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The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

Geoffrey Littlejohn, MD, provides a clinical perspective on the pathophysiology of fibromyalgia and the role of neurogenic inflammation in the disease process.

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FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

The treatment is currently being evaluated in a Phase 2 study (ELEVATE) in patients with major depressive disorder who have had an inadequate response to standard antidepressant therapy.

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

Pregabalin does not appear to be effective for controlling pain in patients with chronic post-traumatic peripheral neuropathic pain.

ZTlido Patch for Post-Shingles Pain Launching Soon

ZTlido Patch for Post-Shingles Pain Launching Soon

The non-aqueous adhesive patch requires 36mg per topical system to achieve the same therapeutic dose as Lidoderm (lidocaine 5%) which contains 700mg per patch.

Increased Corticomotor Excitability ID'd in Restless Legs

Increased Corticomotor Excitability ID'd in Restless Legs

For patients with restless leg syndrome, the primary motor cortex (M1) exhibits hyperexcitability, which is associated with disease severity.

Trial Evaluating BCG Vaccine for Fibromyalgia Given Green Light by FDA

Trial Evaluating BCG Vaccine for Fibromyalgia Given Green Light by FDA

The investigators hope that the BCG vaccine can increase anti-inflammatory cytokines, which are deficient in patients with fibromyalgia.

Fingolimod Does Not Slow Worsening of Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Fingolimod Does Not Slow Worsening of Chronic Inflammatory Demyelinating Polyradiculoneuropathy

The trial was ended for futility when a total of 44 worsening events had occurred in the cohort.

Electrophysiologic Features Specific to Transthyretin Familial Amyloid Polyneuropathies

Electrophysiologic Features Specific to Transthyretin Familial Amyloid Polyneuropathies

Reduced amplitude of the ulnar motor nerve and the sural nerve action potentials may be specific to transthyretin familial amyloid polyneuropathies, allowing us to distinguish this disorder from other demyelinating polyneuropathies.

Various Factors Affect Progress in Back-Related Leg Pain, Sciatica

Various Factors Affect Progress in Back-Related Leg Pain, Sciatica

In back-related leg pain and sciatica patients, belief in a long recovery and the number of other symptoms attributed to the pain are independently negatively associated with improvement.

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

Investigators evaluated the performance of the CAPPRI in assessing health-related quality-of-life outcomes in patients with diabetic distal sensorimotor polyneuropathy.

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

Mirtazapine is a central alpha-2 antagonist currently FDA-approved for the treatment of major depressive disorder.

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