Neurodegenerative Diseases

Mood Stabilizer Use Among Long-Term Care Patients Declines Following CMS Program

Mood Stabilizer Use Among Long-Term Care Patients Declines Following CMS Program

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Investigators evaluated the association between initiation of the partnership and prescribing practices for antipsychotic and non-antipsychotic psychotropic medications.

Phase 3 Results Released for Investigational Alzheimer Disease Treatment

Phase 3 Results Released for Investigational Alzheimer Disease Treatment

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Results showed that after 18-months, there was no significant statistical difference in cognitive or functional outcomes between those patients taking azeliragon and the placebo group.

High Amyloid Beta, Independent of Tau, Is Associated With Risk for Cognitive Decline

High Amyloid Beta, Independent of Tau, Is Associated With Risk for Cognitive Decline

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Preclinical AD stages 1 and 2 demonstrated higher rates of linear cognitive decline with age, particularly with regard to story memory and processing speed measures.

Concern for Employer, Insurance Discrimination for Alzheimer's Patients

Concern for Employer, Insurance Discrimination for Alzheimer's Patients

About half of adults surveyed expect a man with mild Alzheimer dementia to be discriminated against.

Impact of Mediterranean Diet on Aging Examined

Impact of Mediterranean Diet on Aging Examined

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Following a Mediterranean diet may be correlated with slowed aging.

Excessive Sleepiness Associated With Increased Aβ Accumulation in Elderly Without Dementia

Excessive Sleepiness Associated With Increased Aβ Accumulation in Elderly Without Dementia

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This study predominantly relied on a subjective patient reporting system to assess sleep disturbances, which may have limited the findings.

β-amyloidosis Alone is an Unreliable Predictor of Alzheimer Disease Progression

β-amyloidosis Alone is an Unreliable Predictor of Alzheimer Disease Progression

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Only 4 patients had progressed to clinical AD during the follow-up period, all of whom rated positive for amyloid β deposition.

Nurse Education Improves Post-Op Survival in Dementia Patients

Nurse Education Improves Post-Op Survival in Dementia Patients

Findings show lower post-surgical mortality among patients with Alzheimer's disease.

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

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Investigators evaluated CSF Aβ1-42 levels obtained from individuals who presented no signs of cognitive dysfunction at enrollment and estimated the proximity of participants' age to their parents' age of AD symptom onset.

Dementia Risk Reduced in Women With High Midlife Cardiac Fitness

Dementia Risk Reduced in Women With High Midlife Cardiac Fitness

Women may have a reduced risk of subsequent dementia with higher cardiovascular fitness at midlife.

Frontotemporal Dementia, Frontotemporal Lobar Degeneration Symptoms More Common Later in Life

Frontotemporal Dementia, Frontotemporal Lobar Degeneration Symptoms More Common Later in Life

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The investigators hope that the findings from the study help raise awareness of frontotemporal dementia in geriatric patients.

Prevalence of ALS Remains Steady in US

Prevalence of ALS Remains Steady in US

The prevalence of ALS in the United States has been steady.

Alcohol Use Disorders Associated With Early-Onset Dementia

Alcohol Use Disorders Associated With Early-Onset Dementia

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Among 5.2% of cases of early-onset dementia, most were either alcohol-related by definition or had an additional diagnosis of alcohol use disorders.

Program Helps Improve Communication Among Couples Affected by Dementia

Program Helps Improve Communication Among Couples Affected by Dementia

Spouses affected by dementia may benefit from an at-home dyadic, relationship-focused psychoeducational intervention.

Long-Term Forgetting May Identify Alzheimer Disease Symptoms Before Onset

Long-Term Forgetting May Identify Alzheimer Disease Symptoms Before Onset

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The investigators assessed the amount of material retained at 30 minutes and compared this with material recalled at 7 days.

Short-Term Benefit for Alzheimer Disease Psychosis With Pimavanserin

Short-Term Benefit for Alzheimer Disease Psychosis With Pimavanserin

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Despite its short-term efficacy, pimavanserin provided no significant benefit in the overall cohort for improving psychotic symptoms at 12 weeks of treatment when compared with placebo.

Preclinical Alzheimer's Identified With Molecular Markers

Preclinical Alzheimer's Identified With Molecular Markers

Molecular markers can identify changes associated with the disease before clinical onset for young adults with autosomal dominant AD.

Cognition Influenced by Cardiorespiratory Fitness, White Matter Integrity

Cognition Influenced by Cardiorespiratory Fitness, White Matter Integrity

In patients with mild cognitive impairment, CRF is associated with better white matter fiber integrity.

Tau PET a Useful Biomarker for Alzheimer Disease Risk and Progression

Tau PET a Useful Biomarker for Alzheimer Disease Risk and Progression

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PET imaging may help clinicians track progression of the disease and evaluate response to disease-modifying treatments.

Investigators Discover Efficient Plasma Biomarkers for Predicting Amyloid-β Burden in Dementia

Investigators Discover Efficient Plasma Biomarkers for Predicting Amyloid-β Burden in Dementia

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Accuracy of the composite biomarker for predicting brain amyloid-β burden was 90% with the use of 11C-labelled Pittsburgh compound-B-PET as a standard of truth.

Amyloid Deposition May Be Reversed With <i>BACE1</i> Inhibition

Amyloid Deposition May Be Reversed With BACE1 Inhibition

Sequential, increased deletion of BACE1 in an adult mouse model of Alzheimer disease reversed amyloid deposition.

Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

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Merck announced the discontinuation of the Phase 3 APECS study for the treatment of AD.

Tamsulosin Associated With Dementia Risk in Older Patients With BPH

Tamsulosin Associated With Dementia Risk in Older Patients With BPH

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Because of the study's nonrandomized and observational design, the investigators were unable to determine any causal relationships between tamsulosin and dementia risk.

Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease

Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease

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In both the cortical and subcortical gray matter and white matter, higher baseline Nfl concentrations were associated with reduced brain volume.

Premature Dementia Risk Increased in Those With Heart Defects

Premature Dementia Risk Increased in Those With Heart Defects

An increased risk of dementia is assocaited with congenital heart disease.

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

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The 400 mg solanezumab dose used in this study may not have been sufficient enough to provide clinically meaningful effects in these patients.

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

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Investigators sought to examine factors that influence a cognitively normal individual's risk for developing symptoms of mild cognitive impairment due to Alzheimer disease.

Positive Opinions on Age May Help Ward Off Dementia

Positive Opinions on Age May Help Ward Off Dementia

Positive beliefs on age may protect against dementia.

Alzheimer Disease May Benefit From Deep Brain Stimulation

Alzheimer Disease May Benefit From Deep Brain Stimulation

The use of DBS in patients with Alzheimer disease is well tolerated and associated with less decline on the CDR-SB.

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

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A study was conducted to assess potential beneficial effects of a lifestyle intervention program on cognition in carriers of the APOE ε4 allele.

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