Parkinson’s Disease

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

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Study investigators enrolled a total of 37 patients with PD who had participated in a larger prospective, controlled exercise study.

Strong Link Identified Between T2DM and Parkinson Disease

Strong Link Identified Between T2DM and Parkinson Disease

There is an increased rate of subsequent Parkinson disease among individuals diagnosed with type 2 diabetes mellitus.

Parkinson's Medications Tied to Impulse Control Disorders

Parkinson's Medications Tied to Impulse Control Disorders

For patients with Parkinson disease, dopamine agonist use is associated with incidence of impulse control disorders in a dose-effect relationship.

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

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Investigators tested functional connectivity between the right and left hypothalamus as well as the other brain regions by using the seed-to-voxel strategy.

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

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Despite evidence suggesting there is an impact of physical activity and body mass index on the risk for Parkinson disease, a large prospective study published in Neurology shows that there is no significant association between prolonged sitting/inactivity or obesity with PD risk.

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

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Patients with TBI had a higher incidence of PD compared with patients without TBI.

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

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The assessment of psychiatric symptoms relied on only one question in the MDS-UPDRS, potentially leading to underestimation of these symptoms in this cohort.

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

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Several prodromal symptoms in REM sleep behavior disorder are highly associated with conversion to neurodegenerative diseases.

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

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Wearable technology may help monitor on/off states in patients with Parkinson disease in an outpatient setting.

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

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ADS-5102 is a promising treatment option: if taken once daily at night, it achieves highest plasma drug concentrations throughout the day when symptoms are most bothersome.

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

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Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.

Palliative Care in Movement Disorders: Recommendations for Improvement

Palliative Care in Movement Disorders: Recommendations for Improvement

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Parkinsonism syndromes are associated with progressive disability and increased mortality, with symptom burden comparable to that of advanced cancer.

Parkinson Disease Symptom Fluctuations Well-Managed With Adaptive Deep Brain Stimulation

Parkinson Disease Symptom Fluctuations Well-Managed With Adaptive Deep Brain Stimulation

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Post-LFP change aDBS was deemed safe, tolerable, and effective among patients performing regular daily activities who were also taking additional dopaminergic drugs.

Cholinergic Activity Greater in <i>LRRK2</i> Mutation Carriers Regardless of Parkinson's Diagnosis

Cholinergic Activity Greater in LRRK2 Mutation Carriers Regardless of Parkinson's Diagnosis

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Significant between-group differences in acetylcholinesterase hydrolysis rates were observed among patients with LRRK2 PD, idiopathic PD, LRRK2 mutation carriers without PD, and healthy controls.

NDA for Inhaled Levodopa Therapy for Parkinson's Accepted by FDA

NDA for Inhaled Levodopa Therapy for Parkinson's Accepted by FDA

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The SPAN-PD trial found that Inbrija 84mg improved motor functions in Parkinson Disease experiencing off periods.

Resting Tremor Most Common in Early Parkinson Disease

Resting Tremor Most Common in Early Parkinson Disease

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Utilizing 123I-FP-CIT SPECT imaging of raphe serotonergic nuclei and putamen dopaminergic terminals may help detect factors that influence response to dopaminergic treatment.

Anesthesia in Parkinson Disease Requires Cautious Care

Anesthesia in Parkinson Disease Requires Cautious Care

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Anesthetic medications have been identified as a potential cause of morbidity in this population due to their interaction with the drugs used to manage Parkinson disease.

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

Specialized Physiotherapy for Parkinson's Reduces Costs, Disease-Related Complications

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The ParkinsonNet network was associated with reduced overall health care costs.

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

Serum Caffeine, Metabolites May Serve as Biomarkers for Parkinson Disease

The neuroprotective effect of caffeine has previously been examined in epidemiologic studies.

Levodopa Dose in Parkinson's Linked to Compulsive Sexual Behavior

Levodopa Dose in Parkinson's Linked to Compulsive Sexual Behavior

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The incidence of impulsive compulsive behaviors in patients with Parkinson's may be related to excessive stimulation of dopamine.

Anxiety May Help Predict Freezing of Gait in Parkinson Disease

Anxiety May Help Predict Freezing of Gait in Parkinson Disease

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The findings suggest that efforts to help prevent anxiety may help reduce risk for gait freezing.

Treadmill Exercise Safe for Patients With Parkinson Disease

Treadmill Exercise Safe for Patients With Parkinson Disease

High-intensity treadmill exercise appears to be a safe and tolerable option for physical activity in patients with Parkinson disease.

Little Evidence Supports CSF α-Synuclein as a Diagnostic Tool for Parkinson Disease

Little Evidence Supports CSF α-Synuclein as a Diagnostic Tool for Parkinson Disease

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The diagnosis of Parkinson disease is made mostly through a clinical assessment of motor signs and symptoms, which appear when approximately 70% of nigral neurons are lost.

Compulsive Behavior Disorders Common in Patients With Parkinson Disease With Dyskinesia

Compulsive Behavior Disorders Common in Patients With Parkinson Disease With Dyskinesia

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Patients with dyskinesia had a significantly higher frequency of impulse control disorders.

MRI in Parkinson Disease: Expanding Usability for Better Diagnostics

MRI in Parkinson Disease: Expanding Usability for Better Diagnostics

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MRI may be used to identify Parkinson disease biomarkers that can inform diagnosis, track disease progression, and elucidate the neurobiological underpinnings of symptoms.

Increased Mortality in Parkinson's Disease Linked to Low Antidepressant Adherence

Increased Mortality in Parkinson's Disease Linked to Low Antidepressant Adherence

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Given the prevalence of depression in Parkinson's disease and the effectiveness of antidepressants, health care providers should promote adherence in clinical practice.

Parkinson's, ALS Risk Increased in White-Collar Workers

Parkinson's, ALS Risk Increased in White-Collar Workers

There is a higher risk of death from Parkinson's disease or ALS in white collar workers.

Several Factors May Predict Cognitive Decline in Parkinson's Disease

Several Factors May Predict Cognitive Decline in Parkinson's Disease

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Dopamine deficiency, decreases in cortical thickness and volume in certain areas of the brain was predictive of cognitive decline.

Extended-Release Amantadine Reduces Levodopa-Induced Dyskinesia in Parkinson's Disease

Extended-Release Amantadine Reduces Levodopa-Induced Dyskinesia in Parkinson's Disease

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Patients in the treatment group had improved ON and OFF times and no worsening of motor function.

Risk for Death Significantly Increased in Patients With Synucleinopathies

Risk for Death Significantly Increased in Patients With Synucleinopathies

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Patients with multiple system atrophy with parkinsonism face the greatest risk for death among synucleinopathies.

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