Movement Disorders

FDA Grants Orphan Drug Designation to Huntington Disease Treatment

FDA Grants Orphan Drug Designation to Huntington Disease Treatment

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In animal studies, the treatment was associated with improvement in both motor and cognitive function.

Inverse Association Between Physical Activity and PD Risk Found in Men

Inverse Association Between Physical Activity and PD Risk Found in Men

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Researchers observed an inverse relationship between moderate to vigorous physical exercise and risk for Parkinson disease.

Multiple System Atrophy: A Common Form of Atypical Parkinsonism

Multiple System Atrophy: A Common Form of Atypical Parkinsonism

Multiple system atrophy is a rare, progressive neurodegenerative condition for which there is currently no cure.

Reduced Survival for Patients With Idiopathic Parkinsonism

Reduced Survival for Patients With Idiopathic Parkinsonism

Patients with idiopathic parkinsonism have reduced survival, although survival is dependent on the type and characteristics of the parkinsonian disorder.

Removing Appendix May Lower Risk for Parkinson Disease

Removing Appendix May Lower Risk for Parkinson Disease

The normal human appendix seems to contain pathogenic forms of α-synuclein, which may impact the risk for developing Parkinson disease.

Type 2 Diabetes May Have Adverse Effect on Parkinson Disease Symptoms, Outcomes

Type 2 Diabetes May Have Adverse Effect on Parkinson Disease Symptoms, Outcomes

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Patients with both Parkinson disease and type 2 diabetes were more likely to have cardiovascular comorbidities than those with only Parkinson disease.

REM Sleep Behavior Disorder Associated With Worse Cognitive Performance in PD-Susceptible Patients

REM Sleep Behavior Disorder Associated With Worse Cognitive Performance in PD-Susceptible Patients

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Participants in the RBD group had significantly worse performances on the Symbol Digit Modality Test compared with participants in the hyposmia and NMC cohorts.

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

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Gout may be associated with a higher risk for incident PD in older adults.

Gocovri Treatment Effect Maintained for up to 2 Years in PD Patients With Dyskinesia

Gocovri Treatment Effect Maintained for up to 2 Years in PD Patients With Dyskinesia

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The open-label safety study included patients from 3 Gocovri dyskinesia efficacy trials (N=223) and evaluated the long-term safety and tolerability of the treatment.

Do β2‐Adrenoreceptor Medications Affect Parkinson Disease Risk?

Do β2‐Adrenoreceptor Medications Affect Parkinson Disease Risk?

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In order to determine the risk of PD associated with various β2‐adrenoreceptor drugs, the study authors assessed United States Medicare beneficiary data from 2009.

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

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A greater proportion of patients with dysautonomia had supine hypertension compared with patients without dysautonomia.

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

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Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.

Loss of Function Variants in <i>LRRK1</i> and <i>LRRK2</i> Not Linked to Parkinson Disease

Loss of Function Variants in LRRK1 and LRRK2 Not Linked to Parkinson Disease

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Kinase inhibition or allele-specific targeting of mutant LRRK2 may still be a meaningful target for therapeutic development.

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

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The FDA approval was supported by data from bioavailability studies comparing riluzole tablets and Tiglutik oral suspension.

Sensor Array May Detect De Novo Parkinson's Disease in Breath

Sensor Array May Detect De Novo Parkinson's Disease in Breath

A sensor array has the potential to identify de novo Parkinson's disease (PD) patients with high sensitivity, specificity, and accuracy values.

Repetitive TMS for Parkinson Disease Depression Non-Superior to SSRI Therapy

Repetitive TMS for Parkinson Disease Depression Non-Superior to SSRI Therapy

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The studies that included neurocognitive measures demonstrated no significant difference between the use of rTMS and sham-rTMS.

Treadmill Walking Associated With Improved Ambulation in Rett Syndrome

Treadmill Walking Associated With Improved Ambulation in Rett Syndrome

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No differences were observed between overground and treadmill walking with regard to stride and stance time.

Action Tremor May Have Central Origin in Motor Neuron Disease

Action Tremor May Have Central Origin in Motor Neuron Disease

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The inability to compare patients with vs without tremor as well as the inclusion of patients attending a single center, which may reduce the generalizability of the findings.

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

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Rasagiline was associated with a significant effect on survival within 6 months of treatment in an exploratory analysis.

<i>LRP10</i> Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

LRP10 Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

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Mutations in the LRP10 gene appear to be common in patients with inherited α-synucleinopathies.

Changes in Glucose Regulation in Parkinson Disease

Changes in Glucose Regulation in Parkinson Disease

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Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

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Investigators developed and evaluated a targeted sequencing approach using a panel of genes involved in movement disorders.

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

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Children with a complex motor disorder, characterized by a combination of movement and posture abnormalities (eg, spasticity and dystonia), were enrolled.

 Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

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Meige syndrome is a craniofacial dystonia characterized by involuntary muscle contractions of the jaw and around the eyes.

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

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Across the entire cohort, the predominant motor types featured were 70% spastic, 22% dyskinetic (21% dystonic and 1% choreoathetotic), 6% hypotonic, and 2% ataxic.

Parkinson Disease Prevalence Severely Underestimated: Parkinson's Foundation Prevalence Project

Parkinson Disease Prevalence Severely Underestimated: Parkinson's Foundation Prevalence Project

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The Parkinson's Foundation Prevalence Project estimates that within the next 2 years, 930,000 people in the United States will be living with the condition; that number is anticipated to rise to 1.2 million by 2030.

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

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Researchers collected and analyzed data on age at onset, sex, family history of dystonia, and the presence of associated anatomic sites with dystonia.

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

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Investigators sought to determine if the ECAS diagnostic screening tool is sufficiently sensitive to distinguish between progressive supranuclear palsy and Parkinson disease.

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

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Study investigators enrolled a total of 37 patients with PD who had participated in a larger prospective, controlled exercise study.

FDA Approves New Pimavanserin Formulation, Dosage Strength

FDA Approves New Pimavanserin Formulation, Dosage Strength

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Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson's disease psychosis.

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