Neurodegenerative Diseases

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Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Because of dementia's prolonged disease course, advance care decisions and planning are often overlooked until it is too late.

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Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

Merck announced the discontinuation of the Phase 3 APECS study for the treatment of AD.

Tamsulosin Associated With Dementia Risk in Older Patients With BPH

Tamsulosin Associated With Dementia Risk in Older Patients With BPH

Because of the study's nonrandomized and observational design, the investigators were unable to determine any causal relationships between tamsulosin and dementia risk.

Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease

Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease

In both the cortical and subcortical gray matter and white matter, higher baseline Nfl concentrations were associated with reduced brain volume.

Premature Dementia Risk Increased in Those With Heart Defects

Premature Dementia Risk Increased in Those With Heart Defects

An increased risk of dementia is assocaited with congenital heart disease.

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

The 400 mg solanezumab dose used in this study may not have been sufficient enough to provide clinically meaningful effects in these patients.

Positive Opinions on Age May Help Ward Off Dementia

Positive Opinions on Age May Help Ward Off Dementia

Positive beliefs on age may protect against dementia.

Alzheimer Disease May Benefit From Deep Brain Stimulation

Alzheimer Disease May Benefit From Deep Brain Stimulation

The use of DBS in patients with Alzheimer disease is well tolerated and associated with less decline on the CDR-SB.

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

A study was conducted to assess potential beneficial effects of a lifestyle intervention program on cognition in carriers of the APOE ε4 allele.

Dementia Less Likely in Vision-Tested Drivers Who Crash

Dementia Less Likely in Vision-Tested Drivers Who Crash

For older adults who are hospitalized after car crashes, vision testing and renewal requirements show to be related to reduced prevalence of dementia.

Solanezumab Has No Effect on Cognitive Decline in Alzheimer Disease

Solanezumab Has No Effect on Cognitive Decline in Alzheimer Disease

Solanezumab does not alter cognitive decline in patients with mild Alzheimer disease.

Lifestyle Intervention May Improve Cognition in APOEε4 Carriers

Lifestyle Intervention May Improve Cognition in APOEε4 Carriers

In older at-risk individuals, even APOE ε4 carriers, a multidomain lifestyle intervention seems to be beneficial.

Caffeinated, Sugary Soda Consumption Associated With Early Onset of Huntington Disease

Caffeinated, Sugary Soda Consumption Associated With Early Onset of Huntington Disease

Sugar found in caffeinated soda is associated with increased systemic inflammatory processes that may in turn be associated with neurodegeneration.

Dementia With Lewy Bodies Benefits From Adjunctive Zonisamide

Dementia With Lewy Bodies Benefits From Adjunctive Zonisamide

Zonisamide as an adjunct to levodopa therapy improves parkinsonism in patients with dementia with Lewy bodies.

Alternative Genetic Risk Variant for Alzheimer Disease Identified

Alternative Genetic Risk Variant for Alzheimer Disease Identified

Brain amyloidosis is associated with certain Alzheimer disease risk variants.

No Cognitive Improvement With Idalopirdine in Mild Alzheimer Disease

No Cognitive Improvement With Idalopirdine in Mild Alzheimer Disease

For patients with mild-to-moderate Alzheimer disease, the use of idalopirdine does not improve cognition.

Risk for Cognitive Decline, Dementia Linked to Age-Related Hearing Loss

Risk for Cognitive Decline, Dementia Linked to Age-Related Hearing Loss

Clinicians might benefit from standard guidelines on how to assess and refer patients with hearing loss.

Increased Dementia Risk Seen in Rheumatic Diseases

Increased Dementia Risk Seen in Rheumatic Diseases

There is an increased risk of dementia for patients with rheumatic diseases.

Increased Midlife Triglyceride Levels Predictive of Alzheimer Disease Pathology

Increased Midlife Triglyceride Levels Predictive of Alzheimer Disease Pathology

If confirmed in future studies, high triglycerides may present a modifiable risk factor for Alzheimer disease.

Limited Evidence Supports Physical Interventions for Dementia Prevention

Limited Evidence Supports Physical Interventions for Dementia Prevention

A hanful of studies reviewed the different types of interventions to prevent late-life dementia.

Proton Pump Inhibitor Use Not Associated With Increased Dementia Risk

Proton Pump Inhibitor Use Not Associated With Increased Dementia Risk

A population-based cohort study evaluated whether proton pump inhibitor use was associated with an increased risk for dementia.

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