Neuropathic Pain

Increased Corticomotor Excitability ID'd in Restless Legs

Increased Corticomotor Excitability ID'd in Restless Legs

For patients with restless leg syndrome, the primary motor cortex (M1) exhibits hyperexcitability, which is associated with disease severity.

Trial Evaluating BCG Vaccine for Fibromyalgia Given Green Light by FDA

Trial Evaluating BCG Vaccine for Fibromyalgia Given Green Light by FDA

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The investigators hope that the BCG vaccine can increase anti-inflammatory cytokines, which are deficient in patients with fibromyalgia.

Pregabalin may increase the risk of death when coprescribed with opioids

Patients coprescribed opioids and pregabalin had significantly increased odds of opioid-related death compared to opioid prescription alone.

Fingolimod Does Not Slow Worsening of Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Fingolimod Does Not Slow Worsening of Chronic Inflammatory Demyelinating Polyradiculoneuropathy

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The trial was ended for futility when a total of 44 worsening events had occurred in the cohort.

First-in-Class Therapy Approved for Polyneuropathy Caused by hATTR

First-in-Class Therapy Approved for Polyneuropathy Caused by hATTR

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The mechanism of siRNAs consists of silencing a portion of RNA involved in causing the disease.

Patisiran is effective in treatment of hereditary transthyretin amyloidosis.

Patisiran, an RNA interference agent, improved neuropathy symptoms and motor function in patients with hereditary transthyretin amyloidosis after 18 months of use.

Electrophysiologic Features Specific to Transthyretin Familial Amyloid Polyneuropathies

Electrophysiologic Features Specific to Transthyretin Familial Amyloid Polyneuropathies

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Reduced amplitude of the ulnar motor nerve and the sural nerve action potentials may be specific to transthyretin familial amyloid polyneuropathies, allowing us to distinguish this disorder from other demyelinating polyneuropathies.

The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

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Geoffrey Littlejohn, MD, provides a clinical perspective on the pathophysiology of fibromyalgia and the role of neurogenic inflammation in the disease process.

Various Factors Affect Progress in Back-Related Leg Pain, Sciatica

Various Factors Affect Progress in Back-Related Leg Pain, Sciatica

In back-related leg pain and sciatica patients, belief in a long recovery and the number of other symptoms attributed to the pain are independently negatively associated with improvement.

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

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Investigators evaluated the performance of the CAPPRI in assessing health-related quality-of-life outcomes in patients with diabetic distal sensorimotor polyneuropathy.

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

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Mirtazapine is a central alpha-2 antagonist currently FDA-approved for the treatment of major depressive disorder.

Examining the Therapeutic Possibilities of Nutrition in Fibromyalgia

Examining the Therapeutic Possibilities of Nutrition in Fibromyalgia

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Providing guidance to improve dietary behavior, which may include supplementation to achieve an optimal nutritional status, can contribute to improved control of fibromyalgia symptoms.

Morphologic Changes in Primary Somatosensory System May Fuel Restless Leg Symptoms

Morphologic Changes in Primary Somatosensory System May Fuel Restless Leg Symptoms

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Compared with control patients, patients with restless leg syndrome symptoms experienced a morphologic change in the brain somatosensory system.

Peripheral Neuropathy Common in Childhood Cancer Survivors

Peripheral Neuropathy Common in Childhood Cancer Survivors

Childhood cancer survivors frequently have clinical abnormalities attributable to peripheral neuropathy.

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

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The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

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Specific countries officially recommend some screening questionnaires for the early assessment of neuropathic pain, with France recommending the DN4 and Germany recommending PainDETECT.

Expert Insight: A Closer Look at Neurological Manifestations of Sjogren Syndrome

Expert Insight: A Closer Look at Neurological Manifestations of Sjogren Syndrome

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Experts discuss the symptoms and prevalence of neurological manifestations in Sjogren syndrome.

AAN: Gluten-Free Diet May Help Cut Pain in Gluten Neuropathy

AAN: Gluten-Free Diet May Help Cut Pain in Gluten Neuropathy

For patients with gluten neuropathy, following a strict gluten-free diet is associated with significantly reduced odds of peripheral neuropathic pain.

Tai Chi Beats Aerobic Exercise in Fibromyalgia

Tai Chi Beats Aerobic Exercise in Fibromyalgia

Improvement in fibromyalgia impact questionnaire scores was greater for combined tai chi groups.

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

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The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Hizentra Approved for Chronic Inflammatory Demyelinating Polyneuropathy

Hizentra Approved for Chronic Inflammatory Demyelinating Polyneuropathy

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The PATH study demonstrated that the percentage of patients experiencing CIDP relapse or withdrawal for any other reason during SCIg treatment was significantly lower with Hizentra.

Blood Test to Detect Fibromyalgia Now Available

Blood Test to Detect Fibromyalgia Now Available

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A new blood test that uses RNA data to identify fibromyalgia has been released by IQuity.

Factors Associated With Gabapentin Overuse

Factors Associated With Gabapentin Overuse

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The odds of gabapentin overuse are significantly higher in patients who were co-prescribed opioids.

Topical Lidocaine Approved for Postherpetic Neuralgia Pain

Topical Lidocaine Approved for Postherpetic Neuralgia Pain

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The FDA has approved ZTlido to relieve pain associated with postherpetic neuralgia.

Treatments Vary in Trigeminal Neuralgia

Treatments Vary in Trigeminal Neuralgia

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Treatment patterns amont patients with trigeminal neuralgia suggest that this disorder carries a significant burden.

Restless Legs Syndrome Associated With Increased Cardiovascular Mortality

Restless Legs Syndrome Associated With Increased Cardiovascular Mortality

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Women with RLS are more likely to have cardiovascular-related comorbidities than those without RLS.

FDA Reviewing NDA for Hereditary aTTR Amyloidosis Gene-Silencing Therapy

FDA Reviewing NDA for Hereditary aTTR Amyloidosis Gene-Silencing Therapy

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The FDA has accepted Alnylam's New Drug Application for patisiran, and investigational drug for treating hereditary aTTR amyloidosis, for priority review.

Charcot-Marie-Tooth Disease Severity Indicated by Plasma Neurofilament Concentration

Charcot-Marie-Tooth Disease Severity Indicated by Plasma Neurofilament Concentration

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The measurement may provide a dynamic measure of axonal damage in a disease in which neuropathy is the only neurologic manifestation.

Guidelines: Opioids for the Treatment of Refractory Restless Legs Syndrome

Guidelines: Opioids for the Treatment of Refractory Restless Legs Syndrome

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For patients with restless leg syndrome, opioids may be very beneficial if taken in low daily doses.

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

Chronic pain symptoms in patients with PDPN are effectively reduced with spinal cord stimulation.

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