Neurodegenerative Diseases

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Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Because of dementia's prolonged disease course, advance care decisions and planning are often overlooked until it is too late.

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Lifestyle, Behavioral Factors Contribute to Dementia Risk Assessment

Lifestyle, Behavioral Factors Contribute to Dementia Risk Assessment

Decision tree and random forest classification models were used to find associations between patient demographic and lifestyle risk factors with dementia status during more than 30 years of follow-up.

Salivary Levels of Total Huntington Protein Promising as Biomarker for Huntington Disease

Salivary Levels of Total Huntington Protein Promising as Biomarker for Huntington Disease

Measurement of the disease protein huntingtin in saliva may be promising as an accessible, noninvasive biomarker to predict symptom severity and disease course in individuals with Huntington disease.

Trials for Investigational Alzheimer's Tx Lanabecestat Discontinued

Trials for Investigational Alzheimer's Tx Lanabecestat Discontinued

Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.

Higher Blood Pressure at Mid-Life Increases Dementia Risk

Higher Blood Pressure at Mid-Life Increases Dementia Risk

The risk of dementia is increased in 50-year-olds with blood pressure ≥130 mm Hg, which is below the current threshold for hypertension.

Intellectual Activities in Later Life May Cut Dementia Risk

Intellectual Activities in Later Life May Cut Dementia Risk

Active participation in intellectual activities among adults aged 65 years or older is associated with reduced risk of dementia.

Visual Association Test, MMSE Highly Predictive of Dementia in Older Adults

Visual Association Test, MMSE Highly Predictive of Dementia in Older Adults

Using the Visual Association Test along with the Mini Mental State Examination may improve predictive value to screen for cognitive deficits.

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.

GRN Mutations May Modify Risk for Frontotemporal Lobar Degeneration

GRN Mutations May Modify Risk for Frontotemporal Lobar Degeneration

In the discovery stage, genome-wide and logistic and linear regression analyses were performed to examine the association of genetic variants with risk for disease and age at onset in those with a GRN mutation and controls who were free of neurodegenerative disorders.

APOE Status May Modulate Neurodegeneration Risk Based on Sex

APOE Status May Modulate Neurodegeneration Risk Based on Sex

The investigators analyzed specific AD biomarkers, including β-amyloid 42, total tau, and phosphorylated tau measured in CSF.

Polyphenol-Rich Diet May Reduce Dementia Risk in Older Adults

Polyphenol-Rich Diet May Reduce Dementia Risk in Older Adults

There was an observable pattern with combined polyphenol intake and risk for dementia in the study cohort.

Studies Halted for Alzheimer's Candidate Atabecestat Due to Safety Concerns

Studies Halted for Alzheimer's Candidate Atabecestat Due to Safety Concerns

Janssen announced that the Company will no longer continue studying atabecestat, an investigational treatment for asymptomatic patients at risk for developing Alzheimer disease.

Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

The findings from the study are limited in generalizability to the dementia-free patient population.

Risk of Dementia Up for Older Adults With Lowest Wealth

Risk of Dementia Up for Older Adults With Lowest Wealth

Researchers examined the correlation of education, wealth, and area-based deprivation with the incidence of dementia using data from the English Longitudinal Study of Ageing.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

These results suggest that antipsychotic exposure has no impact on relative mortality.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

An aerobic and strength exercise program does not slow cognitive impairment among people with mild-to-moderate dementia.

Study IDs Factors Linked to Quality of Life With Dementia

Study IDs Factors Linked to Quality of Life With Dementia

Good relationships, social engagement, and high-quality care are linked to better QoL for patients with dementia.

Depressive Symptoms Tied to Memory, Aging of the Brain

Depressive Symptoms Tied to Memory, Aging of the Brain

Greater depressive symptoms are associated with episodic memory and markers of brain aging in older Caribbean Hispanic patients.

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

Methylphenidate demonstrated an improvement in apathy vs placebo when measured by the apathy evaluation scale, in addition, methylphenidate showed possible improvement in cognition.

Approaches to Firearms for Persons With Dementia Discussed

Approaches to Firearms for Persons With Dementia Discussed

Approaches to guns for patients with mild cognitive impairment could be similar to those for driving.

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