Early Antiretroviral Tx May Resolve Neurologic Symptoms in HIV

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Early Antiretroviral Tx May Resolve Neurologic Symptoms in HIV
Early Antiretroviral Tx May Resolve Neurologic Symptoms in HIV

HealthDay News — Neurological symptoms that present in newly infected HIV patients tend to be mild and subside after initiation of antiretroviral treatment, according to a study published in Neurology.

Among 139 people in Thailand infected with HIV 3 to 56 days before entering the study, tests revealed that 53% had neurological findings. Thirty-three percent had cognitive deficits, 34% had motor control difficulties, and 20% had neuropathy, the investigators found. Many had more than 1 symptom. One participant had Guillain-Barré syndrome, the only severe condition in the group.

All the patients were offered and began antiretroviral treatment when they were diagnosed with HIV infection. Ninety percent of the neurological symptoms had resolved after 1 month of treatment, but 9% continued to have symptoms 6 months later. The researchers also found that neurological symptoms were associated with higher mean plasma log10 HIV RNA at diagnosis.

"While the findings were mild, it is clear that HIV affects the nervous system within days of infection," study author Joanna Hellmuth, MD, a clinical fellow in the department of neurology at the University of California, San Francisco, said in a university news release. "Since the majority of these neurologic issues were resolved with treatment, our study reinforces recommendations that people at risk for HIV test often and start antiretroviral treatment immediately if they are infected."

Reference

Hellmuth J, Fletcher JL, Valcour V, et al. Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology. 2016; doi:10.1212/WNL.0000000000002837.

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