Neurodegenerative Diseases

Atrial Fibrillation Tied to Higher Dementia Risk in Older Adults

Atrial Fibrillation Tied to Higher Dementia Risk in Older Adults

Atrial fibrillation is associated with a faster global cognitive decline and an increased risk for dementia in older people.

PET imaging of tau may help distinguish Alzheimer Disease from other neurodegenerative disorders

In this cross-sectional study, the tau marker [18F]flortaucipir accurately distinguished Alzheimer's Disease dementia from other non-AD neurodegenerative disorders about 90% of the time.

Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

Tau PET Is a Reliable Biomarker for Cognitive Decline in Older Adults

By

Investigators evaluated cognition with measures reflecting executive function, episodic memory, semantic fluency, and processing speed on an annual basis.

Positive Link Between Air Pollution, Diagnosis of Dementia

Positive Link Between Air Pollution, Diagnosis of Dementia

There is a positive association between residential levels of air pollution and being diagnosed with dementia.

Age, Sex, <i>APOE</i> Genotype Identify Alzheimer's, Dementia Risk

Age, Sex, APOE Genotype Identify Alzheimer's, Dementia Risk

Age, sex and apolipoprotein E genotype can identify groups at high 10-year risk for Alzheimer disease and all dementia.

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple Pathways Explain Age-Linked Increase in Dementia Risk

Multiple pathways account for the age-related increases in dementia risk.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

The burden of Alzheimer disease and related dementias is expected to increase to 3.3% in the United States by 2060.

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

By

Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.

Improved cardiovascular health associated with lower incidence of dementia in older adults

In this prospective cohort study, older patients with more optimal cardiovascular health metrics had a lower rate of developing dementia in a dose-dependent manner.

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal Abnormalities May Indicate Preclinical Alzheimer's

Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer disease.

Pseudobulbar Affect: Signs, Symptoms, and Treatment for Uncontrollable Laughing or Crying

Pseudobulbar Affect: Signs, Symptoms, and Treatment for Uncontrollable Laughing or Crying

By

Pseudobulbar affect is a significant national health issue in the United States, with approximately 2 million individuals affected.

Late-Life Blood Pressure Associated With Alzheimer Disease Brain Pathology

Late-Life Blood Pressure Associated With Alzheimer Disease Brain Pathology

By

Patients with a higher mean systolic blood pressure during follow-up had increased odds for brain infarcts compared with those with lower levels.

Low Fasting Insulin Associated With Long-Term Dementia Risk

Low Fasting Insulin Associated With Long-Term Dementia Risk

By

Having high insulin at baseline was associated with a greater risk for incident diabetes mellitus compared with low insulin values.

Cardiovascular Health Tied to Dementia Risk in Older Adults

Cardiovascular Health Tied to Dementia Risk in Older Adults

For older adults, increased numbers of optimal cardiovascular health metrics are associated with reduced risk of dementia.

VAT Score Improves Predictive Value of MMSE for Dementia

VAT Score Improves Predictive Value of MMSE for Dementia

Administering the Visual Association Test improves the predictive value of the Mini-Mental State Examination score for dementia.

Both Abstinence and High Alcohol Use Linked to Dementia

Both Abstinence and High Alcohol Use Linked to Dementia

Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.

Tau Associated With Loss of Anterior Temporal White Matter Integrity

Tau Associated With Loss of Anterior Temporal White Matter Integrity

By

Tau was found to be a significant predictor of mean diffusivity in the anterior temporal white matter.

Monoclonal Antibody Granted Orphan Drug Status for Frontotemporal Dementia

Monoclonal Antibody Granted Orphan Drug Status for Frontotemporal Dementia

By

There are currently no treatments available for frontotemporal dementia.

PET Imaging Can Measure Synaptic Loss From Alzheimer's

PET Imaging Can Measure Synaptic Loss From Alzheimer's

Positron emission tomographic imaging can directly measure synaptic loss with Alzheimer disease.

Confabulations Linked to Impaired Mental Time Travel in Alzheimer Disease

Confabulations Linked to Impaired Mental Time Travel in Alzheimer Disease

By

The findings suggest that confabulations by patients with AD are related to an impaired ability to mentally go back in time to retrieve the context in which the confabulated memories were encoded.

Link Between Lower Cognitive Ability in Young Adults and Risk for Dementia

Link Between Lower Cognitive Ability in Young Adults and Risk for Dementia

By

Lower cognitive ability total and verbal ability scores were predictive of greater risk for early-onset dementia.

Promising Improvements in Mild Cognitive Impairment With Investigational NA-831

Promising Improvements in Mild Cognitive Impairment With Investigational NA-831

By

Researchers from NeuroActiva, Inc. presented results of their randomized, double-blind, placebo-controlled phase 2A clinical trial of NA-831.

Twice-Daily Oxaloacetate Activates Brain Bioenergetic Metabolism in Alzheimer Disease

Twice-Daily Oxaloacetate Activates Brain Bioenergetic Metabolism in Alzheimer Disease

By

The study assessed the pharmacokinetics and pharmacodynamics of 2 doses of oxaloacetate in patients with Alzheimer disease.

New Monoclonal Antibody BAN2401 Reduces Amyloid Plaques, Improves Cognition in Alzheimer's

New Monoclonal Antibody BAN2401 Reduces Amyloid Plaques, Improves Cognition in Alzheimer's

By

Initial data from Study 201, as announced in December 2017, showed BAN2401 did not meet the primary endpoint.

Investigating the Effects of Z-Drugs in Dementia Patients With Sleep Disturbances

Investigating the Effects of Z-Drugs in Dementia Patients With Sleep Disturbances

By

Existing data from the the UK Clinical Practice Research Datalink (CPRD) and 3 clinical studies of PwD were used to evaluate the association between Z-drug administration and the incidence of adverse events.

Metformin Associated With Increased Dementia Risk in African Americans With Diabetes

Metformin Associated With Increased Dementia Risk in African Americans With Diabetes

By

Participants in this study were part of the Indianapolis-Ibadan Dementia Project that took place from 1992 to 2011 and were assessed for dementia every second or third year during follow-up.

Pimavanserin Confers Greater Improvements in Alzheimer Disease Psychosis vs Placebo

Pimavanserin Confers Greater Improvements in Alzheimer Disease Psychosis vs Placebo

By

Pimavanserin is currently approved in the United States for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis.

Transdermal Buprenorphine Not Well Tolerated in Dementia

Transdermal Buprenorphine Not Well Tolerated in Dementia

By

The researchers conducted a 13-week study that included 162 individuals with advanced dementia and considerable depression residing in nursing homes in Norway.

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

By

Although treatment with nabilone significantly improved agitation, cognition, and nutrition, the authors cautioned that sedation should be closely monitored.

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

By

Drinking sugary beverages has been previously linked to markers of preclinical Alzheimer disease, but the risk associated with consuming added sugars is not established.

Sign Up for Free e-newsletters



CME Focus