Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.
Investigators sought to determine whether brain pattern metabolic alterations in PD and FDG-PET SPM could predict dementia risk.
The use of subthalamic stimulation may be beneficial in managing psychobehavioral manifestations of Parkinson disease.
It may be best to deal with the PD subtype characterized by gait difficulty differently from the akinetic-rigid subtype.
The FDA has approved Osmolex ER for the treatment of Parkinson disease.
A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.
By 10 weeks, participants in the treatment group reported significant improvements in quality of life.
Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.
In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.
Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.
In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.
Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.
Several studies have uncovered sex-dependent variations in the symptomatic manifestations of Parkinson disease, as well as in the response to dopamine therapies.
The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.
Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.
Patient's with depression that have Parkinson's disease have impaired white matter integrity.
More men with Parkinson's disease have caregivers than women.
Numerous factors are likely contribute to the rate of progression, with different combinations of factors showing relevance for individual patients.
Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.
Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.
There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.
Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.
Sodium oxybate seems to be effective for patients with Parkinson disease and excessive daytime sleepiness.
Deep brain stimulation is traditionally conducted with the patient awake in order to help the ideal target for electrode placement.
Smoking may modify a genetic link with Parkinson disease.
While parkinsonian disorders share a common mechanism of protein aggregation, manifestations are quite varied.
The investigators suggested that the models should be recalibrated based on geographic location for more individualized predictions.
Cognitive dysfunction may be a sign of prodromal Parkinson disease.
Abnormal beta synchrony in the Parkinsonian basal ganglia is suppressed by bicycling.
The highest incidence rates of adverse effects in PD were linked with ropinirole, bromocriptine, and piribedil.
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