Neuromuscular Disorders

AAN: Occupational Exposure to Diesel Exhaust Tied to ALS Risk

AAN: Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Researchers found that for men with any occupational exposure to diesel exhaust, the odds ratio for amyotrophic lateral sclerosis increased with increasing lag periods.

AAN: High Fish Intake Linked to Reduced Risk of Multiple Sclerosis

AAN: High Fish Intake Linked to Reduced Risk of Multiple Sclerosis

Compared with consuming fish less than once per month and no supplements, high fish intake was correlated with a significantly reduced risk of multiple sclerosis.

Scoliosis Surgery Found Beneficial for Cerebral Palsy Patients

Scoliosis Surgery Found Beneficial for Cerebral Palsy Patients

Scoliosis surgery in patients with cerebral palsy leads to a significant improvement in health-related quality of life.

Pinpointing Clinically Meaningful Change in Cervical Dystonia Treated With Botulinum Toxin

Pinpointing Clinically Meaningful Change in Cervical Dystonia Treated With Botulinum Toxin

By

The administration of treatment was performed over 5 treatment cycles, and the investigators assessed TWSTRS changes at baseline and 4 weeks following injection.

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

By

Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

By

Patients who received 100 mg/day riluzole spent significantly more time in stage 4 than patients who were randomly assigned to placebo.

Firdapse NDA Submitted for Lambert-Eaton Myasthenic Syndrome

Firdapse NDA Submitted for Lambert-Eaton Myasthenic Syndrome

By

Results from the Phase 3 trial showed that the Quantitative Myasthenia Gravis (QMG) score at baseline to day 14 changed from 6.4 to 6.7 in the amifampridine group vs. 5.6 to 7.9 for the placebo group.

Primary Periodic Paralysis: A Physician's Personal Experience as a Patient

Primary Periodic Paralysis: A Physician's Personal Experience as a Patient

By

Neurology Advisor spoke with Annabelle Baughan, a retired hematologist-oncologist, who shared her personal experience with Andersen-Tawil syndrome.

First-in-Class Inhibitor Designated Orphan Drug for Spinal Muscular Atrophy

First-in-Class Inhibitor Designated Orphan Drug for Spinal Muscular Atrophy

By

By inhibiting the activation of myostatin, SRK-015 may promote a clinically meaningful increase in muscle mass and strength.

Improvement in Acute Optic Neuritis Similar With IV, Oral Corticosteroids

Improvement in Acute Optic Neuritis Similar With IV, Oral Corticosteroids

By

The advantages of oral prednisone include "being less expensive and more convenient to access and administer and [being] preferred by patients to [intravenous] methylprednisolone."

DMT Discontinuation in Older MS Patients: Clinical Outcomes Examined

DMT Discontinuation in Older MS Patients: Clinical Outcomes Examined

By

Of the total patients, 178 (29.7%) discontinued DMT during the study period with only 1 documented relapse occurring in the discontinuers.

Siponimod Reduces Disability Progression in Secondary Progressive Multiple Sclerosis

Siponimod Reduces Disability Progression in Secondary Progressive Multiple Sclerosis

By

Further research should focus on establishing whether siponimod exerts its effect on the pathogenic processes associated with disease progression or activity, or both.

Apheresis Associated With Clinical Improvement in Early Active Multiple Sclerosis

Apheresis Associated With Clinical Improvement in Early Active Multiple Sclerosis

By

The study was unable to verify whether the findings may be applicable for lesion locations other than those found with brain biopsies.

Evidence of Impaired Glucose Signaling in Amyotrophic Lateral Sclerosis

Evidence of Impaired Glucose Signaling in Amyotrophic Lateral Sclerosis

By

Further research is warranted to clarify the role played by insulin resistance in the pathogenesis of amyotrophic lateral sclerosis.

Combined Exercise Training Increases BDNF in Relapsing-Remitting MS

Combined Exercise Training Increases BDNF in Relapsing-Remitting MS

By

The effect of 8 weeks of combined exercise training on serum BDNF concentration was examined in patients with relapsing-remitting multiple sclerosis.

Smoking Associated With Increased Relapse Rate in Interferon Beta-Treated Relapsing-Remitting MS

Smoking Associated With Increased Relapse Rate in Interferon Beta-Treated Relapsing-Remitting MS

By

A cohort study evaluated the effects of smoking on disease activity in interferon beta-treated relapsing-remitting multiple sclerosis.

Female Gender, Natalizumab Exposure Associated With Increased Lymphopenia Risk in FNG-Treated MS

Female Gender, Natalizumab Exposure Associated With Increased Lymphopenia Risk in FNG-Treated MS

By

The impact of treatment with dimethyl fumarate and fingolimod on lymphocyte and leukocyte count was evaluated in patients with multiple sclerosis.

Prevalence of ALS Remains Steady in US

Prevalence of ALS Remains Steady in US

The prevalence of ALS in the United States has been steady.

Later-Onset Spinal Muscular Atrophy Benefits From Nusinersen

Later-Onset Spinal Muscular Atrophy Benefits From Nusinersen

By

Improved motor function was observed among more participants in the nusinersen group compared with those in the control group.

Reduced Risk for Multiple Sclerosis Linked to Greater Sun Exposure

Reduced Risk for Multiple Sclerosis Linked to Greater Sun Exposure

Risk of multiple sclerosis may be reduced with high sun exposure.

Genetics May Hold the Key to Decoding Periodic Paralysis

Genetics May Hold the Key to Decoding Periodic Paralysis

By

The cluster of diagnoses known as periodic paralyses — including hypokalemic periodic paralysis, hyperkalemic periodic paralysis, and Anderson-Tawil syndrome — are rare genetic disorders of spontaneous muscle weakness or paralysis that can last from minutes to days.

Multiple Sclerosis Drug Zinbryta Withdrawn From the Market

Multiple Sclerosis Drug Zinbryta Withdrawn From the Market

By

Daclizumab, an interleukin-2 (IL-2) receptor blocking antibody, was approved in May 2016 to treat adults with relapsing forms of MS.

New Scoring System for Predicting Survival in Myotonic Dystrophy Type 1

New Scoring System for Predicting Survival in Myotonic Dystrophy Type 1

By

Age, diabetes, need for support when walking, heart rate, systolic blood pressure, first-degree atrioventricular block, bundle-branch block, and vital lung capacity were all linked to death.

Arimoclomol Shows Promise for Treating Rapidly Progressive <i>SOD1</i> ALS

Arimoclomol Shows Promise for Treating Rapidly Progressive SOD1 ALS

By

Due to the rarity of rapidly progressive SOD1 ALS, this study had a small sample size and may be limited in power.

New Glatiramer Acetate Dose Available for Relapsing Multiple Sclerosis

New Glatiramer Acetate Dose Available for Relapsing Multiple Sclerosis

By

Glatopa 40 mg has been launched for the treatment of relapsing multiple sclerosis.

Shortcomings in ALS Research: Strategies for Improvement

Shortcomings in ALS Research: Strategies for Improvement

By

Researchers recently identified 5 key challenges that collectively hinder the design of amyotrophic lateral sclerosis clinical trials and the development of new treatments.

Prenatal Exposure to Natalizumab in MS Linked to Miscarriage Risk

Prenatal Exposure to Natalizumab in MS Linked to Miscarriage Risk

Natalizumab exposure is associated with an increased risk of spontaneous abortion for pregnant women with multiple sclerosis.

Nusinersen improves motor function in children with later-onset spinal muscular atrophy: The CHERISH trial

Intrathecal injections of nusinersen in pediatric later-onset spinal muscular atrophy (SMA) patients were associated with increased clinical motor function scores compared to sham treated patients.

Improved Balance in MS With Vestibular-Focused Rehab

Improved Balance in MS With Vestibular-Focused Rehab

A vestibular-related rehabilitation program is associated with imrpoved outcomes for patients with multiple sclerosis.

Quality of Life in Relapsing vs Progressive Multiple Sclerosis

Quality of Life in Relapsing vs Progressive Multiple Sclerosis

By

Data obtained from the iConquerMS network highlight areas of quality of life that affect people with relapsing and progressive forms of MS and provide substantial basis for future research.

Sign Up for Free e-newsletters

CME Focus