Parkinson's Disease

Reduced Survival for Patients With Idiopathic Parkinsonism

Reduced Survival for Patients With Idiopathic Parkinsonism

Patients with idiopathic parkinsonism have reduced survival, although survival is dependent on the type and characteristics of the parkinsonian disorder.

Removing Appendix May Lower Risk for Parkinson Disease

Removing Appendix May Lower Risk for Parkinson Disease

The normal human appendix seems to contain pathogenic forms of α-synuclein, which may impact the risk for developing Parkinson disease.

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

By

Gout may be associated with a higher risk for incident PD in older adults.

Half of Women to Develop Stroke, Dementia, or Parkinsonism

Half of Women to Develop Stroke, Dementia, or Parkinsonism

One in two women and one in three men will develop dementia, stroke, or parkinsonism during their lifetime.

Do β2‐Adrenoreceptor Medications Affect Parkinson Disease Risk?

Do β2‐Adrenoreceptor Medications Affect Parkinson Disease Risk?

By

In order to determine the risk of PD associated with various β2‐adrenoreceptor drugs, the study authors assessed United States Medicare beneficiary data from 2009.

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

Reverse Nocturnal BP Dipping Identifies Cardiovascular Dysautonomia in Parkinson Disease

By

A greater proportion of patients with dysautonomia had supine hypertension compared with patients without dysautonomia.

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

By

Investigators sought to determine if the ECAS diagnostic screening tool is sufficiently sensitive to distinguish between progressive supranuclear palsy and Parkinson disease.

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

By

A total of 42 consecutive patients with PD who underwent STN-DBS were enrolled in this study.

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

By

Sunovion announced that the FDA has accepted the NDA for apomorphine sublingual film to treat motor fluctuations seen in patients with Parkinson's.

The Future of Freezing of Gait in Parkinson's: Exploring Potential Treatments and Preventive Strategies

The Future of Freezing of Gait in Parkinson's: Exploring Potential Treatments and Preventive Strategies

By

More than half of patients diagnosed with Parkinson disease experience freezing of gait.

Emerging Innovations in Parkinson Disease Treatment: Q&A With Dr Matthew Brodsky

Emerging Innovations in Parkinson Disease Treatment: Q&A With Dr Matthew Brodsky

By

Surgical interventions for Parkinson disease are experiencing a swell in innovation, thanks in part to the entry of two additional medical device companies into a field previously dominated by one company.

IBD Associated With Increased Risk of Parkinson Disease

IBD Associated With Increased Risk of Parkinson Disease

There is a significantly increased risk of Parkinson disease in patients with inflammatory bowel disease.

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

By

Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.

IBD Associated With Increased Incidence of Parkinson Disease

IBD Associated With Increased Incidence of Parkinson Disease

Patients with IBD who were exposed to anti-TNF therapy had a significant decrease in incidence of PD.

Neuromodulation Therapy Gives Relief From Hand Tremor

Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

By

Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

By

Previous research has suggested a genetic and functional link between IBD and PD, however evidence regarding this association has been limited.

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

By

Researchers sought to assess outcomes in hospitalized patients with comorbid Parkinson disease and major depressive disorder following administration of deep brain stimulation.

Understanding Impulse Control Disorders in Parkinson Disease: Developments and Treatments

Understanding Impulse Control Disorders in Parkinson Disease: Developments and Treatments

By

In this article, we explore research findings to provide a deeper understanding of the factors associated with increased risk for impulse control disorders in Parkinson disease. Deputy Director of the Parkinson's UK charity, Professor David Dexter, also provides insights on the mechanisms of impulse control disorders and the implications of new findings on the management of Parkinson disease.

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Researchers say that tears may be an inexpensive, reliable, and noninvasive biological marker of Parkinson's disease.

Demoralization Common in Patients With Parkinson Disease

Demoralization Common in Patients With Parkinson Disease

Demoralization is common in patients with Parkinson disease and is associated with motor dysfunction.

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

By

Although deep brain stimulation, similar to all Parkinson disease therapies, cannot cure, modify, or slow progression of the disease, some recent research suggests that the symptom alleviation and quality-of-life improvement it provides might lead to mild improvements in longevity.

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia.

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

By

Sunovion announced the submission of its New Drug Application for apomorphine sublingual film for OFF episodes linked with PD.

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

By

Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

By

Investigators sought to determine whether brain pattern metabolic alterations in PD and FDG-PET SPM could predict dementia risk.

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

By

The use of subthalamic stimulation may be beneficial in managing psychobehavioral manifestations of Parkinson disease.

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

By

It may be best to deal with the PD subtype characterized by gait difficulty differently from the akinetic-rigid subtype.

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

By

The FDA has approved Osmolex ER for the treatment of Parkinson disease.

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

By

A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.

Sign Up for Free e-newsletters



CME Focus