Neurodegenerative Diseases

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Critical Illness and the Brain: Managing Risk for Cognitive Adverse Effects

Critical Illness and the Brain: Managing Risk for Cognitive Adverse Effects

The results highlight the importance of evaluating and monitoring cognitive function in individuals with recent critical illness or major infections, especially if they are already at risk for dementia.

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Autoimmune Diseases Increase Hippocampal Sclerosis Risk in Nonagenarians

Autoimmune Diseases Increase Hippocampal Sclerosis Risk in Nonagenarians

The mean duration of dementia was longer among individuals with hippocampal sclerosis vs those without.

Hearing Loss in Older Adults Linked to Depression, Dementia Among Other Comorbidities

Hearing Loss in Older Adults Linked to Depression, Dementia Among Other Comorbidities

Hearing loss affects more than 50% of Americans 60 years or older.

Neurofilament Light Biomarkers Identify Alzheimer Disease Risk in Down Syndrome

Neurofilament Light Biomarkers Identify Alzheimer Disease Risk in Down Syndrome

Investigators analyzed the diagnostic performance of plasma cerebrospinal fluid and neurofilament light biomarkers in patients with Down syndrome and Alzheimer disease.

Dominantly Inherited Alzheimer Disease: Cognitive and Biomarker Changes

Dominantly Inherited Alzheimer Disease: Cognitive and Biomarker Changes

Investigators examined the onset, sequence, and rate of progression of biomarker and clinical measures across the spectrum of Alzheimer disease, using the Dominantly Inherited Alzheimer Network study.

PET Scans Distinguish Alzheimer Disease From Other Neurodegenerative Diseases

PET Scans Distinguish Alzheimer Disease From Other Neurodegenerative Diseases

The use of positron emission tomography was able to discriminate between Alzheimer disease and other neurodegenerative disorders in a multicenter, cross-sectional study conducted at 3 dementia centers in South Korea, Sweden, and the United States.

Dementia Tied to Mortality in Older Adults With Down Syndrome

Dementia Tied to Mortality in Older Adults With Down Syndrome

Dementia is associated with mortality in most older adults with Down syndrome.

Smoking Identified as an Independent Risk Factor for Dementia

Smoking Identified as an Independent Risk Factor for Dementia

Investigators examined the effect smoking has on the risk for dementia using a nationwide health claims database in Korea.

18F-FDG PET Algorithm Allows Early Prediction of Alzheimer's

18F-FDG PET Algorithm Allows Early Prediction of Alzheimer's

Fluorine 18 fluorodeoxyglucose PET of the brain can be used to develop a deep learning algorithm for early prediction of AD that has high specificity and sensitivity.

Abnormalities in Genes Linked to IRSP in Alzheimer Disease

Abnormalities in Genes Linked to IRSP in Alzheimer Disease

Individuals with Alzheimer disease have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway.

Alzheimer Disease Biomarkers Expose Individuals to Long-Term Care Insurance Denial

Alzheimer Disease Biomarkers Expose Individuals to Long-Term Care Insurance Denial

Approximately 5.5 million Americans have Alzheimer disease or dementia.

Preeclampsia Tied to Increased Risk for Vascular Dementia

Preeclampsia Tied to Increased Risk for Vascular Dementia

Preeclampsia seems to be associated with an increased risk for dementia, especially vascular dementia, with a stronger correlation for late-onset disease.

Biomarkers of Alzheimer Disease Observed in Down Syndrome

Biomarkers of Alzheimer Disease Observed in Down Syndrome

Neurological and neuropsychological examinations were performed to assess intellectual disabilities, and biological assays were performed on collected CSF and plasma.

Multiple Births Associated With Greater Late-Life Risk for Alzheimer Disease

Multiple Births Associated With Greater Late-Life Risk for Alzheimer Disease

Grand multiparity was associated with significantly worse Mini-Mental State Examination scores compared with those with 1 to 4 completed pregnancies.

Atrial Fibrillation Tied to Higher Dementia Risk in Older Adults

Atrial Fibrillation Tied to Higher Dementia Risk in Older Adults

Atrial fibrillation is associated with a faster global cognitive decline and an increased risk for dementia in older people.

Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

Investigators evaluated cognition with measures reflecting executive function, episodic memory, semantic fluency, and processing speed on an annual basis.

Positive Link Between Air Pollution, Diagnosis of Dementia

Positive Link Between Air Pollution, Diagnosis of Dementia

There is a positive association between residential levels of air pollution and being diagnosed with dementia.

Age, Sex, APOE Genotype Identify Alzheimer's, Dementia Risk

Age, Sex, APOE Genotype Identify Alzheimer's, Dementia Risk

Age, sex and apolipoprotein E genotype can identify groups at high 10-year risk for Alzheimer disease and all dementia.

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple pathways account for the age-related increases in dementia risk.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

The burden of Alzheimer disease and related dementias is expected to increase to 3.3% in the United States by 2060.

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer disease.

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