocovri dyskinesia efficacy trials (N=223) and evaluated the long-term safety and tolerability of the treatment.
In order to determine the risk of PD associated with various β2‐adrenoreceptor drugs, the study authors assessed United States Medicare beneficiary data from 2009.
A greater proportion of patients with dysautonomia had supine hypertension compared with patients without dysautonomia.
Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.
Kinase inhibition or allele-specific targeting of mutant LRRK2 may still be a meaningful target for therapeutic development.
The FDA approval was supported by data from bioavailability studies comparing riluzole tablets and Tiglutik oral suspension.
A sensor array has the potential to identify de novo Parkinson's disease (PD) patients with high sensitivity, specificity, and accuracy values.
The studies that included neurocognitive measures demonstrated no significant difference between the use of rTMS and sham-rTMS.
No differences were observed between overground and treadmill walking with regard to stride and stance time.
The inability to compare patients with vs without tremor as well as the inclusion of patients attending a single center, which may reduce the generalizability of the findings.
Rasagiline was associated with a significant effect on survival within 6 months of treatment in an exploratory analysis.
Mutations in the LRP10 gene appear to be common in patients with inherited α-synucleinopathies.
Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.
Investigators developed and evaluated a targeted sequencing approach using a panel of genes involved in movement disorders.
Children with a complex motor disorder, characterized by a combination of movement and posture abnormalities (eg, spasticity and dystonia), were enrolled.
Meige syndrome is a craniofacial dystonia characterized by involuntary muscle contractions of the jaw and around the eyes.
Across the entire cohort, the predominant motor types featured were 70% spastic, 22% dyskinetic (21% dystonic and 1% choreoathetotic), 6% hypotonic, and 2% ataxic.
Researchers collected and analyzed data on age at onset, sex, family history of dystonia, and the presence of associated anatomic sites with dystonia.
Investigators sought to determine if the ECAS diagnostic screening tool is sufficiently sensitive to distinguish between progressive supranuclear palsy and Parkinson disease.
Study investigators enrolled a total of 37 patients with PD who had participated in a larger prospective, controlled exercise study.
Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson's disease psychosis.
There is an increased rate of subsequent Parkinson disease among individuals diagnosed with type 2 diabetes mellitus.
For patients with Parkinson disease, dopamine agonist use is associated with incidence of impulse control disorders in a dose-effect relationship.
A total of 42 consecutive patients with PD who underwent STN-DBS were enrolled in this study.
Sunovion announced that the FDA has accepted the NDA for apomorphine sublingual film to treat motor fluctuations seen in patients with Parkinson's.
Investigators tested functional connectivity between the right and left hypothalamus as well as the other brain regions by using the seed-to-voxel strategy.
A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis.
Individuals with Tourette syndrome or chronic tic disorders have lower likelihood of academic achievement.
There is a significantly increased risk of Parkinson disease in patients with inflammatory bowel disease.
Despite evidence suggesting there is an impact of physical activity and body mass index on the risk for Parkinson disease, a large prospective study published in Neurology shows that there is no significant association between prolonged sitting/inactivity or obesity with PD risk.
Patients with TBI had a higher incidence of PD compared with patients without TBI.
Using information from these assessments, investigators identified participants as having either major psychotic symptoms, isolated minor psychotic symptoms, or no psychotic symptoms.
Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.
Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.
The assessment of psychiatric symptoms relied on only one question in the MDS-UPDRS, potentially leading to underestimation of these symptoms in this cohort.
Patients with IBD who were exposed to anti-TNF therapy had a significant decrease in incidence of PD.
Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.
Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.
Previous research has suggested a genetic and functional link between IBD and PD, however evidence regarding this association has been limited.
Mild traumatic brain injury is associated with increased risk of Parkinson disease among military veterans.
By 2 years, 30% of patients had increased their levodopa dose by ~300mg, indicating that treatment with Gocovri may allow for further levodopa optimization despite the occurrence of dyskinesia.
Investigators conducted a review of electronic medical records to assess functional neurologic disorders in patients with Parkinson disease.
Wearable technology may help monitor on/off states in patients with Parkinson disease in an outpatient setting.
Researchers sought to assess outcomes in hospitalized patients with comorbid Parkinson disease and major depressive disorder following administration of deep brain stimulation.
Researchers found that for men with any occupational exposure to diesel exhaust, the odds ratio for amyotrophic lateral sclerosis increased with increasing lag periods.
Researchers say that tears may be an inexpensive, reliable, and noninvasive biological marker of Parkinson's disease.
Approximately 20% of patients in this cohort were considered clinically depressed based on GDS criteria.
Demoralization is common in patients with Parkinson disease and is associated with motor dysfunction.
ADS-5102 is a promising treatment option: if taken once daily at night, it achieves highest plasma drug concentrations throughout the day when symptoms are most bothersome.
Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.
Seven patients with progressive supranuclear palsy received bilateral pedunculopontine nucleus deep brain stimulation at frequencies of 8, 20, 60, and 130 Hz.
The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia.
Patients who received 100 mg/day riluzole spent significantly more time in stage 4 than patients who were randomly assigned to placebo.
Sunovion announced the submission of its New Drug Application for apomorphine sublingual film for OFF episodes linked with PD.
Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.
Exome capture with a targeted analysis may allow for a molecular level diagnosis in patients with cerebellar ataxia.
Post-LFP change aDBS was deemed safe, tolerable, and effective among patients performing regular daily activities who were also taking additional dopaminergic drugs.
Significant between-group differences in acetylcholinesterase hydrolysis rates were observed among patients with LRRK2 PD, idiopathic PD, LRRK2 mutation carriers without PD, and healthy controls.
Investigators sought to determine whether brain pattern metabolic alterations in PD and FDG-PET SPM could predict dementia risk.
The use of subthalamic stimulation may be beneficial in managing psychobehavioral manifestations of Parkinson disease.
It may be best to deal with the PD subtype characterized by gait difficulty differently from the akinetic-rigid subtype.
The FDA has approved Osmolex ER for the treatment of Parkinson disease.
The SPAN-PD trial found that Inbrija 84mg improved motor functions in Parkinson Disease experiencing off periods.
A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.
By 10 weeks, participants in the treatment group reported significant improvements in quality of life.
Utilizing 123I-FP-CIT SPECT imaging of raphe serotonergic nuclei and putamen dopaminergic terminals may help detect factors that influence response to dopaminergic treatment.
Although treatment with botulinum toxin is effective for pain and posturing associated with cervical dystonia, myoclonus and tremor remain difficult to treat and contribute to compromised quality of life for patients with this movement disorder.
Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.
The investigators excluded non-responders to MRgFUS, which may have produced an overestimate of the therapy's benefit in the remaining patients.
Deep brain stimulation is associated with symptomatic improvement for patients with Tourette syndrome.
The ParkinsonNet network was associated with reduced overall health care costs.
The neuroprotective effect of caffeine has previously been examined in epidemiologic studies.
Adamas announced that Gocovri extended-release capsules are now available for the treatment of dyskinesia in Parkinson's patients.
In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.
The incidence of impulsive compulsive behaviors in patients with Parkinson's may be related to excessive stimulation of dopamine.
Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.
The findings suggest that efforts to help prevent anxiety may help reduce risk for gait freezing.
In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.
Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.
High-intensity treadmill exercise appears to be a safe and tolerable option for physical activity in patients with Parkinson disease.
The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.
Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.
Patient's with depression that have Parkinson's disease have impaired white matter integrity.
More men with Parkinson's disease have caregivers than women.
Investigators analyzed data for baseline factors that may influence weight loss in early parkinson's disease.
The efficacy of focused ultrasound thalamotomy was evaluated for management of medically refractory, tremor-dominant Parkinson disease.
Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.
Ingrezza was well-tolerated in patients with tardive dyskinesia.
Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.
There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.
Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.
Sodium oxybate seems to be effective for patients with Parkinson disease and excessive daytime sleepiness.
The primary endpoint of the study is the change from baseline of the Yale Global Tic Severity Scale between placebo and active treatment groups at the end of week 12.
Deep brain stimulation is traditionally conducted with the patient awake in order to help the ideal target for electrode placement.
Smoking may modify a genetic link with Parkinson disease.
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