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Alzheimer's Disease and Dementia

“Morning People” at Higher Risk of Alzheimer Disease

The comorbidity of depressive disorders and late-life neurodegenerative diseases including Alzheimer disease has been widely reported. This study looks into whether there is a causal relationship existing between both or, if their co-occurrence is due to confounding or common risk factors, such as aging.
Neurobehavioral Disorders

Spravato Approved for MDD With Acute Suicidal Ideation or Behavior

The approval was based on the ASPIRE I and II trials that compared the efficacy and safety of esketamine, an N-methyl-D-aspartate receptor antagonist, to placebo in 449 adults with moderate to severe MDD who had active suicidal ideation and intent.
Neurobehavioral Disorders

Antipsychotics Linked to Adverse Changes in Brain Structure

Patients with psychotic depression who experienced an illness relapse while receiving placebo also had a decline in cortical thickness, emphasizing the essential role antipsychotics play in treating disorders where psychosis is present.
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