Movement Disorders News Archive

Reduced Survival for Patients With Idiopathic Parkinsonism

Reduced Survival for Patients With Idiopathic Parkinsonism

Patients with idiopathic parkinsonism have reduced survival, although survival is dependent on the type and characteristics of the parkinsonian disorder.

Removing Appendix May Lower Risk for Parkinson Disease

Removing Appendix May Lower Risk for Parkinson Disease

The normal human appendix seems to contain pathogenic forms of α-synuclein, which may impact the risk for developing Parkinson disease.

Type 2 Diabetes May Have Adverse Effect on Parkinson Disease Symptoms, Outcomes

Type 2 Diabetes May Have Adverse Effect on Parkinson Disease Symptoms, Outcomes

Patients with both Parkinson disease and type 2 diabetes were more likely to have cardiovascular comorbidities than those with only Parkinson disease.

REM Sleep Behavior Disorder Associated With Worse Cognitive Performance in PD-Susceptible Patients

REM Sleep Behavior Disorder Associated With Worse Cognitive Performance in PD-Susceptible Patients

Participants in the RBD group had significantly worse performances on the Symbol Digit Modality Test compared with participants in the hyposmia and NMC cohorts.

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

Gout may be associated with a higher risk for incident PD in older adults.

Gocovri Treatment Effect Maintained for up to 2 Years in PD Patients With Dyskinesia

Gocovri Treatment Effect Maintained for up to 2 Years in PD Patients With Dyskinesia

The open-label safety study included patients from 3 Gocovri dyskinesia efficacy trials (N=223) and evaluated the long-term safety and tolerability of the treatment.

Do β2‐Adrenoreceptor Medications Affect Parkinson Disease Risk?

Do β2‐Adrenoreceptor Medications Affect Parkinson Disease Risk?

In order to determine the risk of PD associated with various β2‐adrenoreceptor drugs, the study authors assessed United States Medicare beneficiary data from 2009.

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

A greater proportion of patients with dysautonomia had supine hypertension compared with patients without dysautonomia.

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.

Loss of Function Variants in LRRK1 and LRRK2 Not Linked to Parkinson Disease

Loss of Function Variants in LRRK1 and LRRK2 Not Linked to Parkinson Disease

Kinase inhibition or allele-specific targeting of mutant LRRK2 may still be a meaningful target for therapeutic development.

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

The FDA approval was supported by data from bioavailability studies comparing riluzole tablets and Tiglutik oral suspension.

Sensor Array May Detect De Novo Parkinson's Disease in Breath

Sensor Array May Detect De Novo Parkinson's Disease in Breath

A sensor array has the potential to identify de novo Parkinson's disease (PD) patients with high sensitivity, specificity, and accuracy values.

Repetitive TMS for Parkinson Disease Depression Non-Superior to SSRI Therapy

Repetitive TMS for Parkinson Disease Depression Non-Superior to SSRI Therapy

The studies that included neurocognitive measures demonstrated no significant difference between the use of rTMS and sham-rTMS.

Treadmill Walking Associated With Improved Ambulation in Rett Syndrome

Treadmill Walking Associated With Improved Ambulation in Rett Syndrome

No differences were observed between overground and treadmill walking with regard to stride and stance time.

Action Tremor May Have Central Origin in Motor Neuron Disease

Action Tremor May Have Central Origin in Motor Neuron Disease

The inability to compare patients with vs without tremor as well as the inclusion of patients attending a single center, which may reduce the generalizability of the findings.

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

Rasagiline was associated with a significant effect on survival within 6 months of treatment in an exploratory analysis.

LRP10 Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

LRP10 Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

Mutations in the LRP10 gene appear to be common in patients with inherited α-synucleinopathies.

Changes in Glucose Regulation in Parkinson Disease

Changes in Glucose Regulation in Parkinson Disease

Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

Investigators developed and evaluated a targeted sequencing approach using a panel of genes involved in movement disorders.

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

Children with a complex motor disorder, characterized by a combination of movement and posture abnormalities (eg, spasticity and dystonia), were enrolled.

Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

Meige syndrome is a craniofacial dystonia characterized by involuntary muscle contractions of the jaw and around the eyes.

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

Across the entire cohort, the predominant motor types featured were 70% spastic, 22% dyskinetic (21% dystonic and 1% choreoathetotic), 6% hypotonic, and 2% ataxic.

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

Researchers collected and analyzed data on age at onset, sex, family history of dystonia, and the presence of associated anatomic sites with dystonia.

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

Investigators sought to determine if the ECAS diagnostic screening tool is sufficiently sensitive to distinguish between progressive supranuclear palsy and Parkinson disease.

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

Study investigators enrolled a total of 37 patients with PD who had participated in a larger prospective, controlled exercise study.

FDA Approves New Pimavanserin Formulation, Dosage Strength

FDA Approves New Pimavanserin Formulation, Dosage Strength

Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson's disease psychosis.

Strong Link Identified Between T2DM and Parkinson Disease

Strong Link Identified Between T2DM and Parkinson Disease

There is an increased rate of subsequent Parkinson disease among individuals diagnosed with type 2 diabetes mellitus.

Parkinson's Medications Tied to Impulse Control Disorders

Parkinson's Medications Tied to Impulse Control Disorders

For patients with Parkinson disease, dopamine agonist use is associated with incidence of impulse control disorders in a dose-effect relationship.

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

A total of 42 consecutive patients with PD who underwent STN-DBS were enrolled in this study.

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

Sunovion announced that the FDA has accepted the NDA for apomorphine sublingual film to treat motor fluctuations seen in patients with Parkinson's.

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

Investigators tested functional connectivity between the right and left hypothalamus as well as the other brain regions by using the seed-to-voxel strategy.

Immunotherapy Promising for Slowing Progression of ALS

Immunotherapy Promising for Slowing Progression of ALS

A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis.

Academic Underachievement With Tourette, Tic Disorders

Academic Underachievement With Tourette, Tic Disorders

Individuals with Tourette syndrome or chronic tic disorders have lower likelihood of academic achievement.

IBD Associated With Increased Risk of Parkinson Disease

IBD Associated With Increased Risk of Parkinson Disease

There is a significantly increased risk of Parkinson disease in patients with inflammatory bowel disease.

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

Despite evidence suggesting there is an impact of physical activity and body mass index on the risk for Parkinson disease, a large prospective study published in Neurology shows that there is no significant association between prolonged sitting/inactivity or obesity with PD risk.

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

Patients with TBI had a higher incidence of PD compared with patients without TBI.

Enhanced Scale Helps Accurately Identify Psychotic Symptoms in Parkinson Disease

Enhanced Scale Helps Accurately Identify Psychotic Symptoms in Parkinson Disease

Using information from these assessments, investigators identified participants as having either major psychotic symptoms, isolated minor psychotic symptoms, or no psychotic symptoms.

Lightning Can Affect Deep Brain Stimulation Devices

Lightning Can Affect Deep Brain Stimulation Devices

Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

The assessment of psychiatric symptoms relied on only one question in the MDS-UPDRS, potentially leading to underestimation of these symptoms in this cohort.

IBD Associated With Increased Incidence of Parkinson Disease

IBD Associated With Increased Incidence of Parkinson Disease

Patients with IBD who were exposed to anti-TNF therapy had a significant decrease in incidence of PD.

Neuromodulation Therapy Gives Relief From Hand Tremor

Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

Previous research has suggested a genetic and functional link between IBD and PD, however evidence regarding this association has been limited.

Mild TBI May Increase Risk of Parkinson Disease

Mild TBI May Increase Risk of Parkinson Disease

Mild traumatic brain injury is associated with increased risk of Parkinson disease among military veterans.

Long-Term Benefits of Gocovri Observed in PD Patients With Dyskinesia

Long-Term Benefits of Gocovri Observed in PD Patients With Dyskinesia

By 2 years, 30% of patients had increased their levodopa dose by ~300mg, indicating that treatment with Gocovri may allow for further levodopa optimization despite the occurrence of dyskinesia.

Dyskinesia, Psychiatric Disorders Associated With Functional Neurological Symptoms in PD

Dyskinesia, Psychiatric Disorders Associated With Functional Neurological Symptoms in PD

Investigators conducted a review of electronic medical records to assess functional neurologic disorders in patients with Parkinson disease.

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

Wearable technology may help monitor on/off states in patients with Parkinson disease in an outpatient setting.

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

Researchers sought to assess outcomes in hospitalized patients with comorbid Parkinson disease and major depressive disorder following administration of deep brain stimulation.

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Researchers found that for men with any occupational exposure to diesel exhaust, the odds ratio for amyotrophic lateral sclerosis increased with increasing lag periods.

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Researchers say that tears may be an inexpensive, reliable, and noninvasive biological marker of Parkinson's disease.

Connection Between Essential Tremor, Depression Remains Unclear

Connection Between Essential Tremor, Depression Remains Unclear

Approximately 20% of patients in this cohort were considered clinically depressed based on GDS criteria.

Demoralization Common in Patients With Parkinson Disease

Demoralization Common in Patients With Parkinson Disease

Demoralization is common in patients with Parkinson disease and is associated with motor dysfunction.

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

ADS-5102 is a promising treatment option: if taken once daily at night, it achieves highest plasma drug concentrations throughout the day when symptoms are most bothersome.

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.

Progressive Supranuclear Palsy: Pedunculopontine Nucleus DBS May Not Improve Symptoms

Progressive Supranuclear Palsy: Pedunculopontine Nucleus DBS May Not Improve Symptoms

Seven patients with progressive supranuclear palsy received bilateral pedunculopontine nucleus deep brain stimulation at frequencies of 8, 20, 60, and 130 Hz.

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia.

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

Patients who received 100 mg/day riluzole spent significantly more time in stage 4 than patients who were randomly assigned to placebo.

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

Sunovion announced the submission of its New Drug Application for apomorphine sublingual film for OFF episodes linked with PD.

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.

Exome-Targeted Capture Sequencing Can Diagnose Previously-Undetected Ataxia

Exome-Targeted Capture Sequencing Can Diagnose Previously-Undetected Ataxia

Exome capture with a targeted analysis may allow for a molecular level diagnosis in patients with cerebellar ataxia.

Parkinson Disease Symptom Fluctuations Well-Managed With Adaptive Deep Brain Stimulation

Parkinson Disease Symptom Fluctuations Well-Managed With Adaptive Deep Brain Stimulation

Post-LFP change aDBS was deemed safe, tolerable, and effective among patients performing regular daily activities who were also taking additional dopaminergic drugs.

Cholinergic Activity Greater in LRRK2 Mutation Carriers Regardless of Parkinson's Diagnosis

Cholinergic Activity Greater in LRRK2 Mutation Carriers Regardless of Parkinson's Diagnosis

Significant between-group differences in acetylcholinesterase hydrolysis rates were observed among patients with LRRK2 PD, idiopathic PD, LRRK2 mutation carriers without PD, and healthy controls.

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

Investigators sought to determine whether brain pattern metabolic alterations in PD and FDG-PET SPM could predict dementia risk.

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

The use of subthalamic stimulation may be beneficial in managing psychobehavioral manifestations of Parkinson disease.

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

It may be best to deal with the PD subtype characterized by gait difficulty differently from the akinetic-rigid subtype.

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

The FDA has approved Osmolex ER for the treatment of Parkinson disease.

NDA for Inhaled Levodopa Therapy for Parkinson's Accepted by FDA

NDA for Inhaled Levodopa Therapy for Parkinson's Accepted by FDA

The SPAN-PD trial found that Inbrija 84mg improved motor functions in Parkinson Disease experiencing off periods.

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

By 10 weeks, participants in the treatment group reported significant improvements in quality of life.

Resting Tremor Most Common in Early Parkinson Disease

Resting Tremor Most Common in Early Parkinson Disease

Utilizing 123I-FP-CIT SPECT imaging of raphe serotonergic nuclei and putamen dopaminergic terminals may help detect factors that influence response to dopaminergic treatment.

Effect of Escitalopram on Motor, Psychiatric Symptoms in Cervical Dystonia

Effect of Escitalopram on Motor, Psychiatric Symptoms in Cervical Dystonia

Although treatment with botulinum toxin is effective for pain and posturing associated with cervical dystonia, myoclonus and tremor remain difficult to treat and contribute to compromised quality of life for patients with this movement disorder.

Apomorphine Film Effectively Treats Off State in Parkinson Disease

Apomorphine Film Effectively Treats Off State in Parkinson Disease

Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.

Long-Term Tremor Reduction With Magnetic Resonance-Guided Focused Ultrasound Thalamotomy

Long-Term Tremor Reduction With Magnetic Resonance-Guided Focused Ultrasound Thalamotomy

The investigators excluded non-responders to MRgFUS, which may have produced an overestimate of the therapy's benefit in the remaining patients.

Tourette Syndrome Benefits From Deep Brain Stimulation

Tourette Syndrome Benefits From Deep Brain Stimulation

Deep brain stimulation is associated with symptomatic improvement for patients with Tourette syndrome.

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

The ParkinsonNet network was associated with reduced overall health care costs.

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

The neuroprotective effect of caffeine has previously been examined in epidemiologic studies.

Amantadine Now Available to Treat Parkinson Disease Dyskinesia

Amantadine Now Available to Treat Parkinson Disease Dyskinesia

Adamas announced that Gocovri extended-release capsules are now available for the treatment of dyskinesia in Parkinson's patients.

Gait Stability in Parkinson's Improved With Robotic Training

Gait Stability in Parkinson's Improved With Robotic Training

In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.

Levodopa Dose in Parkinson's Linked to Compulsive Sexual Behavior

Levodopa Dose in Parkinson's Linked to Compulsive Sexual Behavior

The incidence of impulsive compulsive behaviors in patients with Parkinson's may be related to excessive stimulation of dopamine.

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.

Anxiety May Help Predict Freezing of Gait in Parkinson Disease

Anxiety May Help Predict Freezing of Gait in Parkinson Disease

The findings suggest that efforts to help prevent anxiety may help reduce risk for gait freezing.

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.

Treadmill Exercise Safe for Patients With Parkinson Disease

Treadmill Exercise Safe for Patients With Parkinson Disease

High-intensity treadmill exercise appears to be a safe and tolerable option for physical activity in patients with Parkinson disease.

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.

Deep Brain Stimulation Improves Survival in Parkinson Disease

Deep Brain Stimulation Improves Survival in Parkinson Disease

Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Patient's with depression that have Parkinson's disease have impaired white matter integrity.

Men With Parkinson Disease More Likely to Have Caregiver

Men With Parkinson Disease More Likely to Have Caregiver

More men with Parkinson's disease have caregivers than women.

Prognostic Significance of Weight Loss in Patients With Early Parkinsonism

Prognostic Significance of Weight Loss in Patients With Early Parkinsonism

Investigators analyzed data for baseline factors that may influence weight loss in early parkinson's disease.

Focused Ultrasound Thalamotomy Promising for Reducing Refractory Tremor in Parkinson Disease

Focused Ultrasound Thalamotomy Promising for Reducing Refractory Tremor in Parkinson Disease

The efficacy of focused ultrasound thalamotomy was evaluated for management of medically refractory, tremor-dominant Parkinson disease.

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.

Valbenazine Assessed for Long-Term Treatment of Tardive Dyskinesia

Valbenazine Assessed for Long-Term Treatment of Tardive Dyskinesia

Ingrezza was well-tolerated in patients with tardive dyskinesia.

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.

Parkinson Disease Onset Linked to LRRK2 Variants

Parkinson Disease Onset Linked to LRRK2 Variants

There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.

Patients With Parkinson Disease Are at High Risk for Depression

Patients With Parkinson Disease Are at High Risk for Depression

Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.

Drug May Help Improve Daytime Sleepiness in Parkinson's

Drug May Help Improve Daytime Sleepiness in Parkinson's

Sodium oxybate seems to be effective for patients with Parkinson disease and excessive daytime sleepiness.

Orphan Drug Designation Granted to Valbenazine for Tourette Syndrome

Orphan Drug Designation Granted to Valbenazine for Tourette Syndrome

The primary endpoint of the study is the change from baseline of the Yale Global Tic Severity Scale between placebo and active treatment groups at the end of week 12.

Asleep Deep Brain Stimulation Linked to Better Outcomes in Parkinson's

Asleep Deep Brain Stimulation Linked to Better Outcomes in Parkinson's

Deep brain stimulation is traditionally conducted with the patient awake in order to help the ideal target for electrode placement.

Smoking Modifies Genetic Link to Parkinson Disease

Smoking Modifies Genetic Link to Parkinson Disease

Smoking may modify a genetic link with Parkinson disease.

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