Patients in the 2 highest dosing groups saw significant, sustained improvements over the 12-week study.
The FDA has accepted the New Drug Application for solriamfetol for the treatment of sleep disorders.
The US Food and Drug Administration requested that sodium oxybate be studied in pediatric patients.
After influenza infection, the risk for narcolepsy was increased by 2- to 3-fold overall.
Narcolepsy symptoms were most severe in patients taking dopamine agonists.
Researchers are nearly convinced narcolepsy is the result of an autoimmune response, but one crucial factor is still missing.
Sodium oxybate, alone or in combination with modafinil, improved excessive sleepiness in patients with narcolepsy both with and without cataplexy.
There was a statistically significant positive correlation between the Clinical Global Impression of Change (CGI-C) and Patient Global Impression of Change (PGI-C) scales scores.
A study is enrolling children and adolescents to test sodium oxybate's efficacy and safety for narcolepsy and cataplexy.
Prior to the discovery, narcolepsy was largely known to be a genetic disorder.
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