Decision tree and random forest classification models were used to find associations between patient demographic and lifestyle risk factors with dementia status during more than 30 years of follow-up.
Measurement of the disease protein huntingtin in saliva may be promising as an accessible, noninvasive biomarker to predict symptom severity and disease course in individuals with Huntington disease.
Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.
The risk of dementia is increased in 50-year-olds with blood pressure ≥130 mm Hg, which is below the current threshold for hypertension.
Active participation in intellectual activities among adults aged 65 years or older is associated with reduced risk of dementia.
Using the Visual Association Test along with the Mini Mental State Examination may improve predictive value to screen for cognitive deficits.
The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.
In the discovery stage, genome-wide and logistic and linear regression analyses were performed to examine the association of genetic variants with risk for disease and age at onset in those with a GRN mutation and controls who were free of neurodegenerative disorders.
Brain autopsies of participants of the Rush Memory Aging project (n=428) were studied to identify the association between brain pathologies and total daily physical activity and mortality.
The investigators analyzed specific AD biomarkers, including β-amyloid 42, total tau, and phosphorylated tau measured in CSF.
There was an observable pattern with combined polyphenol intake and risk for dementia in the study cohort.
There was a shorter mean time from the index date to the dementia diagnosis among those with traumatic brain injury vs those without traumatic brain injury.
Janssen announced that the Company will no longer continue studying atabecestat, an investigational treatment for asymptomatic patients at risk for developing Alzheimer disease.
The findings from the study are limited in generalizability to the dementia-free patient population.
Researchers examined the correlation of education, wealth, and area-based deprivation with the incidence of dementia using data from the English Longitudinal Study of Ageing.
These results suggest that antipsychotic exposure has no impact on relative mortality.
Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.
An aerobic and strength exercise program does not slow cognitive impairment among people with mild-to-moderate dementia.
Good relationships, social engagement, and high-quality care are linked to better QoL for patients with dementia.
Methylphenidate demonstrated an improvement in apathy vs placebo when measured by the apathy evaluation scale, in addition, methylphenidate showed possible improvement in cognition.
Approaches to guns for patients with mild cognitive impairment could be similar to those for driving.
For persons with dementia, the DRESS prototype, can provide automated dressing support by identifying incorrect dressing scenarios.
Clinically significant anxiety in midlife is associated with increased subsequent dementia risk over an interval of at least 10 years.
The combination of a rural upbringing and higher education levels may be protective against dementia and Alzheimer disease for African-Americans.
Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative SyndromesMay 10, 2018
Individual patients with PCA and LDs demonstrated more right-lateralized patterns of atrophy and greater preservation of global cognition compared with patients with PCA without LDs.
Use of anticholinergic drugs may be tied to a future diagnosis of dementia.
For nursing home residents with dementia and hip fracture, surgical hip fracture repair is associated with lower mortality.
There is a linear correlation for physical activity with amyotrophic lateral sclerosis.
Controlling high blood pressure in older African-Americans may prevent future dementia.
Investigators sought to identify genetic factors that may contribute to the risk for neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.
Neurology Advisor Articles
- Efficacy of Cladribine Tablets in Patients With Relapsing Multiple Sclerosis
- Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine
- Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease
- FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease
- Shortened MS Quality-of-Life Questionnaire Compares With Longer Test in Reliability and Consistency
- Polyphenol-Rich Diet May Reduce Dementia Risk in Older Adults
- Addressing Migraine That Mimics Stroke
- Visual Association Test, MMSE Highly Predictive of Dementia in Older Adults
- Prediction Algorithm Stratifies ICH Patients at Risk for Hematoma Expansion
- Medical Cannabis Shows Promise in Treating Symptoms of Multiple Sclerosis
- Rituximab Effectively Reduces Disease Activity in Multiple Sclerosis
- Characteristics, Treatment Response Similar in Idiopathic, 22q11.2 Deletion Syndrome-Associated Parkinson Disease
- Lifestyle, Behavioral Factors Contribute to Dementia Risk Assessment
- FDA Lifts Clinical Hold on Trial for Duchenne Muscular Dystrophy Treatment
- Fremanezumab Chronic Cluster Headache Study Discontinued