Neurodegenerative Diseases

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Pseudobulbar Affect: Signs, Symptoms, and Treatment for Uncontrollable Laughing or Crying

Pseudobulbar Affect: Signs, Symptoms, and Treatment for Uncontrollable Laughing or Crying

Pseudobulbar affect is a significant national health issue in the United States, with approximately 2 million individuals affected.

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Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

Investigators evaluated cognition with measures reflecting executive function, episodic memory, semantic fluency, and processing speed on an annual basis.

Positive Link Between Air Pollution, Diagnosis of Dementia

Positive Link Between Air Pollution, Diagnosis of Dementia

There is a positive association between residential levels of air pollution and being diagnosed with dementia.

Age, Sex, APOE Genotype Identify Alzheimer's, Dementia Risk

Age, Sex, APOE Genotype Identify Alzheimer's, Dementia Risk

Age, sex and apolipoprotein E genotype can identify groups at high 10-year risk for Alzheimer disease and all dementia.

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple pathways account for the age-related increases in dementia risk.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

The burden of Alzheimer disease and related dementias is expected to increase to 3.3% in the United States by 2060.

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer disease.

Late-Life Blood Pressure Associated With Alzheimer Disease Brain Pathology

Late-Life Blood Pressure Associated With Alzheimer Disease Brain Pathology

Patients with a higher mean systolic blood pressure during follow-up had increased odds for brain infarcts compared with those with lower levels.

Low Fasting Insulin Associated With Long-Term Dementia Risk

Low Fasting Insulin Associated With Long-Term Dementia Risk

Having high insulin at baseline was associated with a greater risk for incident diabetes mellitus compared with low insulin values.

Cardiovascular Health Tied to Dementia Risk in Older Adults

Cardiovascular Health Tied to Dementia Risk in Older Adults

For older adults, increased numbers of optimal cardiovascular health metrics are associated with reduced risk of dementia.

VAT Score Improves Predictive Value of MMSE for Dementia

VAT Score Improves Predictive Value of MMSE for Dementia

Administering the Visual Association Test improves the predictive value of the Mini-Mental State Examination score for dementia.

Both Abstinence and High Alcohol Use Linked to Dementia

Both Abstinence and High Alcohol Use Linked to Dementia

Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.

Tau Associated With Loss of Anterior Temporal White Matter Integrity

Tau Associated With Loss of Anterior Temporal White Matter Integrity

Tau was found to be a significant predictor of mean diffusivity in the anterior temporal white matter.

Monoclonal Antibody Granted Orphan Drug Status for Frontotemporal Dementia

Monoclonal Antibody Granted Orphan Drug Status for Frontotemporal Dementia

There are currently no treatments available for frontotemporal dementia.

PET Imaging Can Measure Synaptic Loss From Alzheimer's

PET Imaging Can Measure Synaptic Loss From Alzheimer's

Positron emission tomographic imaging can directly measure synaptic loss with Alzheimer disease.

Confabulations Linked to Impaired Mental Time Travel in Alzheimer Disease

Confabulations Linked to Impaired Mental Time Travel in Alzheimer Disease

The findings suggest that confabulations by patients with AD are related to an impaired ability to mentally go back in time to retrieve the context in which the confabulated memories were encoded.

Link Between Lower Cognitive Ability in Young Adults and Risk for Dementia

Link Between Lower Cognitive Ability in Young Adults and Risk for Dementia

Lower cognitive ability total and verbal ability scores were predictive of greater risk for early-onset dementia.

Treatment for Alzheimer-Related Agitation Gets Fast Track Status

Treatment for Alzheimer-Related Agitation Gets Fast Track Status

Currently, there are no approved treatments for behavioral symptoms in Alzheimer disease.

Midlife Cognition, Vascular Health Predict Dementia and Cognitive Impairment Later in Life

Midlife Cognition, Vascular Health Predict Dementia and Cognitive Impairment Later in Life

Investigators reviewed data from patients aged 45 to 64 years who were enrolled in the Atherosclerosis Risk in Communities Study and who attended additional visits for cognitive function evaluation and repeat cardiovascular risk factor assessment.

Positive PET Results and Hippocampal Volume Predict Progression From MCI to Dementia

Positive PET Results and Hippocampal Volume Predict Progression From MCI to Dementia

An international team of investigators assessed the ability of flutemetamol F 18-labeled PET and other biomarkers to predict risk of clinical progression from amnestic mild cognitive impairment to probable Alzheimer disease.

HTT CAG Repeat Size, Age at Onset Associated With Huntington Disease Progression

HTT CAG Repeat Size, Age at Onset Associated With Huntington Disease Progression

Investigators sought to assess factors contributing to progression of functional, cognitive, and motor impairment in Huntington disease.

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