Neurodegenerative Diseases

Lifestyle, Behavioral Factors Contribute to Dementia Risk Assessment

Lifestyle, Behavioral Factors Contribute to Dementia Risk Assessment

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Decision tree and random forest classification models were used to find associations between patient demographic and lifestyle risk factors with dementia status during more than 30 years of follow-up.

Salivary Levels of Total Huntington Protein Promising as Biomarker for Huntington Disease

Salivary Levels of Total Huntington Protein Promising as Biomarker for Huntington Disease

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Measurement of the disease protein huntingtin in saliva may be promising as an accessible, noninvasive biomarker to predict symptom severity and disease course in individuals with Huntington disease.

Trials for Investigational Alzheimer's Tx Lanabecestat Discontinued

Trials for Investigational Alzheimer's Tx Lanabecestat Discontinued

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Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.

Higher Blood Pressure at Mid-Life Increases Dementia Risk

Higher Blood Pressure at Mid-Life Increases Dementia Risk

The risk of dementia is increased in 50-year-olds with blood pressure ≥130 mm Hg, which is below the current threshold for hypertension.

Intellectual Activities in Later Life May Cut Dementia Risk

Intellectual Activities in Later Life May Cut Dementia Risk

Active participation in intellectual activities among adults aged 65 years or older is associated with reduced risk of dementia.

Visual Association Test, MMSE Highly Predictive of Dementia in Older Adults

Visual Association Test, MMSE Highly Predictive of Dementia in Older Adults

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Using the Visual Association Test along with the Mini Mental State Examination may improve predictive value to screen for cognitive deficits.

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.

<i>GRN</i> Mutations May Modify Risk for Frontotemporal Lobar Degeneration

GRN Mutations May Modify Risk for Frontotemporal Lobar Degeneration

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In the discovery stage, genome-wide and logistic and linear regression analyses were performed to examine the association of genetic variants with risk for disease and age at onset in those with a GRN mutation and controls who were free of neurodegenerative disorders.

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

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Brain autopsies of participants of the Rush Memory Aging project (n=428) were studied to identify the association between brain pathologies and total daily physical activity and mortality.

<i>APOE</i> Status May Modulate Neurodegeneration Risk Based on Sex

APOE Status May Modulate Neurodegeneration Risk Based on Sex

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The investigators analyzed specific AD biomarkers, including β-amyloid 42, total tau, and phosphorylated tau measured in CSF.

Polyphenol-Rich Diet May Reduce Dementia Risk in Older Adults

Polyphenol-Rich Diet May Reduce Dementia Risk in Older Adults

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There was an observable pattern with combined polyphenol intake and risk for dementia in the study cohort.

Traumatic Brain Injury Without Loss of Consciousness Associated With Increased Dementia Risk

Traumatic Brain Injury Without Loss of Consciousness Associated With Increased Dementia Risk

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There was a shorter mean time from the index date to the dementia diagnosis among those with traumatic brain injury vs those without traumatic brain injury.

Studies Halted for Alzheimer's Candidate Atabecestat Due to Safety Concerns

Studies Halted for Alzheimer's Candidate Atabecestat Due to Safety Concerns

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Janssen announced that the Company will no longer continue studying atabecestat, an investigational treatment for asymptomatic patients at risk for developing Alzheimer disease.

Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

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The findings from the study are limited in generalizability to the dementia-free patient population.

Risk of Dementia Up for Older Adults With Lowest Wealth

Risk of Dementia Up for Older Adults With Lowest Wealth

Researchers examined the correlation of education, wealth, and area-based deprivation with the incidence of dementia using data from the English Longitudinal Study of Ageing.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

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Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

An aerobic and strength exercise program does not slow cognitive impairment among people with mild-to-moderate dementia.

Study IDs Factors Linked to Quality of Life With Dementia

Study IDs Factors Linked to Quality of Life With Dementia

Good relationships, social engagement, and high-quality care are linked to better QoL for patients with dementia.

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

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Methylphenidate demonstrated an improvement in apathy vs placebo when measured by the apathy evaluation scale, in addition, methylphenidate showed possible improvement in cognition.

Approaches to Firearms for Persons With Dementia Discussed

Approaches to Firearms for Persons With Dementia Discussed

Approaches to guns for patients with mild cognitive impairment could be similar to those for driving.

DRESS Prototype Promising for Persons With Dementia

DRESS Prototype Promising for Persons With Dementia

For persons with dementia, the DRESS prototype, can provide automated dressing support by identifying incorrect dressing scenarios.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically significant anxiety in midlife is associated with increased subsequent dementia risk over an interval of at least 10 years.

Rural Childhood, Higher Education Cuts Later Life Dementia Risk

Rural Childhood, Higher Education Cuts Later Life Dementia Risk

The combination of a rural upbringing and higher education levels may be protective against dementia and Alzheimer disease for African-Americans.

Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative Syndromes

Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative Syndromes

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Individual patients with PCA and LDs demonstrated more right-lateralized patterns of atrophy and greater preservation of global cognition compared with patients with PCA without LDs.

Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Use of anticholinergic drugs may be tied to a future diagnosis of dementia.

Surgery for Hip Fx Cuts Mortality in NH Residents With Dementia

Surgery for Hip Fx Cuts Mortality in NH Residents With Dementia

For nursing home residents with dementia and hip fracture, surgical hip fracture repair is associated with lower mortality.

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

There is a linear correlation for physical activity with amyotrophic lateral sclerosis.

Controlling High Blood Pressure Could Prevent Dementia

Controlling High Blood Pressure Could Prevent Dementia

Controlling high blood pressure in older African-Americans may prevent future dementia.

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

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Investigators sought to identify genetic factors that may contribute to the risk for neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.

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