Neurodegenerative Diseases

Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

Trial of Verubecestat for Prodromal Alzheimer Disease Discontinued

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Merck announced the discontinuation of the Phase 3 APECS study for the treatment of AD.

Tamsulosin Associated With Dementia Risk in Older Patients With BPH

Tamsulosin Associated With Dementia Risk in Older Patients With BPH

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Because of the study's nonrandomized and observational design, the investigators were unable to determine any causal relationships between tamsulosin and dementia risk.

Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease

Plasma Neurofilament Light Indicative of Neuronal Damage in Huntington Disease

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In both the cortical and subcortical gray matter and white matter, higher baseline Nfl concentrations were associated with reduced brain volume.

Premature Dementia Risk Increased in Those With Heart Defects

Premature Dementia Risk Increased in Those With Heart Defects

An increased risk of dementia is assocaited with congenital heart disease.

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

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The 400 mg solanezumab dose used in this study may not have been sufficient enough to provide clinically meaningful effects in these patients.

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

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Investigators sought to examine factors that influence a cognitively normal individual's risk for developing symptoms of mild cognitive impairment due to Alzheimer disease.

Positive Opinions on Age May Help Ward Off Dementia

Positive Opinions on Age May Help Ward Off Dementia

Positive beliefs on age may protect against dementia.

Alzheimer Disease May Benefit From Deep Brain Stimulation

Alzheimer Disease May Benefit From Deep Brain Stimulation

The use of DBS in patients with Alzheimer disease is well tolerated and associated with less decline on the CDR-SB.

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

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A study was conducted to assess potential beneficial effects of a lifestyle intervention program on cognition in carriers of the APOE ε4 allele.

Dementia Less Likely in Vision-Tested Drivers Who Crash

Dementia Less Likely in Vision-Tested Drivers Who Crash

For older adults who are hospitalized after car crashes, vision testing and renewal requirements show to be related to reduced prevalence of dementia.

Solanezumab Has No Effect on Cognitive Decline in Alzheimer Disease

Solanezumab Has No Effect on Cognitive Decline in Alzheimer Disease

Solanezumab does not alter cognitive decline in patients with mild Alzheimer disease.

Lifestyle Intervention May Improve Cognition in APOEε4 Carriers

Lifestyle Intervention May Improve Cognition in APOEε4 Carriers

In older at-risk individuals, even APOE ε4 carriers, a multidomain lifestyle intervention seems to be beneficial.

Caffeinated, Sugary Soda Consumption Associated With Early Onset of Huntington Disease

Caffeinated, Sugary Soda Consumption Associated With Early Onset of Huntington Disease

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Sugar found in caffeinated soda is associated with increased systemic inflammatory processes that may in turn be associated with neurodegeneration.

Dementia With Lewy Bodies Benefits From Adjunctive Zonisamide

Dementia With Lewy Bodies Benefits From Adjunctive Zonisamide

Zonisamide as an adjunct to levodopa therapy improves parkinsonism in patients with dementia with Lewy bodies.

Alternative Genetic Risk Variant for Alzheimer Disease Identified

Alternative Genetic Risk Variant for Alzheimer Disease Identified

Brain amyloidosis is associated with certain Alzheimer disease risk variants.

Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

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Because of dementia's prolonged disease course, advance care decisions and planning are often overlooked until it is too late.

No Cognitive Improvement With Idalopirdine in Mild Alzheimer Disease

No Cognitive Improvement With Idalopirdine in Mild Alzheimer Disease

For patients with mild-to-moderate Alzheimer disease, the use of idalopirdine does not improve cognition.

Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive Impairment

Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive Impairment

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A lower education level was associated with higher MCI prevalence in 8 of the class I studies.

Risk for Cognitive Decline, Dementia Linked to Age-Related Hearing Loss

Risk for Cognitive Decline, Dementia Linked to Age-Related Hearing Loss

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Clinicians might benefit from standard guidelines on how to assess and refer patients with hearing loss.

Increased Dementia Risk Seen in Rheumatic Diseases

Increased Dementia Risk Seen in Rheumatic Diseases

There is an increased risk of dementia for patients with rheumatic diseases.

Increased Midlife Triglyceride Levels Predictive of Alzheimer Disease Pathology

Increased Midlife Triglyceride Levels Predictive of Alzheimer Disease Pathology

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If confirmed in future studies, high triglycerides may present a modifiable risk factor for Alzheimer disease.

Limited Evidence Supports Physical Interventions for Dementia Prevention

Limited Evidence Supports Physical Interventions for Dementia Prevention

A hanful of studies reviewed the different types of interventions to prevent late-life dementia.

No Benefit for Transcranial Direct Current Stimulation on Short-Term Memory

No Benefit for Transcranial Direct Current Stimulation on Short-Term Memory

Anodal tDCS might not enhance short-term memory in healthy individuals when applied to the left DLPFC.

Sleep Disruptions Associated With Increased Amyloid Production

Sleep Disruptions Associated With Increased Amyloid Production

Increased amyloid-β production in adults can lead to disrupted sleep.

Exercise, Physical Therapy May Provide Long-Term Functional Improvement in Huntington Disease

Exercise, Physical Therapy May Provide Long-Term Functional Improvement in Huntington Disease

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Interventions aimed at motor and cognitive impairments in Huntington disease may result in long-term functional improvement.

Dementia Associated With Serum Magnesium Levels

Dementia Associated With Serum Magnesium Levels

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An increased risk for all-cause dementia is associated with low and high serum magnesium levels.

Proton Pump Inhibitor Use Not Associated With Increased Dementia Risk

Proton Pump Inhibitor Use Not Associated With Increased Dementia Risk

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A population-based cohort study evaluated whether proton pump inhibitor use was associated with an increased risk for dementia.

Obesity and Alzheimer Disease: Exploring Risk Modification

Obesity and Alzheimer Disease: Exploring Risk Modification

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Throughout the life course, higher body mass index and obesity are linked to cognitive decline, brain atrophy, reduced white matter and integrity of the blood-brain barrier, and elevated risk for late-onset Alzheimer disease.

Number of Americans With Alzheimer Disease Expected to More Than Double by 2060

Number of Americans With Alzheimer Disease Expected to More Than Double by 2060

It is predicted that by 2060, a total of 15 million American's will have clinical Alzheimer disease or mild cognitive impairment.

Amyloid-Beta Deposition, Decreased Hippocampal Volume Associated with Functional Decline in Elderly

Amyloid-Beta Deposition, Decreased Hippocampal Volume Associated with Functional Decline in Elderly

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This analysis was comprised of well-educated and mostly white patients, so these findings may be difficult to generalize to all populations.

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