Movement Disorders

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

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A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

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By 10 weeks, participants in the treatment group reported significant improvements in quality of life.

Resting Tremor Most Common in Early Parkinson Disease

Resting Tremor Most Common in Early Parkinson Disease

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Utilizing 123I-FP-CIT SPECT imaging of raphe serotonergic nuclei and putamen dopaminergic terminals may help detect factors that influence response to dopaminergic treatment.

Anesthesia in Parkinson Disease Requires Cautious Care

Anesthesia in Parkinson Disease Requires Cautious Care

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Anesthetic medications have been identified as a potential cause of morbidity in this population due to their interaction with the drugs used to manage Parkinson disease.

Effect of Escitalopram on Motor, Psychiatric Symptoms in Cervical Dystonia

Effect of Escitalopram on Motor, Psychiatric Symptoms in Cervical Dystonia

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Although treatment with botulinum toxin is effective for pain and posturing associated with cervical dystonia, myoclonus and tremor remain difficult to treat and contribute to compromised quality of life for patients with this movement disorder.

Apomorphine Film Effectively Treats Off State in Parkinson Disease

Apomorphine Film Effectively Treats Off State in Parkinson Disease

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Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.

Long-Term Tremor Reduction With Magnetic Resonance-Guided Focused Ultrasound Thalamotomy

Long-Term Tremor Reduction With Magnetic Resonance-Guided Focused Ultrasound Thalamotomy

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The investigators excluded non-responders to MRgFUS, which may have produced an overestimate of the therapy's benefit in the remaining patients.

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

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The ParkinsonNet network was associated with reduced overall health care costs.

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

The neuroprotective effect of caffeine has previously been examined in epidemiologic studies.

Amantadine Now Available to Treat Parkinson Disease Dyskinesia

Amantadine Now Available to Treat Parkinson Disease Dyskinesia

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Adamas announced that Gocovri extended-release capsules are now available for the treatment of dyskinesia in Parkinson's patients.

Gait Stability in Parkinson's Improved With Robotic Training

Gait Stability in Parkinson's Improved With Robotic Training

In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.

Levodopa Dose in Parkinson's Linked to Compulsive Sexual Behavior

Levodopa Dose in Parkinson's Linked to Compulsive Sexual Behavior

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The incidence of impulsive compulsive behaviors in patients with Parkinson's may be related to excessive stimulation of dopamine.

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.

Anxiety May Help Predict Freezing of Gait in Parkinson Disease

Anxiety May Help Predict Freezing of Gait in Parkinson Disease

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The findings suggest that efforts to help prevent anxiety may help reduce risk for gait freezing.

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

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Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.

Treadmill Exercise Safe for Patients With Parkinson Disease

Treadmill Exercise Safe for Patients With Parkinson Disease

High-intensity treadmill exercise appears to be a safe and tolerable option for physical activity in patients with Parkinson disease.

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

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Several studies have uncovered sex-dependent variations in the symptomatic manifestations of Parkinson disease, as well as in the response to dopamine therapies.

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

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The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.

Deep Brain Stimulation Improves Survival in Parkinson Disease

Deep Brain Stimulation Improves Survival in Parkinson Disease

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Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Patient's with depression that have Parkinson's disease have impaired white matter integrity.

Men With Parkinson Disease More Likely to Have Caregiver

Men With Parkinson Disease More Likely to Have Caregiver

More men with Parkinson's disease have caregivers than women.

Prognostic Significance of Weight Loss in Patients With Early Parkinsonism

Prognostic Significance of Weight Loss in Patients With Early Parkinsonism

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Investigators analyzed data for baseline factors that may influence weight loss in early parkinson's disease.

Predicting Rates and Patterns of Progression in Parkinson Disease

Predicting Rates and Patterns of Progression in Parkinson Disease

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Numerous factors are likely contribute to the rate of progression, with different combinations of factors showing relevance for individual patients.

Focused Ultrasound Thalamotomy Promising for Reducing Refractory Tremor in Parkinson Disease

Focused Ultrasound Thalamotomy Promising for Reducing Refractory Tremor in Parkinson Disease

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The efficacy of focused ultrasound thalamotomy was evaluated for management of medically refractory, tremor-dominant Parkinson disease.

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

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Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.

Valbenazine Assessed for Long-Term Treatment of Tardive Dyskinesia

Valbenazine Assessed for Long-Term Treatment of Tardive Dyskinesia

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Ingrezza was well-tolerated in patients with tardive dyskinesia.

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

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Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.

Parkinson Disease Onset Linked to <i>LRRK2</i> Variants

Parkinson Disease Onset Linked to LRRK2 Variants

There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.

Patients With Parkinson Disease Are at High Risk for Depression

Patients With Parkinson Disease Are at High Risk for Depression

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Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.

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