Movement Disorders

Connection Between Essential Tremor, Depression Remains Unclear

Connection Between Essential Tremor, Depression Remains Unclear

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Approximately 20% of patients in this cohort were considered clinically depressed based on GDS criteria.

Demoralization Common in Patients With Parkinson Disease

Demoralization Common in Patients With Parkinson Disease

Demoralization is common in patients with Parkinson disease and is associated with motor dysfunction.

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

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ADS-5102 is a promising treatment option: if taken once daily at night, it achieves highest plasma drug concentrations throughout the day when symptoms are most bothersome.

Progressive Supranuclear Palsy: Pedunculopontine Nucleus DBS May Not Improve Symptoms

Progressive Supranuclear Palsy: Pedunculopontine Nucleus DBS May Not Improve Symptoms

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Seven patients with progressive supranuclear palsy received bilateral pedunculopontine nucleus deep brain stimulation at frequencies of 8, 20, 60, and 130 Hz.

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

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Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

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Although deep brain stimulation, similar to all Parkinson disease therapies, cannot cure, modify, or slow progression of the disease, some recent research suggests that the symptom alleviation and quality-of-life improvement it provides might lead to mild improvements in longevity.

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia.

Old Challenges and New Directions in Managing Tardive Dyskinesia

Old Challenges and New Directions in Managing Tardive Dyskinesia

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"Since the current generation of psychiatrists has been raised on second-generation antipsychotics and has relatively little experience with first-generation antipsychotics, keeping tardive dyskinesia in mind is not, on the whole, part of their experience or training," said Christoph U. Correll, MD.

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

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Patients who received 100 mg/day riluzole spent significantly more time in stage 4 than patients who were randomly assigned to placebo.

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

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Sunovion announced the submission of its New Drug Application for apomorphine sublingual film for OFF episodes linked with PD.

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

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Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.

Palliative Care in Movement Disorders: Recommendations for Improvement

Palliative Care in Movement Disorders: Recommendations for Improvement

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Parkinsonism syndromes are associated with progressive disability and increased mortality, with symptom burden comparable to that of advanced cancer.

Exome-Targeted Capture Sequencing Can Diagnose Previously-Undetected Ataxia

Exome-Targeted Capture Sequencing Can Diagnose Previously-Undetected Ataxia

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Exome capture with a targeted analysis may allow for a molecular level diagnosis in patients with cerebellar ataxia.

Parkinson Disease Symptom Fluctuations Well-Managed With Adaptive Deep Brain Stimulation

Parkinson Disease Symptom Fluctuations Well-Managed With Adaptive Deep Brain Stimulation

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Post-LFP change aDBS was deemed safe, tolerable, and effective among patients performing regular daily activities who were also taking additional dopaminergic drugs.

Cholinergic Activity Greater in <i>LRRK2</i> Mutation Carriers Regardless of Parkinson's Diagnosis

Cholinergic Activity Greater in LRRK2 Mutation Carriers Regardless of Parkinson's Diagnosis

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Significant between-group differences in acetylcholinesterase hydrolysis rates were observed among patients with LRRK2 PD, idiopathic PD, LRRK2 mutation carriers without PD, and healthy controls.

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

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Investigators sought to determine whether brain pattern metabolic alterations in PD and FDG-PET SPM could predict dementia risk.

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

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The use of subthalamic stimulation may be beneficial in managing psychobehavioral manifestations of Parkinson disease.

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

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It may be best to deal with the PD subtype characterized by gait difficulty differently from the akinetic-rigid subtype.

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

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The FDA has approved Osmolex ER for the treatment of Parkinson disease.

NDA for Inhaled Levodopa Therapy for Parkinson's Accepted by FDA

NDA for Inhaled Levodopa Therapy for Parkinson's Accepted by FDA

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The SPAN-PD trial found that Inbrija 84mg improved motor functions in Parkinson Disease experiencing off periods.

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

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A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

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By 10 weeks, participants in the treatment group reported significant improvements in quality of life.

Resting Tremor Most Common in Early Parkinson Disease

Resting Tremor Most Common in Early Parkinson Disease

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Utilizing 123I-FP-CIT SPECT imaging of raphe serotonergic nuclei and putamen dopaminergic terminals may help detect factors that influence response to dopaminergic treatment.

Anesthesia in Parkinson Disease Requires Cautious Care

Anesthesia in Parkinson Disease Requires Cautious Care

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Anesthetic medications have been identified as a potential cause of morbidity in this population due to their interaction with the drugs used to manage Parkinson disease.

Effect of Escitalopram on Motor, Psychiatric Symptoms in Cervical Dystonia

Effect of Escitalopram on Motor, Psychiatric Symptoms in Cervical Dystonia

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Although treatment with botulinum toxin is effective for pain and posturing associated with cervical dystonia, myoclonus and tremor remain difficult to treat and contribute to compromised quality of life for patients with this movement disorder.

Apomorphine Film Effectively Treats Off State in Parkinson Disease

Apomorphine Film Effectively Treats Off State in Parkinson Disease

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Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.

Long-Term Tremor Reduction With Magnetic Resonance-Guided Focused Ultrasound Thalamotomy

Long-Term Tremor Reduction With Magnetic Resonance-Guided Focused Ultrasound Thalamotomy

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The investigators excluded non-responders to MRgFUS, which may have produced an overestimate of the therapy's benefit in the remaining patients.

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

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The ParkinsonNet network was associated with reduced overall health care costs.

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

The neuroprotective effect of caffeine has previously been examined in epidemiologic studies.

Amantadine Now Available to Treat Parkinson Disease Dyskinesia

Amantadine Now Available to Treat Parkinson Disease Dyskinesia

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Adamas announced that Gocovri extended-release capsules are now available for the treatment of dyskinesia in Parkinson's patients.

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