Neurodegenerative Diseases

Hearing Loss in Older Adults Linked to Depression, Dementia Among Other Comorbidities

Hearing Loss in Older Adults Linked to Depression, Dementia Among Other Comorbidities

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Hearing loss affects more than 50% of Americans 60 years or older.

Neurofilament Light Biomarkers Identify Alzheimer Disease Risk in Down Syndrome

Neurofilament Light Biomarkers Identify Alzheimer Disease Risk in Down Syndrome

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Investigators analyzed the diagnostic performance of plasma cerebrospinal fluid and neurofilament light biomarkers in patients with Down syndrome and Alzheimer disease.

Researchers Identify Amyloid-β Pathology in Several Primary Progressive Aphasia Variants

Researchers Identify Amyloid-β Pathology in Several Primary Progressive Aphasia Variants

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Primary progressive aphasia (PPA) classification system suggests that age and apolipoprotein E genotype should be taken into account when interpreting β biomarkers in PPA.

PET Scans Distinguish Alzheimer Disease From Other Neurodegenerative Diseases

PET Scans Distinguish Alzheimer Disease From Other Neurodegenerative Diseases

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The use of positron emission tomography was able to discriminate between Alzheimer disease and other neurodegenerative disorders in a multicenter, cross-sectional study conducted at 3 dementia centers in South Korea, Sweden, and the United States.

Dementia Tied to Mortality in Older Adults With Down Syndrome

Dementia Tied to Mortality in Older Adults With Down Syndrome

Dementia is associated with mortality in most older adults with Down syndrome.

Smoking Identified as an Independent Risk Factor for Dementia

Smoking Identified as an Independent Risk Factor for Dementia

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Investigators examined the effect smoking has on the risk for dementia using a nationwide health claims database in Korea.

Quick Take: Pre-eclampsia and risk of dementia later in life: nationwide cohort study

Pre-eclampsia is defined as new onset hypertension accompanied by signs of organ dysfunction in the setting of pregnancy.

Abnormalities in Genes Linked to IRSP in Alzheimer Disease

Abnormalities in Genes Linked to IRSP in Alzheimer Disease

Individuals with Alzheimer disease have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway.

Alzheimer Disease Biomarkers Expose Individuals to Long-Term Care Insurance Denial

Alzheimer Disease Biomarkers Expose Individuals to Long-Term Care Insurance Denial

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Approximately 5.5 million Americans have Alzheimer disease or dementia.

Critical Illness and the Brain: Managing Risk for Cognitive Adverse Effects

Critical Illness and the Brain: Managing Risk for Cognitive Adverse Effects

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The results highlight the importance of evaluating and monitoring cognitive function in individuals with recent critical illness or major infections, especially if they are already at risk for dementia.

Preeclampsia Tied to Increased Risk for Vascular Dementia

Preeclampsia Tied to Increased Risk for Vascular Dementia

Preeclampsia seems to be associated with an increased risk for dementia, especially vascular dementia, with a stronger correlation for late-onset disease.

Biomarkers of Alzheimer Disease Observed in Down Syndrome

Biomarkers of Alzheimer Disease Observed in Down Syndrome

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Neurological and neuropsychological examinations were performed to assess intellectual disabilities, and biological assays were performed on collected CSF and plasma.

Multiple Births Associated With Greater Late-Life Risk for Alzheimer Disease

Multiple Births Associated With Greater Late-Life Risk for Alzheimer Disease

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Grand multiparity was associated with significantly worse Mini-Mental State Examination scores compared with those with 1 to 4 completed pregnancies.

Tiglutik Now Available for the Treatment of Amyotrophic Lateral Sclerosis

Tiglutik Now Available for the Treatment of Amyotrophic Lateral Sclerosis

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Tiglutik is supplied as a thickened riluzole liquid that is intended to ease administration for patients with dysphagia.

Modifiable CV Risk Factors Within Healthy Range Indicative of CV Morphology, White Matter Lesions

Modifiable CV Risk Factors Within Healthy Range Indicative of CV Morphology, White Matter Lesions

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In multivariable models, associations were observed between cardiovascular risk factors and cerebrovascular morphology, as well as white matter hyperintensity count.

Atrial Fibrillation Tied to Higher Dementia Risk in Older Adults

Atrial Fibrillation Tied to Higher Dementia Risk in Older Adults

Atrial fibrillation is associated with a faster global cognitive decline and an increased risk for dementia in older people.

PET imaging of tau may help distinguish Alzheimer Disease from other neurodegenerative disorders

In this cross-sectional study, the tau marker [18F]flortaucipir accurately distinguished Alzheimer's Disease dementia from other non-AD neurodegenerative disorders about 90% of the time.

Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

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Investigators evaluated cognition with measures reflecting executive function, episodic memory, semantic fluency, and processing speed on an annual basis.

Positive Link Between Air Pollution, Diagnosis of Dementia

Positive Link Between Air Pollution, Diagnosis of Dementia

There is a positive association between residential levels of air pollution and being diagnosed with dementia.

Age, Sex, <i>APOE</i> Genotype Identify Alzheimer's, Dementia Risk

Age, Sex, APOE Genotype Identify Alzheimer's, Dementia Risk

Age, sex and apolipoprotein E genotype can identify groups at high 10-year risk for Alzheimer disease and all dementia.

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple pathways account for the age-related increases in dementia risk.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

The burden of Alzheimer disease and related dementias is expected to increase to 3.3% in the United States by 2060.

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

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Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.

Improved cardiovascular health associated with lower incidence of dementia in older adults

In this prospective cohort study, older patients with more optimal cardiovascular health metrics had a lower rate of developing dementia in a dose-dependent manner.

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer disease.

Pseudobulbar Affect: Signs, Symptoms, and Treatment for Uncontrollable Laughing or Crying

Pseudobulbar Affect: Signs, Symptoms, and Treatment for Uncontrollable Laughing or Crying

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Pseudobulbar affect is a significant national health issue in the United States, with approximately 2 million individuals affected.

Late-Life Blood Pressure Associated With Alzheimer Disease Brain Pathology

Late-Life Blood Pressure Associated With Alzheimer Disease Brain Pathology

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Patients with a higher mean systolic blood pressure during follow-up had increased odds for brain infarcts compared with those with lower levels.

Low Fasting Insulin Associated With Long-Term Dementia Risk

Low Fasting Insulin Associated With Long-Term Dementia Risk

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Having high insulin at baseline was associated with a greater risk for incident diabetes mellitus compared with low insulin values.

Cardiovascular Health Tied to Dementia Risk in Older Adults

Cardiovascular Health Tied to Dementia Risk in Older Adults

For older adults, increased numbers of optimal cardiovascular health metrics are associated with reduced risk of dementia.

VAT Score Improves Predictive Value of MMSE for Dementia

VAT Score Improves Predictive Value of MMSE for Dementia

Administering the Visual Association Test improves the predictive value of the Mini-Mental State Examination score for dementia.

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