Narcolepsy

Xyrem Approved for Use in Pediatric Patients With Narcolepsy

Xyrem Approved for Use in Pediatric Patients With Narcolepsy

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Efficacy in the pediatric population with narcolepsy was demonstrated in the Phase 2/3 EXPRESS study (N=106) which included patients aged 7 to 17 years with narcolepsy with cataplexy.

Novel Narcolepsy Treatment Gets Orphan Drug Designation

Novel Narcolepsy Treatment Gets Orphan Drug Designation

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The Company stated that they plan to begin a Phase 2 trial of AXS-12 before the end of 2018, with results anticipated for the first half of 2019.

Solriamfetol Associated With Improvement in Narcolepsy Types 1 and 2

Solriamfetol Associated With Improvement in Narcolepsy Types 1 and 2

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Patients in the 2 highest dosing groups saw significant, sustained improvements over the 12-week study.

FDA Accepts NDA for Narcolepsy, OSA-Related Sleepiness Treatment

FDA Accepts NDA for Narcolepsy, OSA-Related Sleepiness Treatment

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The FDA has accepted the New Drug Application for solriamfetol for the treatment of sleep disorders.

Sodium Oxybate May Be Effective for Cataplexy in Pediatric Patients With Narcolepsy

Sodium Oxybate May Be Effective for Cataplexy in Pediatric Patients With Narcolepsy

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The US Food and Drug Administration requested that sodium oxybate be studied in pediatric patients.

Increased Rates of Narcolepsy, Hypersomnia Linked to H1N1 Vaccine

Increased Rates of Narcolepsy, Hypersomnia Linked to H1N1 Vaccine

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After influenza infection, the risk for narcolepsy was increased by 2- to 3-fold overall.

Narcolepsy Symptoms Worsen as Parkinson's Progresses

Narcolepsy Symptoms Worsen as Parkinson's Progresses

Narcolepsy symptoms were most severe in patients taking dopamine agonists.

Narcolepsy and Autoimmune Response: The Missing Link

Narcolepsy and Autoimmune Response: The Missing Link

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Researchers are nearly convinced narcolepsy is the result of an autoimmune response, but one crucial factor is still missing.

Sodium Oxybate Improves Sleepiness in Narcolepsy Without Cataplexy

Sodium Oxybate Improves Sleepiness in Narcolepsy Without Cataplexy

Sodium oxybate, alone or in combination with modafinil, improved excessive sleepiness in patients with narcolepsy both with and without cataplexy.

Patients, Physicians Agree on Narcolepsy Status Change with Novel Drug

Patients, Physicians Agree on Narcolepsy Status Change with Novel Drug

There was a statistically significant positive correlation between the Clinical Global Impression of Change (CGI-C) and Patient Global Impression of Change (PGI-C) scales scores.

Sodium Oxybate Being Evaluated for Pediatric Narcolepsy, Cataplexy

Sodium Oxybate Being Evaluated for Pediatric Narcolepsy, Cataplexy

A study is enrolling children and adolescents to test sodium oxybate's efficacy and safety for narcolepsy and cataplexy.

Narcolepsy May Be the Result of an Autoimmune Response

Narcolepsy May Be the Result of an Autoimmune Response

Prior to the discovery, narcolepsy was largely known to be a genetic disorder.

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