Neurodegenerative Diseases

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Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Because of dementia's prolonged disease course, advance care decisions and planning are often overlooked until it is too late.

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Mood Stabilizer Use Among Long-Term Care Patients Declines Following CMS Program

Mood Stabilizer Use Among Long-Term Care Patients Declines Following CMS Program

Investigators evaluated the association between initiation of the partnership and prescribing practices for antipsychotic and non-antipsychotic psychotropic medications.

Phase 3 Results Released for Investigational Alzheimer Disease Treatment

Phase 3 Results Released for Investigational Alzheimer Disease Treatment

Results showed that after 18-months, there was no significant statistical difference in cognitive or functional outcomes between those patients taking azeliragon and the placebo group.

High Amyloid Beta, Independent of Tau, Is Associated With Risk for Cognitive Decline

High Amyloid Beta, Independent of Tau, Is Associated With Risk for Cognitive Decline

Preclinical AD stages 1 and 2 demonstrated higher rates of linear cognitive decline with age, particularly with regard to story memory and processing speed measures.

Concern for Employer, Insurance Discrimination for Alzheimer's Patients

Concern for Employer, Insurance Discrimination for Alzheimer's Patients

About half of adults surveyed expect a man with mild Alzheimer dementia to be discriminated against.

Impact of Mediterranean Diet on Aging Examined

Impact of Mediterranean Diet on Aging Examined

Following a Mediterranean diet may be correlated with slowed aging.

Excessive Sleepiness Associated With Increased Aβ Accumulation in Elderly Without Dementia

Excessive Sleepiness Associated With Increased Aβ Accumulation in Elderly Without Dementia

This study predominantly relied on a subjective patient reporting system to assess sleep disturbances, which may have limited the findings.

β-amyloidosis Alone is an Unreliable Predictor of Alzheimer Disease Progression

β-amyloidosis Alone is an Unreliable Predictor of Alzheimer Disease Progression

Only 4 patients had progressed to clinical AD during the follow-up period, all of whom rated positive for amyloid β deposition.

Nurse Education Improves Post-Op Survival in Dementia Patients

Nurse Education Improves Post-Op Survival in Dementia Patients

Findings show lower post-surgical mortality among patients with Alzheimer's disease.

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

Investigators evaluated CSF Aβ1-42 levels obtained from individuals who presented no signs of cognitive dysfunction at enrollment and estimated the proximity of participants' age to their parents' age of AD symptom onset.

Dementia Risk Reduced in Women With High Midlife Cardiac Fitness

Dementia Risk Reduced in Women With High Midlife Cardiac Fitness

Women may have a reduced risk of subsequent dementia with higher cardiovascular fitness at midlife.

Frontotemporal Dementia, Frontotemporal Lobar Degeneration Symptoms More Common Later in Life

Frontotemporal Dementia, Frontotemporal Lobar Degeneration Symptoms More Common Later in Life

The investigators hope that the findings from the study help raise awareness of frontotemporal dementia in geriatric patients.

Alcohol Use Disorders Associated With Early-Onset Dementia

Alcohol Use Disorders Associated With Early-Onset Dementia

Among 5.2% of cases of early-onset dementia, most were either alcohol-related by definition or had an additional diagnosis of alcohol use disorders.

Program Helps Improve Communication Among Couples Affected by Dementia

Program Helps Improve Communication Among Couples Affected by Dementia

Spouses affected by dementia may benefit from an at-home dyadic, relationship-focused psychoeducational intervention.

Long-Term Forgetting May Identify Alzheimer Disease Symptoms Before Onset

Long-Term Forgetting May Identify Alzheimer Disease Symptoms Before Onset

The investigators assessed the amount of material retained at 30 minutes and compared this with material recalled at 7 days.

Short-Term Benefit for Alzheimer Disease Psychosis With Pimavanserin

Short-Term Benefit for Alzheimer Disease Psychosis With Pimavanserin

Despite its short-term efficacy, pimavanserin provided no significant benefit in the overall cohort for improving psychotic symptoms at 12 weeks of treatment when compared with placebo.

Preclinical Alzheimer's Identified With Molecular Markers

Preclinical Alzheimer's Identified With Molecular Markers

Molecular markers can identify changes associated with the disease before clinical onset for young adults with autosomal dominant AD.

Tau PET a Useful Biomarker for Alzheimer Disease Risk and Progression

Tau PET a Useful Biomarker for Alzheimer Disease Risk and Progression

PET imaging may help clinicians track progression of the disease and evaluate response to disease-modifying treatments.

Investigators Discover Efficient Plasma Biomarkers for Predicting Amyloid-β Burden in Dementia

Investigators Discover Efficient Plasma Biomarkers for Predicting Amyloid-β Burden in Dementia

Accuracy of the composite biomarker for predicting brain amyloid-β burden was 90% with the use of 11C-labelled Pittsburgh compound-B-PET as a standard of truth.

Amyloid Deposition May Be Reversed With BACE1 Inhibition

Amyloid Deposition May Be Reversed With BACE1 Inhibition

Sequential, increased deletion of BACE1 in an adult mouse model of Alzheimer disease reversed amyloid deposition.

Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

Merck announced the discontinuation of the Phase 3 APECS study for the treatment of AD.

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