Oral Contraceptives in Early Pregnancy Not Tied to Birth Defects

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Oral Contraceptives in Early Pregnancy Not Tied to Birth Defects
Oral Contraceptives in Early Pregnancy Not Tied to Birth Defects

HealthDay News — Exposure to oral contraception early on in pregnancy does not appear to increase the risk of birth defects, according to a study published in The BMJ. fdgasdfsd

Brittany Charlton, ScD, an instructor in the department of epidemiology at Harvard's T.H. Chan School of Public Health in Boston, and colleagues used national medical registries to collect data from Denmark from 1997 to 2011 on all live births, birth defects, and mothers' medical conditions. In all, 69% of mothers had used oral contraceptives, but stopped more than 3 months before pregnancy, and 21% had never used them. Eight percent of the women had stopped using oral contraceptives within 3 months of conception, and 1% used them after getting pregnant.

Among 880,694 births, 2.5% of the babies had a birth defect such as a cleft palate or an arm or leg defect, the researchers found. Specifically, Charlton's team found that for every 1,000 births, 25.1 infants of mothers who never used oral contraceptives had birth defects, as did 25.0 of infants of mothers who had used oral contraceptives more than 3 months before pregnancy. The rate was 24.9 among mothers who used oral contraceptives within 3 months of becoming pregnant, and 24.8 among mothers who used oral contraceptives before realizing they were pregnant.

"The prevalence of birth defects was consistent across each of the oral contraceptive groups as well as when we added in pregnancies that ended as stillbirths or induced abortions," Charlton told HealthDay. "Similarly, the results were also consistent even when we broke down the birth defects into different subgroups, like limb defects."

Reference

Charlton BM, Mølgaard-Nielsen D, Svanström H, Wohlfahrt J, Pasternak B, Melbye M, et al. Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study. BMJ. 2016; 352:h6712.

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