Movement Disorders

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

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A greater proportion of patients with dysautonomia had supine hypertension compared with patients without dysautonomia.

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

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Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.

Loss of Function Variants in <i>LRRK1</i> and <i>LRRK2</i> Not Linked to Parkinson Disease

Loss of Function Variants in LRRK1 and LRRK2 Not Linked to Parkinson Disease

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Kinase inhibition or allele-specific targeting of mutant LRRK2 may still be a meaningful target for therapeutic development.

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

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The FDA approval was supported by data from bioavailability studies comparing riluzole tablets and Tiglutik oral suspension.

Sensor Array May Detect De Novo Parkinson's Disease in Breath

Sensor Array May Detect De Novo Parkinson's Disease in Breath

A sensor array has the potential to identify de novo Parkinson's disease (PD) patients with high sensitivity, specificity, and accuracy values.

Repetitive TMS for Parkinson Disease Depression Non-Superior to SSRI Therapy

Repetitive TMS for Parkinson Disease Depression Non-Superior to SSRI Therapy

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The studies that included neurocognitive measures demonstrated no significant difference between the use of rTMS and sham-rTMS.

Treadmill Walking Associated With Improved Ambulation in Rett Syndrome

Treadmill Walking Associated With Improved Ambulation in Rett Syndrome

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No differences were observed between overground and treadmill walking with regard to stride and stance time.

Action Tremor May Have Central Origin in Motor Neuron Disease

Action Tremor May Have Central Origin in Motor Neuron Disease

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The inability to compare patients with vs without tremor as well as the inclusion of patients attending a single center, which may reduce the generalizability of the findings.

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

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Rasagiline was associated with a significant effect on survival within 6 months of treatment in an exploratory analysis.

<i>LRP10</i> Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

LRP10 Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

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Mutations in the LRP10 gene appear to be common in patients with inherited α-synucleinopathies.

Changes in Glucose Regulation in Parkinson Disease

Changes in Glucose Regulation in Parkinson Disease

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Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

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Investigators developed and evaluated a targeted sequencing approach using a panel of genes involved in movement disorders.

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

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Children with a complex motor disorder, characterized by a combination of movement and posture abnormalities (eg, spasticity and dystonia), were enrolled.

 Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

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Meige syndrome is a craniofacial dystonia characterized by involuntary muscle contractions of the jaw and around the eyes.

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

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Across the entire cohort, the predominant motor types featured were 70% spastic, 22% dyskinetic (21% dystonic and 1% choreoathetotic), 6% hypotonic, and 2% ataxic.

Parkinson Disease Prevalence Severely Underestimated: Parkinson's Foundation Prevalence Project

Parkinson Disease Prevalence Severely Underestimated: Parkinson's Foundation Prevalence Project

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The Parkinson's Foundation Prevalence Project estimates that within the next 2 years, 930,000 people in the United States will be living with the condition; that number is anticipated to rise to 1.2 million by 2030.

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

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Researchers collected and analyzed data on age at onset, sex, family history of dystonia, and the presence of associated anatomic sites with dystonia.

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

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Investigators sought to determine if the ECAS diagnostic screening tool is sufficiently sensitive to distinguish between progressive supranuclear palsy and Parkinson disease.

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

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Study investigators enrolled a total of 37 patients with PD who had participated in a larger prospective, controlled exercise study.

FDA Approves New Pimavanserin Formulation, Dosage Strength

FDA Approves New Pimavanserin Formulation, Dosage Strength

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Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson's disease psychosis.

Strong Link Identified Between T2DM and Parkinson Disease

Strong Link Identified Between T2DM and Parkinson Disease

There is an increased rate of subsequent Parkinson disease among individuals diagnosed with type 2 diabetes mellitus.

Parkinson's Medications Tied to Impulse Control Disorders

Parkinson's Medications Tied to Impulse Control Disorders

For patients with Parkinson disease, dopamine agonist use is associated with incidence of impulse control disorders in a dose-effect relationship.

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

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A total of 42 consecutive patients with PD who underwent STN-DBS were enrolled in this study.

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

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Sunovion announced that the FDA has accepted the NDA for apomorphine sublingual film to treat motor fluctuations seen in patients with Parkinson's.

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

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Investigators tested functional connectivity between the right and left hypothalamus as well as the other brain regions by using the seed-to-voxel strategy.

The Future of Freezing of Gait in Parkinson's: Exploring Potential Treatments and Preventive Strategies

The Future of Freezing of Gait in Parkinson's: Exploring Potential Treatments and Preventive Strategies

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More than half of patients diagnosed with Parkinson disease experience freezing of gait.

Immunotherapy Promising for Slowing Progression of ALS

Immunotherapy Promising for Slowing Progression of ALS

A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis.

Academic Underachievement With Tourette, Tic Disorders

Academic Underachievement With Tourette, Tic Disorders

Individuals with Tourette syndrome or chronic tic disorders have lower likelihood of academic achievement.

Emerging Innovations in Parkinson Disease Treatment: Q&A With Dr Matthew Brodsky

Emerging Innovations in Parkinson Disease Treatment: Q&A With Dr Matthew Brodsky

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Surgical interventions for Parkinson disease are experiencing a swell in innovation, thanks in part to the entry of two additional medical device companies into a field previously dominated by one company.

IBD Associated With Increased Risk of Parkinson Disease

IBD Associated With Increased Risk of Parkinson Disease

There is a significantly increased risk of Parkinson disease in patients with inflammatory bowel disease.

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