Neuromuscular Disorders

MS Relapse Drops During Pregnancy but Rises After

MS Relapse Drops During Pregnancy but Rises After

Rates of multiple sclerosis relapse decrease during pregnancy but increase postpartum.

Many Patients Do Not Engage Health Care Provider During MS Relapse

Many Patients Do Not Engage Health Care Provider During MS Relapse

The rate and frequency of relapse vary for patients with multiple sclerosis, and many report not visiting a health care provider during relapse.

FDA: Risk of Severe Increase in Disability Following MS Treatment Discontinuation

FDA: Risk of Severe Increase in Disability Following MS Treatment Discontinuation

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From September 2010 to February 2018, the FDA has identified 35 cases of severe increased disability accompanied by the presence of new lesions on MRI that occurred 2 to 24 weeks after stopping treatment with fingolimod.

Ocrevus Labeling Updated With New Info on Timing of Vaccine Administration

Ocrevus Labeling Updated With New Info on Timing of Vaccine Administration

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According to a Phase 3b open-label study, Ocrevus may interfere with the effectiveness of non-live vaccines.

Approaches for Better Diagnosis of Pediatric Multiple Sclerosis

Approaches for Better Diagnosis of Pediatric Multiple Sclerosis

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Pediatric MS is predominantly inflammatory in nature, with a presentation that is similar to a number of other conditions.

Incidence of Guillain-Barré Syndrome Linked With Recent Bone, Digestive Organ Surgery

Incidence of Guillain-Barré Syndrome Linked With Recent Bone, Digestive Organ Surgery

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A nationwide epidemiologic study in France examined a correlation between Guillain-Barré syndrome and recent bone or digestive organ surgery.

Nusinersen May Be Effective for Short-Term Motor Function Improvements in Spinal Muscular Atrophy

Nusinersen May Be Effective for Short-Term Motor Function Improvements in Spinal Muscular Atrophy

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Nusinersen, an antisense oligonucleotide that increases functional SMN protein production from SMN2, was clinically effective for improving motor function.

Comorbidities in Multiple Sclerosis: Effects on DMTs, the Treatment Team, and More

Comorbidities in Multiple Sclerosis: Effects on DMTs, the Treatment Team, and More

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Having a higher burden of comorbidities is associated with greater disability progression and lower QoL, as well as increased healthcare utilization and mortality.

Rates of Multiple Sclerosis Relapses Vary Before, During, and After Pregnancy

Rates of Multiple Sclerosis Relapses Vary Before, During, and After Pregnancy

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Investigators sought to determine relapse rates of multiple sclerosis decrease prior to pregnancy, during pregnancy, and postpartum.

Tiglutik Now Available for the Treatment of Amyotrophic Lateral Sclerosis

Tiglutik Now Available for the Treatment of Amyotrophic Lateral Sclerosis

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Tiglutik is supplied as a thickened riluzole liquid that is intended to ease administration for patients with dysphagia.

Cannabinoids Mildly Effective for Treating MS Symptoms in Adults

Cannabinoids Mildly Effective for Treating MS Symptoms in Adults

Cannabinoids may be mildly effective at treating spasticity, pain, and bladder dysfunction in adults with multiple sclerosis.

Fingolimod shows superior efficacy to interferon beta-1a in pediatric multiple sclerosis: the PARADIGMS trial

Among pediatric patients with relapsing multiple sclerosis, fingolimod was associated with a lower annualized rate of relapse and lower incidence of new lesions identified on T2-weighted magnetic resonance imaging (MRI) compared to interferon beta-1a.

DMTs Do Not Moderate Disability in Patients With MS and Diabetes, Other Comorbidities

DMTs Do Not Moderate Disability in Patients With MS and Diabetes, Other Comorbidities

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All participants were smokers or had either diabetes, cancer, depression, cardiovascular, respiratory, thyroid, or gastrointestinal disease and were receiving a DMT.

Glatiramer Acetate Associated With Long-Term Disability Improvements in MS

Glatiramer Acetate Associated With Long-Term Disability Improvements in MS

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Natural history data from a subset of patients from the British Columbia MS database between 1980 to 1996 were used to create a continuous Markov model to model the projected course of disease in untreated people with RMS.

Fingolimod Compared With Glatiramer Acetate in Head-to-Head MS Study

Fingolimod Compared With Glatiramer Acetate in Head-to-Head MS Study

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Compared with Copaxone injection, treatment with oral Gilenya significantly reduced the annualized relapse rate in patients with relapsing remitting multiple sclerosis.

Biobank Data Suggest Vitamin D Reduces Risk for Multiple Sclerosis

Biobank Data Suggest Vitamin D Reduces Risk for Multiple Sclerosis

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Researchers categorized samples into quintiles based on 25(OH)D3 concentrations in healthy controls.

High-Dose Biotin May Be an Effective Treatment for Progressive MS

High-Dose Biotin May Be an Effective Treatment for Progressive MS

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Patients with progressive MS or secondary progressive MS who were receiving care at a single institution in France were prescribed 300 mg/day MD1003.

MS Relapse Rates After DMT Initiation Similar Between Pediatric-, Adult-Onset MS

MS Relapse Rates After DMT Initiation Similar Between Pediatric-, Adult-Onset MS

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Disability progression is slower among patients with pediatric-onset multiple sclerosis.

Lower Relapse Risk and Disability Progression With Oral DMT in Treatment-Naive RRMS

Lower Relapse Risk and Disability Progression With Oral DMT in Treatment-Naive RRMS

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In patients with relapse-remitting multiple sclerosis, the initiation of oral disease-modifying therapies is associated with a lower relapse risk as well as a lower risk for disability progression.

Disease Modifying Therapy Associated With Persistent Brain Atrophy Slowing in MS

Disease Modifying Therapy Associated With Persistent Brain Atrophy Slowing in MS

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Investigators examine the effect of disease-modifying therapy on the rate of brain atrophy in patients with multiple sclerosis.

Patients With Multiple Sclerosis Face Greater Infection Risk

Patients With Multiple Sclerosis Face Greater Infection Risk

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Patients with MS also have a higher risk for serious hospitalized-related infections compared with hospitalized patients without MS.

Alemtuzumab Improves Disability, Prognosis in Treatment-Refractory MS

Alemtuzumab Improves Disability, Prognosis in Treatment-Refractory MS

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Study investigators assessed the changes in the Expanded Disability Status Scale and MS Severity Score after up to 7 courses of alemtuzumab.

Fingolimod Significantly Improves Quality of Life in Pediatric MS

Fingolimod Significantly Improves Quality of Life in Pediatric MS

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The phase 3 PARADIGMS trial involving 215 pediatric patients demonstrated superior efficacy for fingolimod over interferon beta-1a.

Use of Disease Modifying Therapies for Multiple Sclerosis Has No Ill Effect on Pregnancy Outcomes

Use of Disease Modifying Therapies for Multiple Sclerosis Has No Ill Effect on Pregnancy Outcomes

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Patients were divided into 3 groups: patients not treated in the 3 months before pregnancy, patients treated in the 3 months before pregnancy, and patients treated during pregnancy.

Ozanimod Reduces Severe Relapses in Multiple Sclerosis More Than Interferon Beta-1a

Ozanimod Reduces Severe Relapses in Multiple Sclerosis More Than Interferon Beta-1a

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Treatments were evaluated for either 1 year (SUNBEAM) or 2 years (RADIANCE).

Copaxone 3 Times Weekly Safe, Effective for Ambulatory Patients With Relapsing MS

Copaxone 3 Times Weekly Safe, Effective for Ambulatory Patients With Relapsing MS

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Participants showed a significant decrease in annual relapse rate and a significant improvement in both patient-reported disability scores and information processing scores.

Serious Adverse Events Profile for Cladribine Confirmed With Extended Data

Serious Adverse Events Profile for Cladribine Confirmed With Extended Data

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Researchers pooled long-term data on the safety of cladribine tablets monotherapy that extended 3 or more years beyond the data included in the last clinical study.

Multiple Sclerosis Comorbidities Affect Work Participation, Daily Function

Multiple Sclerosis Comorbidities Affect Work Participation, Daily Function

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Surveys were given out to individuals in the Australian Multiple Sclerosis Longitudinal Study between August and December 2016.

Change in Dietary Patterns Over 5 Years in Early Multiple Sclerosis

Change in Dietary Patterns Over 5 Years in Early Multiple Sclerosis

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Researchers analyze the dietary habits of 260 patients in the early stages of multiple sclerosis from baseline to 5 years after initial onset of symptoms.

Cladribine Tablets Reduce Relapses in Relapsing-Remitting Multiple Sclerosis

Cladribine Tablets Reduce Relapses in Relapsing-Remitting Multiple Sclerosis

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Reserachers evaluated data from the CLARITY study to test the efficacy of cladribine tablets on frequency and severity of relapses for patients with multiple sclerosis.

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